Eur Child Adolesc Psychiatry
February 2025
Background: The role of functional connectivity (FC) changes in the prefrontal-thalamic-cerebellar circuit in schizophrenia has received widespread attention. Currently, domestic and international studies on this circuit have focused on adults, while the FC of this circuit in the brains of adolescent patients with schizophrenia (AOS) has been less reported.
Methods: We recruited 124 subjects who underwent resting-state functional magnetic resonance imaging scans at baseline, using key brain regions in the prefrontal-thalamic-cerebellar circuit as seed regions, to investigate the FC in AOS versus healthy controls.
Nanotechnology has ushered in significant advancements in drug design, revolutionizing the prevention, diagnosis, and treatment of various diseases. The strategic utilization of nanotechnology to enhance drug loading, delivery, and release has garnered increasing attention, leveraging the enhanced physical and chemical properties offered by these systems. Polyamidoamine (PAMAM) dendrimers have been pivotal in drug delivery, yet there is room for further enhancement.
View Article and Find Full Text PDFBackground & Aims: Gut microbiota is closely related to the occurrence and development of colorectal cancer (CRC). However, the differences in bacterial co-abundance groups (CAGs) between tumor tissue (TT) and normal tissue (NT), as well as their associations with clinical features, are needed to be clarified.
Methods: Bacterial 16 S rRNA sequencing was performed by using TT samples and NT samples of 251 patients with colorectal cancer.
Background: The striatum is thought to play a critical role in the pathophysiology and antipsychotic treatment of schizophrenia. Previous studies have revealed abnormal functional connectivity (FC) of the striatum in early-onset schizophrenia (EOS) patients. However, no prior studies have examined post-treatment changes of striatal FC in EOS patients.
View Article and Find Full Text PDFBackground: In patients with schizophrenia, there is abnormal regional functional synchrony. However, whether it also in patients with adolescent-onset schizophrenia (AOS) remains unclear. The goal of this study was to analyze the regional homogeneity (ReHo) of resting functional magnetic resonance imaging to explore the functional abnormalities of the brain in patients with AOS.
View Article and Find Full Text PDFBackground: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and is prevalent in East Asia. Although genome-wide association studies (GWASs) of HCC have identified 23 risk regions, the susceptibility genes underlying these associations largely remain unclear. To identify novel candidate genes for HCC, we conducted liver single-tissue and cross-tissue transcriptome-wide association studies (TWASs) in two populations of East Asia.
View Article and Find Full Text PDFThis study investigated how different feedback sources, such as teacher and peer correction, affect students learning English as a foreign language (EFL) regarding speaking accuracy, fluency, and academic passion. The effects of online and face-to-face instruction and peer and teacher corrections were investigated in this study using a factorial design. Convenience sampling was used to choose six intact classes from Jinzhong University's Department of Foreign Languages.
View Article and Find Full Text PDFA liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the analysis of ribavirin in chicken. Samples was extracted with 0.1% formic acid and purified by Hypercarb cartridge prior to LC-MS/MS analysis.
View Article and Find Full Text PDFFacing a stressful environment of peer rejection and discrimination, Chinese migrant adolescents are at high risk of developing behavior problems while receiving insufficient family support. In this context, the current study aimed to explore the pathway from peer rejection to adolescent behavior problems via the mediating role of delinquent peer affiliation and with the moderating roles of parental company and parental monitoring taken into consideration. A sample of 2041 migrant adolescents (46.
View Article and Find Full Text PDFThe taste of tea is one of the key indicators in the evaluation of its quality and is a key factor in its grading and market pricing. To objectively and digitally evaluate the taste quality of tea leaves, miniature near-infrared (NIR) spectroscopy and electronic tongue (ET) sensors are considered effective sensor signals for the characterization of the taste quality of tea leaves. This study used micro-NIR spectroscopy and ET sensors in combination with data fusion strategies and chemometric tools for the taste quality assessment and prediction of multiple grades of black tea.
View Article and Find Full Text PDFVibrio parahaemolyticus, is one of the most frequently reported pathogenic microorganisms that causes foodborne illnesses worldwide. The aims of the current study were to determine the prevalence, virulence genes, antimicrobial resistance, biofilm formation ability (BFA) and genetic characterization of V. parahaemolyticus recovered from retail aquatic products in Nanjing, China.
View Article and Find Full Text PDFInt J Environ Res Public Health
September 2022
Based on the social and psychological capital framework, this study aimed to investigate the direct effect of bullying on adolescents' subjective well-being and to reveal the potential psychosocial mechanisms in this relationship. Through the multi-stage cluster random sampling procedure, a cross-sectional survey was conducted among 728 adolescents from Hebei Province in China. Structural equation modeling was adopted for data analysis.
View Article and Find Full Text PDFObjective: Knowledge, belief, and behavior model (knowledge-attitude-practice (KAP)) is known as a cognitive model. Health education is important to the prognosis of patients, including chronic obstructive pulmonary disease (COPD) patients. However, the investigation regarding health education based on the KAP model is few.
View Article and Find Full Text PDFThe object of this study is to examine the effects of a short-term intensive-type Cognitive Behavioral Therapy (CBT) intervention to prevent internet addiction among Chinese college students. We conducted a randomized controlled trial applying a group counseling intervention program based on CBT. Data included 21 participants in the intervention group and 22 participants in the control group.
View Article and Find Full Text PDFBackground: Compared to adult-onset schizophrenia, relatively few neuroimaging studies have examined functional connectivity (FC) abnormalities in adolescent-onset schizophrenia (AOS). The present study was designed to investigate resting-state interhemispheric connectivity patterns among drug-naive first-episode AOS patients and potential changes following short-term antipsychotic drug treatment.
Methods: This study included 107 drug-naïve, first-episode AOS patients (age: 15.
Multiplexing the ion packet injection with advanced signal processing is an effective method to improve both the ion throughput and signal-to-noise ratio for ion mobility spectrometry. Generally used multiplexing methods include Hadamard transform ion mobility spectrometry (HT-IMS), Fourier transform ion mobility spectrometry (FT-IMS), and correlation ion mobility spectrometry (C-IMS). However, HT-IMS sometimes suffer from false peaks and further processing is needed, FT-IMS generally requires longer spectra acquisition time than the traditional signal averaging method, and C-IMS also demonstrated drawbacks such as spectra baseline distortions when using traditional on-off binary gating switches.
View Article and Find Full Text PDFAtten Percept Psychophys
February 2022
Attention is influenced by information about relationships between ourselves and the objects around us. Self-related objects can either facilitate or disrupt task performance, creating a challenge for identifying the precise nature of the influence of self-relatedness on attention. To address this challenge, we measured different components of attention (alertness and orienting) in the presence of self-related objects using a revised attention network task (ANT).
View Article and Find Full Text PDFOverexpression of reactive oxygen species in the substantia nigra pars compacta destroys dopaminergic neurons and accelerates the pathological process of Parkinson's disease (PD). In this study, a new hydrophilic nano-bioconjugate, lactoferrin (Lf)-modified Au-Bi Se nanodot (ND) for efficient PD therapy is developed. In particular, the Lf-Au-Bi Se NDs exhibit strong blood-brain barrier (BBB) permeation.
View Article and Find Full Text PDFThe association between perfectionism and addictive behaviors has been examined in previous literature; however, few pieces of research have investigated the mediating and moderating mechanisms underlying this relationship. Using a sample of 2016 Chinese college students, the present study examined the mediator of depression between maladaptive perfectionism and Internet addiction and the moderator of gender in such associations. The findings indicated that maladaptive perfectionism was directly related to students' Internet addiction and indirectly predicted students' Internet addiction via the mediator of depression.
View Article and Find Full Text PDFObjective: This study was aimed to establish a quantitative detection method for meat contamination based on specific polypeptides.
Methods: Thermally stable peptides with good responses were screened by high resolution liquid chromatography tandem mass spectrometry. Standard curves of specific polypeptide were established by triple quadrupole mass spectrometry.
Micropapillary features are seen in pure mucinous carcinoma of breast (PMC), which is termed mucinous carcinoma with micropapillary features (MPMC). However, whether MPMC can be identified as a morphologically, clinically or genetically distinct entity from PMC remains controversial. In this study, a retrospective review of 161 cases of breast mucinous carcinoma was conducted to assess the clinicopathologic features, prognostic implications, and genomic alterations of MPMC and PMC.
View Article and Find Full Text PDFGenetic diversity in plants is remarkably high. Recent whole genome sequencing (WGS) of 67 rice accessions recovered 10,872 novel genes. Comparison of the genetic architecture among divergent populations or between crops and wild relatives is essential for obtaining functional components determining crucial traits.
View Article and Find Full Text PDFThe development of the central nervous system (CNS) is a complex process that must be exquisitely controlled at multiple levels to ensure the production of appropriate types and quantity of neurons. RNA alternative polyadenylation (APA) contributes to transcriptome diversity and gene regulation, and has recently been shown to be widespread in the CNS. However, the previous studies have been primarily focused on the tissue specificity of APA and developmental APA change of whole model organisms; a systematic survey of APA usage is lacking during CNS development.
View Article and Find Full Text PDFGuang Pu Xue Yu Guang Pu Fen Xi
November 2016
The conventional qualitative analysis of near infrared spectroscopy (NIR) commonly uses one single classification model. This paper focused on the fusion of multiple classifiers based on different single classifiers by using the fused classifier to determine different varieties of red-wines. NIR spectra of 170 red-wine samples were collected by using Fourier transform near-infrared spectrometer.
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