Publications by authors named "Wenya Ren"
Article Synopsis
- Chronic hepatitis B virus (HBV) infection remains a major health concern, especially regarding the timing of antiviral therapy.
- This study analyzed liver histological changes in 339 treatment-naïve patients with normal alanine aminotransferase (ALT) levels, focusing on differences between HBeAg-positive and HBeAg-negative individuals.
- Key findings showed that HBsAg and AST levels were critical for assessing liver inflammation, while HBV DNA load and age were important for evaluating liver fibrosis in patients with normal ALT levels.
Background: Psoas abscess (PA) is an uncommon disease that has been increasingly reported in the recent years. We reviewed patients with PA and analyzed their clinical characteristics to improve our understanding of this rare disorder.
Methods: We retrospectively reviewed the clinical presentations, microbiology, and outcomes of patients with PA between 2011 and 2022 at the Zhejiang Provincial People's Hospital in China.
Article Synopsis
- Autoimmune hepatitis (AIH) is a common liver disease, but there are no effective noninvasive tests for assessing liver fibrosis in these patients, prompting the need for a new predictive model.
- The study analyzed data from 374 AIH patients and developed a prediction model using logistic regression, which was validated on additional patient data to ensure its reliability.
- Key factors like age, platelet count, and A/G ratio were found to be significant indicators of liver fibrosis, and the new model outperformed existing methods (APRI and FIB-4) in accuracy.
Article Synopsis
- Hepatitis E virus infection is primarily known for causing liver-related symptoms but can also lead to serious conditions like immune-mediated thrombotic thrombocytopenic purpura (TTP), as illustrated in a unique case study.
- A 53-year-old male patient presented with fever, low platelet count (thrombocytopenia), and liver dysfunction, ultimately diagnosed with acute hepatitis E, which triggered TTP.
- Following specific treatments, including plasmapheresis and glucocorticoids, the patient showed significant improvement, highlighting the importance of screening for hepatitis E in patients with liver issues and low platelet counts.
Article Synopsis
- This study focuses on developing a predictive model using serum biomarkers for the early diagnosis of hepatorenal syndrome in patients with chronic hepatitis B cirrhosis.
- It involved analyzing data from 255 patients, using logistic regression to identify key risk factors—hemoglobin, total bilirubin, and creatinine—associated with the condition.
- The model showed strong predictive accuracy, with ROC curve values of 0.968 and 0.980 in training and validation groups, respectively, confirming the biomarkers’ effectiveness as early indicators of the syndrome.