Clinical significance and pro-oncogenic function of DBF4 in clear cell renal cell carcinoma.

Background: Clear cell renal cell carcinoma (ccRCC) is the most common malignant urological tumor, and regrettably, and is insensitive to chemotherapy and radiotherapy, resulting in poor patient outcomes. DBF4 plays a critical role in DNA replication and participates in various biological functions, making it an attractive target for cancer treatment. However, its significance in ccRCC has not yet been explored.

Preparation of red mud-modified sludge char through microwave-assisted one-step pyrolysis and steam activation and its adsorption properties for hydrogen sulfide.

To improve the hydrogen sulfide (HS) adsorption performance of sludge-derived char, a type of red mud-modified sludge char (RSC) was prepared through microwave-assisted one-step pyrolysis and steam activation of sludge and red mud (RM). The effects of pyrolysis temperature, RM mass percentage, and steam flow rate on the cumulative adsorption capacity of HS were systematically investigated using response surface method. The results indicated that the sludge char showed a significant increase in cumulative adsorption capacity from 1.

Optimization of nitrogen-doped sludge char preparation and mechanism study for catalytic oxidation of NO at room temperature.

Catalytic oxidation of NO at room temperature was carried out over nitrogen (N)-doped sludge char (SC) prepared from pyrolysis of municipal sewage sludge, and urea was adopted as nitrogen source. The effects of different N-doping methods (one-step and two-step method), dried sludge (DS)/urea mass ratios (5:1, 4:1, 3:1, 2:1, and 1:1), SC preparation procedures (pyrolysis only, pyrolysis with acid washing, and pyrolysis with KOH activation and acid washing), and different pyrolysis temperatures (500, 600, 700, and 800°C) on the catalytic oxidation of NO were compared to optimize the procedure for SC preparation. The results indicated that N-doping could obviously promote the catalytic performance of SC.

Electro-dewatering performance of sewage sludge under interrupted pulsating voltage: A comparison between square shape and half-sine shape waveform.

Electro-dewatering of sewage sludge with pulsating voltage was conducted under the two different wave shapes (square wave (SQW) and half-sine wave (HSW)) to investigate the influence of wave shape and duty cycle on sludge dewatering performance. The results indicated that, under the same average voltage, the moisture content of dewatered sludge with HSW was 10.3%-35.

[Applications of Artificial Intelligence in Pancreatic Cystic Lesion Imaging].

As the detection rate of pancreatic cystic lesions(PCL)increases,artificial intelligence(AI)has made breakthroughs in the imaging workflow of PCL,including image post-processing,lesion detection,segmentation,diagnosis and differential diagnosis.AI-based image post-processing can optimize the quality of medical images and AI-assisted models for lesion detection,segmentation,diagnosis and differential diagnosis significantly enhance the work efficiency of radiologists.This article reviews the application progress of AI in PCL imaging and provides prospects for future research directions.

Should All Pancreatic Cystic Lesions with Worrisome or High-Risk Features Be Resected? A Clinical and Radiological Machine Learning Model May Help to Answer.

Rationale And Objectives: According to current guidelines, pancreatic cystic lesions (PCLs) with worrisome or high-risk features may have overtreatment. The purpose of this study was to build a clinical and radiological based machine-learning (ML) model to identify malignant PCLs for surgery among preoperative PCLs with worrisome or high-risk features.

Materials And Methods: Clinical and radiological details of 317 pathologically confirmed PCLs with worrisome or high-risk features were retrospectively analyzed and applied to ML models including Support Vector Machine, Logistic Regression (LR), Decision Tree, Bernoulli NB, Gaussian NB, K Nearest Neighbors and Linear Discriminant Analysis.

Gypenoside XVII inhibits ox-LDL-induced macrophage inflammatory responses and promotes cholesterol efflux through activating the miR-182-5p/HDAC9 signaling pathway.

Ethnopharmacological Relevance: The deposition of lipids in macrophages and the subsequent formation of foam cells significantly increase the risk of developing atherosclerosis (As). Targeting ATP-binding cassette transporter A1/G1 (ABCA1/ABCG1)-mediated reverse cholesterol transport is crucial for regulating foam cell formation. Therefore, the search for natural chemical components with the ability to regulate ABCA1/G1 is a potential drug target to combat the development of atherosclerosis.

USP51 promotes non-small cell lung carcinoma cell stemness by deubiquitinating TWIST1.

Background: USP51 is a deubiquitinase (DUB), that is involved in diverse cellular processes. Accumulating evidence has demonstrated that USP51 contributes to cancer development. However, its impact on non-small cell lung carcinoma (NSCLC) cell malignancy is largely unknown.

Transformer guided progressive fusion network for 3D pancreas and pancreatic mass segmentation.

Pancreatic masses are diverse in type, often making their clinical management challenging. This study aims to address the task of various types of pancreatic mass segmentation and detection while accurately segmenting the pancreas. Although convolution operation performs well at extracting local details, it experiences difficulty capturing global representations.

A systematic review of prognosis predictive role of radiomics in pancreatic cancer: heterogeneity markers or statistical tricks?

Objectives: We aimed to systematically evaluate the prognostic prediction accuracy of radiomics features extracted from pre-treatment imaging in patients with pancreatic ductal adenocarcinoma (PDAC).

Methods: Radiomics literature on overall survival (OS) prediction of PDAC were all included in this systematic review. A further meta-analysis was performed on the effect size of first-order entropy.

Physicochemical Properties and Digestibility of Myofibrillar Proteins From the Scallop Mantle () Based on Ultrahigh Pressure Treatment.

The utilization of myofibrillar proteins (MPs) from the scallop mantle was limited due to its poor digestibility . In this study, structural properties and digestibility of MP were evaluated after modified by ultra-high pressure (UHP) at different pressures (0.1, 100, 200, 300, 400, and 500 MPa).

Farnesoid X Receptor Deficiency Induces Hepatic Lipid and Glucose Metabolism Disorder via Regulation of Pyruvate Dehydrogenase Kinase 4.

Farnesoid X receptors (FXR) are bile acid receptors that play roles in lipid, glucose, and energy homeostasis. Synthetic FXR-specific agonists have been developed for treating nonalcoholic fatty liver disease (NAFLD) patients. However, the detailed mechanism remains unclear.

Effect of ultrasonic treatment on the structure and functional properties of mantle proteins from scallops (Patinopecten yessoensis).

In this study, scallop mantle protein was treated by ultrasound at different powers, and then analyzed by ANS fluorescent probes, circular dichroism spectroscopy, endogenous fluorescence spectrum, DNTB colorimetry and in-vitro digestion model to elucidate the structure-function relationship. The results indicated that ultrasound can significantly affect the secondary structure of scallop mantle protein like enhancing hydrophobicity, lowering the particle size, increasing the relative contents of α-helix and decreasing contents of β-pleated sheet, β-turn and random coil, as well as altering intrinsic fluorescence intensity with blue shift of maximum fluorescence peak. But ultrasound had no effect on its primary structure.

Preparation of binder-less activated char briquettes from pyrolysis of sewage sludge for liquid-phase adsorption of methylene blue.

Binder-less activated char briquettes from sewage sludge were prepared and used for the liquid-phase adsorption of methylene blue. The properties of sludge char briquettes prepared under the different initial sludge moisture content, compression pressure, and heating rate were systematically investigated through the tests of thermogravimetric analysis (TGA), scanning electron microscopy (SEM), surface and mechanical properties, burn-off rates, methylene blue adsorption kinetics and isotherms. All of the prepared briquettes presented hierarchical structures and microporous/mesoporous characteristics, and the increase of initial sludge moisture content from 10 to 30 wt% resulted in a great increase of surface area (S), total pore volume (V), apparent density, and a slight decrease of mechanical performance.

CTRP1 decreases ABCA1 expression and promotes lipid accumulation through the miR-424-5p/FoxO1 pathway in THP-1 macrophage-derived foam cells.

Prevention of ATP binding cassette transporter A1 (ABCA1)-dependent cholesterol efflux leads to lipid accumulation in macrophages and atherosclerosis development. C1q tumor necrosis factor-related protein 1 (CTRP1), a conserved paralog of adiponectin, has been shown to aggravate atherosclerosis via its proinflammatory property. However, very little is known about its effects on ABCA1 expression and macrophage lipid accumulation.

Biochanin A Mitigates Atherosclerosis by Inhibiting Lipid Accumulation and Inflammatory Response.

Biochanin A (BCA), a dietary isoflavone extracted from red clover and cabbage, has been shown to antagonize hypertension and myocardial ischemia/reperfusion injury. However, very little is known about its role in atherogenesis. The aim of this study was to observe the effects of BCA on atherosclerosis and explore the underlying mechanisms.

Application of boundary electro-osmotic pulse to reduce sludge-to-wall adhesion.

Adhesion is one of the main features of sewage sludge. This paper aims at reducing sludge-to-wall adhesion through formation of a water layer induced by boundary electro-osmotic pulse (BEOP) which is characterized by distributing anodes and cathodes on one surface and exerting a pulsating current. The effects of the related parameters, including current intensity, exerting time, frequency, duty cycle (DTC), and the ratio of cathodic surface area to anodic surface area (C/A), on the adhesive stress of sewage sludge with different moisture content were thoroughly studied.

CTRP12 ameliorates atherosclerosis by promoting cholesterol efflux and inhibiting inflammatory response via the miR-155-5p/LXRα pathway.

C1q tumor necrosis factor-related protein 12 (CTRP12), a conserved paralog of adiponectin, is closely associated with cardiovascular disease. However, little is known about its role in atherogenesis. The aim of this study was to examine the influence of CTRP12 on atherosclerosis and explore the underlying mechanisms.

Experimental study on single-mode microwave-induced tungsten wire discharge for NO conversion in NO/N atmosphere.

Single-mode microwave-induced tungsten wire discharge was conducted to investigate discharge phenomena in Ar, N, NO, and their mixtures, as well as the effects of parameters, including diameter and number of tungsten wire, initial NO concentration, total gas flow rate, and microwave power, on NO conversion. The discharge phenomena verified that intense discharge could be observed in pure Ar or N, but the discharge was considerably weakened in gas mixtures. The results of NO conversion showed that the increases of the tungsten wire diameter (0.

Kidney xenotransplantation: Recent progress in preclinical research.

Kidney transplantation is the most effective treatment for end-stage renal disease, but is limited by the increasing shortage of deceased and living human donor kidneys. Xenotransplantation using pig organs provides the possibility to resolve the issue of organ supply shortage and is regarded as the next great medical revolution. In the past five years, there have been sequential advances toward the prolongation of life-supporting pig kidney xenograft survival in non-human primates, with the longest survival being 499 days.

LncRNA kcnq1ot1 promotes lipid accumulation and accelerates atherosclerosis via functioning as a ceRNA through the miR-452-3p/HDAC3/ABCA1 axis.

Kcnq1 overlapping transcript 1 (kcnq1ot1), an imprinted antisense lncRNA in the kcnq1 locus, acts as a potential contributor to cardiovascular disease, but its role in atherosclerosis remains unknown. The aim of this study was to explore the effects of kcnq1ot1 on atherogenesis and the underlying mechanism. Our results showed that kcnq1ot1 expression was significantly increased in mouse aorta with atherosclerosis and lipid-loaded macrophages.

The effectiveness of the combined problem-based learning (PBL) and case-based learning (CBL) teaching method in the clinical practical teaching of thyroid disease.

Background: This study aimed to evaluate the effectiveness and efficiency of PBL-CBL combined teaching in thyroid surgery and make observations from the students' perspectives, based on their satisfaction with the learning process.

Methods: We prospectively enrolled 354 fourth-year students majoring in clinical medicine, along with 232 residents, from September 2014 to June 2019. These participants were randomly allocated into either the combined PBL-CBL teaching group or the traditional lecture-based classroom group to attend a course about thyroid nodules.

Structural Insight into the Mechanism of 4-Aminoquinolines Selectivity for the alpha2A-Adrenoceptor.

Background: α-adrenoceptor (AR) is a potential target for the treatment of degenerative diseases of the central nervous system, and α-AR agonists are effective drugs for this condition. However, the lack of high selectivity for α-AR subtype of traditional drugs greatly limits their clinic usage.

Methods: A series of homobivalent 4-aminoquinolines conjugated by two 4-aminoquinoline moieties via varying alkane linker length (C2-C12) were characterized for their affinities for each α-AR subtype.

Syngas production from biomass pyrolysis in a continuous microwave assisted pyrolysis system.

In light of the knowledge gap in the scale-up of microwave-assisted pyrolysis technology, this study developed a continuous microwave-assisted pyrolysis (CMAP) system and examined its feasibility for syngas production. Wood pellets were pyrolyzed in the system under various temperatures, and the product distribution and energy efficiency were investigated. At a processing temperature of 800 °C, the CMAP system obtained a high quality producer gas (lower heating value 18.