The interactive application and impacts of iron/nitrogen biogeochemical cycling in distributed ponds for non-point source pollution control in a watershed.

The linkages of distributed ponds are utilized in conjunction with one another to remediate non-point source (NPS) pollution in a water-scarce basin. This study provides an overview of a state-of-the-art thorough evaluation of ponds, which offers insight into the majority of topics covered by the ongoing scientific studies, including their various functions and factors affecting their functioning on the hydrological, physicochemical, and biological processes, such as environmental climate factors and basin-specific landscape configuration parameters, as well as process parameters for design, operation and management aspects. The linkages of ponds provide a variety of sustainable services (6R functions), such as resources, restoration, reduction, reuse, recycling, and recovery.

Associations of prognostic nutritional index with cardiovascular all-cause mortality among CVD patients with diabetes or prediabetes: evidence from the NHANES 2005-2018.

Background: Immunonutritional status is linked to the prognosis of cardiovascular disease (CVD) and diabetes, but the relationship between immunonutritional disorders and clinical outcomes in CVD patients with diabetes is unclear. This study aims to investigate the association of the novel immunonutritional indicator of prognostic nutritional index (PNI) with all-cause and CVD mortality in diabetic and prediabetic CVD patients.

Method: This is an open-cohort study involving 1,509 CVD patients with diabetes or prediabetes collected from The National Health and Nutrition Examination Survey (NHANES) and initially interviewed between 2005 and 2018.

Positive Lymph Node Status Before and After Neoadjuvant Chemoradiotherapy Improves Prediction of Disease-Free Survival in Esophageal Squamous Cell Carcinoma Patients.

Background: This study proposes a modified lymph node (LN) staging category (BALN) on the basis of the number of positive LNs before (prepN) and after (ypN) neoadjuvant chemoradiotherapy (nCRT) to improve prognostic stratification in esophageal squamous cell carcinoma (ESCC).

Patients And Methods: A total of 381 patients with ESCC who underwent nCRT at three medical centers were retrospectively enrolled. The ypN categories were scored according to the eighth edition of the American Joint Committee of Cancer (AJCC) staging manual.

The effect of zopiclone co-administration on sertraline initial dosage optimization in pediatric major depressive disorder patients based on model-informed precision dosing.

Objective: The present study aims to explore the initial dosage optimization of sertraline in pediatric major depressive disorder (MDD) patients based on model-informed precision dosing (MIPD).

Methods: A total of 111 pediatric MDD patients treated with sertraline were included for analysis using MIPD. Sertraline concentration levels, physiological and biochemical indexes of pediatric MDD patients, combined drug information were included in the construction of model.

Renal microangiopathy induced by lenvatinib in hepatocellular carcinoma: a case report and literature review.

Lenvatinib, a multi-target inhibitor of receptor tyrosine kinases, has been increasingly used in the treatment of advanced hepatocellular carcinoma (HCC). However, its association with renal adverse effects, including proteinuria and renal microvascular complications, was not fully understood in HCC patients. We reported a case of a 68-year-old male with a history of hypertension, diabetes mellitus, and hepatitis C virus (HCV) infection, diagnosed with primary HCC in 2015.

Arctic Tundra Plant Dieback Can Alter Surface NO Fluxes and Interact With Summer Warming to Increase Soil Nitrogen Retention.

In recent years, the arctic tundra has been subject to more frequent stochastic biotic or extreme weather events (causing plant dieback) and warmer summer air temperatures. However, the combined effects of these perturbations on the tundra ecosystem remain uninvestigated. We experimentally simulated plant dieback by cutting vegetation and increased summer air temperatures (ca.

Urolithin A Protects against Hypoxia-Induced Pulmonary Hypertension by Inhibiting Pulmonary Arterial Smooth Muscle Cell Pyroptosis via AMPK/NF-κB/NLRP3 Signaling.

Recent studies confirmed that pyroptosis is involved in the progression of pulmonary hypertension (PH), which could promote pulmonary artery remodeling. Urolithin A (UA), an intestinal flora metabolite of ellagitannins (ETs) and ellagic acid (EA), has been proven to possess inhibitory effects on pyroptosis under various pathological conditions. However, its role on PH remained undetermined.

Machine learning to predict lymph node metastasis in T1 esophageal squamous cell carcinoma: a multicenter study.

Background: Existing models do poorly when it comes to quantifying the risk of lymph node metastases (LNM). This study aimed to develop a machine-learning model for LNM in patients with T1 esophageal squamous cell carcinoma (ESCC).

Methods And Results: The study is multicenter and population based.

The gut microbiota-aromatic hydrocarbon receptor (AhR) axis mediates the anticolitic effect of polyphenol-rich extracts from .

Inflammatory bowel disease (IBD) is a significant global health concern. The gut microbiota plays an essential role in the onset and development of IBD. (SH), a traditional Chinese medicinal mushroom, has excellent anti-inflammatory effects and is effective at modulating the gut microbiota.

Changes in soil organic carbon components and microbial community following spent mushroom substrate application.

While spent mushroom substrate (SMS) has shown promise in increasing soil organic carbon (SOC) and improving soil quality, research on the interplay between SOC components and microbial community following the application of diverse SMS types remains scant. A laboratory soil incubation experiment was conducted with application of two types of SMSs from cultivation of (PE) and (AB), each at three application rates (3, 5.5, and 8%).

Overexpression of Improved Cadmium Accumulation and Tolerance in Tobacco ( L.).

Cadmium (Cd)-induced oxidative stress detrimentally affects hyperaccumulator growth, thereby diminishing the efficacy of phytoremediation technology aimed at Cd pollution abatement. In the domain of plant antioxidant mechanisms, the role of glutathione peroxidase (GPX) in conferring Cd tolerance to tobacco () remained unclear. Our investigation employed genome-wide analysis to identify 14 genes in tobacco, revealing their organization into seven subgroups characterized by analogous conserved domain patterns.

Covert Cerebrovascular Changes in People With Heart Disease: A Systematic Review and Meta-Analysis.

Background And Objectives: To determine the prevalence of silent brain infarction (SBI) and cerebral small vessel disease (CSVD) in adults with atrial fibrillation (AF), coronary artery disease, heart failure or cardiomyopathy, heart valve disease, and patent foramen ovale (PFO), with comparisons between those with and without recent stroke and an exploration of associations between heart disease and SBI/CSVD.

Methods: Medline, Embase, and Cochrane Library were systematically searched for hospital-based or community-based studies reporting SBI/CSVD in people with heart disease. Data were extracted from eligible studies.

Theoretical and experimental study of attenuation in cancellous bone.

Significance: Photoacoustic (PA) technology shows great potential for bone assessment. However, the PA signals in cancellous bone are complex due to its complex composition and porous structure, making such signals challenging to apply directly in bone analysis.

Aim: We introduce a photoacoustic differential attenuation spectrum (PA-DAS) method to separate the contribution of the acoustic propagation path to the PA signal from that of the source, and theoretically and experimentally investigate the propagation attenuation characteristics of cancellous bone.

-mediated melanin synthesis is essential to growth and development, stress adaption, and pathogenicity in .

Scytalone dehydratase (brm1) is one of the key enzymes in 1, 8-dihydroxynaphthalene (DHN) melanin synthesis, which mediates melanin biosythesis and regulates cell biological process of plant fungi, but its function in , the causal agent of pear black spot, is unclear. Brm1 in was cloned, identified, and named as . An -deletion mutant was generated and revealed that the deletion of leads to a significant decrease in melanin production and forms orange colony smooth spores.

Perinatal outcomes in patients undergoing repeat cerclage: A retrospective case series study.

Objective: This study aimed to describe the pregnancy outcomes of a case series of patients with probable cerclage failure who received repeat cerclage (RC) with potential indications.

Methods: We retrospectively collected a case series of 55 singleton pregnancies with RC from 2019 to 2022 in Shanghai, China. All included women provided written informed consent, and the study was approved by the ethics committees of the two hospitals.

Transvaginal cerclage for prevention of preterm birth in twin pregnancies with cervical dilatation or shortening: A prospective observational study.

Objective: To investigate the efficacy of transvaginal cerclage in twin pregnancies with cervical shortening, and to narrow the threshold cervical length for transvaginal cerclage.

Methods: This is a prospective cohort study and 177 twin pregnancies with asymptomatic cervical dilatation or cervical length of 15 mm or less between 16 and 25 weeks of pregnancy were included. Patients independently chose either transvaginal cerclage (n = 129) or no cerclage treatment (n = 48) after being consulted on the risk and potential benefit of transvaginal cerclage.

Strain-level screening of human gut microbes identifies as a new anti-hyperlipidemic probiotic.

Compelling evidence has tightly linked gut microbiota with host metabolism homeostasis and inspired novel therapeutic potentials against metabolic diseases (e.g., hyperlipidemia).

Responses of Trollius chinensis to drought stress and rehydration: From photosynthetic physiology to gene expression.

Drought stress occurs more frequently in recent years due to the global climate change. Widely distributed in northern China, Mongolia, and Russia, Trollius chinensis Bunge has high medicinal and ornamental values and is often exposed to drought stress, while the mechanism underlying its drought response is still unclear. In this study, we applied 74-76% (control, CK), 49-51% (mild drought), 34-36% (moderate drought), and 19-21% (severe drought, SD) of the soil gravimetric water content to T.

High-Dose Ionizing Radiation Accelerates Atherosclerotic Plaque Progression by Regulating P38/NCOA4-Mediated Ferritinophagy/Ferroptosis of Endothelial Cells.

Purpose: Radiation therapy (RT) significantly increased the incidence of coronary artery diseases, especially atherosclerosis. Endothelial dysfunction has been the major side effect of RT among tumor patients who received RT. However, the involvement between endothelial dysfunction and radiation-induced atherosclerosis (RIA) remains unclear.

HC-Net: A hybrid convolutional network for non-human primate brain extraction.

Brain extraction (skull stripping) is an essential step in the magnetic resonance imaging (MRI) analysis of brain sciences. However, most of the current brain extraction methods that achieve satisfactory results for human brains are often challenged by non-human primate brains. Due to the small sample characteristics and the nature of thick-slice scanning of macaque MRI data, traditional deep convolutional neural networks (DCNNs) are unable to obtain excellent results.

Remediation of lindane contaminated soil by fluidization-like dielectric barrier discharge.

This study proposed the fluidization-like dielectric barrier discharge (DBD) plasma for the remediation of lindane contaminated soil and integrated physical and chemical reaction pathway. Soil particle distribution within the reactor was simulated with Euler-Euler and Gidaspow drag models, and a bipolar pulsed power supply was applied to energize the DBD reactor after full fluidized. The effect of soil particles movement on electric features was discussed in terms of voltage waveforms and Lissajous figures.