Publications by authors named "Wenya Liu"

Sepsis remains a life-threatening condition with high mortality rates despite current therapeutic approaches. While Huang-Lian-Jie-Du Decoction (HLJDD), a traditional Chinese medicine formula, has been historically used to treat inflammatory conditions, its therapeutic potential in sepsis and underlying mechanisms remain unexplored. This study investigated HLJDD's comprehensive effects on sepsis pathophysiology using a rat cecal ligation and puncture (CLP) model.

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Microcystin-LR (MC-LR), the most prevalent and diverse cyanotoxin produced by harmful cyanobacterial blooms, has been linked to gastrointestinal toxicity. Therefore, we conducted a case-control study across four regions in China to investigate this relationship. Inflammatory bowel disease (IBD) cases (219) were matched with healthy controls (438) based on age and gender and conditional logistic regression models and Restricted cubic splines were used to evaluate the association between MC-LR exposure and IBD risk.

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  • Cucurbitacin B (CuB) is a natural compound known for its strong anticancer effects, but its effectiveness is limited due to poor absorption in the body when taken orally.
  • Researchers studied how CuB is metabolized in rats after oral administration, identifying 13 metabolites, with one key variant, CuB-Cys, showing similar anti-cancer activity as CuB but with less toxicity toward normal cells.
  • The study sheds light on CuB's metabolic pathways and suggests that using its metabolites, like CuB-Cys, could enhance its therapeutic effects while minimizing side effects in cancer treatment.
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  • - The study aimed to assess how the contrast-enhancement-boost (CE-boost) technique affects image quality in obese patients during computed tomography pulmonary angiography (CTPA) compared to two other methods: hybrid iterative reconstruction (HIR) and model-based iterative reconstruction (MBIR).
  • - Conducted on 100 patients, the results indicated that CE-boost significantly improved visibility and CT values over HIR and MBIR in both obese and non-obese patients, with MBIR showing the least image noise.
  • - Ultimately, CE-boost outperformed HIR regarding diagnostic confidence and vascular contrast, suggesting it is particularly effective for enhancing pulmonary artery imaging in obese individuals.
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  • L-DOPA is the main treatment for Parkinson's Disease but can cause involuntary movements known as Levodopa-induced dyskinesia (LID) over time.
  • The study reveals that the protein serum response factor (SRF) activates the FosB gene, leading to increased dyskinetic movements in a mouse model of Parkinson's treated with L-DOPA.
  • Knocking down SRF reduced involuntary movements, while overexpressing it worsened LID; additionally, the Akt signaling pathway was found to play a significant regulatory role in this process.
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  • - The study aims to create a standardized MRI classification for brucellosis spondylitis (BS) to improve treatment methods and post-treatment follow-up.
  • - It analyzed data from 615 patients diagnosed with BS over 12 years, identifying key MRI characteristics and categorizing them into three main types, with Type II being the most common.
  • - The findings suggest that using MRI features can enhance the diagnosis and treatment strategies for BS, providing a framework for ongoing patient management.
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Epidemiological studies on associations of organophosphate ester (OPE) exposure and gestational diabetes mellitus (GDM) risk, which remain rare and inconclusive, were carried out with a case-control population comprising 287 GDM and 313 non-GDM pregnant women recruited from Tianjin. The GDM group suffered distinctly higher serum concentrations of tri--butyl phosphate (TNBP), tri(2-butoxyethyl) phosphate (TBOEP), triphenyl phosphate (TPHP), tri-iso-propyl phosphate (TIPP), and tri(1-chloro-2-propyl) phosphate (TCIPP) than the healthy control group ( < 0.001).

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Based on the previously developed Al/CuNCs probe, the matrix effect (ME) derived from protein was investigated in the fluorescence determination of fluoroquinolones (FQs) residues in eggs, and a sample pretreatment method was established to rapidly reduce the ME. Molecular docking results indicated that the three main egg proteins and FQs were bound by hydrogen bond, van der Waals force, and alkyl groups, leading to the loss of FQs response signal, and then produced ME. After trichloroacetic acid treatment, the mean particle size of egg matrix decreased, the protein secondary structure changed, and the crystal structure was destroyed.

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Ischemic stroke is the most important cause of disability and death worldwide, but current treatments remain limited. Traditional Chinese medicine (TCM) including the herb pair of Zhiqiao-Danggui (ZD) offers a multifaceted treatment approach through promoting blood circulation, yet its specific anti-ischemic mechanism remains unclear. This study used the photochemically induced thrombosis (PIT) mouse model and the oxygen glucose deprivation/reoxygenation (OGD/R) cell model to explore the therapeutic effect of ZD on ischemic stroke.

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Objectives: To investigate the value of intralesional and perilesional radiomics based on computed tomography (CT) in predicting the bioactivity of hepatic alveolar echinococcosis (HAE).

Materials And Methods: In this retrospective study, 131 patients who underwent surgical resection and diagnosed HAE in pathology were included (bioactive, n=69; bioinactive, n=62). All patients were randomly assigned to the training cohort (n=78) and validation cohort (n=53) in a 6:4 ratio.

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Background: Fluoroquinolones (FQs) are widely used in livestock and poultry industry because of their satisfactory effects in preventing and treating bacterial infection. However, due to irrational use and poor biodegradability, FQs can easily remain in food animals and further enter the human body through the food chain. Therefore, accurate and sensitive detection of FQs residues in animal-origin food is significant.

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In this study, the β-cyclodextrin encapsulated betanin (BET@β-CD) with improved thermal stability and retention as well as the berberine (BBR) with aggregate induced luminescence effect were incorporated into corn amylose (CA) biomatrix to develop colorimetric/fluorescent dual-channel smart film. Results shown that the added functional components were uniformly distributed in the film matrix. The high tensile strength (78.

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Objectives: Magnetic resonance (MR)-based radiomics features of brain metastases are utilised to predict epidermal growth factor receptor (EGFR) mutation and human epidermal growth factor receptor 2 (HER2) overexpression in adenocarcinoma, with the aim to identify the most predictive MR sequence.

Methods: A retrospective inclusion of 268 individuals with brain metastases from adenocarcinoma across two institutions was conducted. Utilising T1-weighted imaging (T1 contrast-enhanced [T1-CE]) and T2 fluid-attenuated inversion recovery (T2-FLAIR) sequences, 1,409 radiomics features were extracted.

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Objective: This study aimed to investigate the magnetic resonance imaging (MRI) features and classification of echinococcosis of the spinal canal.

Methods: The clinical manifestations and MRI findings and classification of 19 patients diagnosed with intraspinal echinococcosis over 10 years (2011-2020) were retrospectively analyzed.

Results: The mean age of the nine males and 10 females was 39 years (range 28-65 years).

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In this study, the polyvinylpyrrolidone-alizarin nanoparticles (PVP-AZ NPs) with favorable water dispersion and the carbon quantum dots (RQDs) with aggregate induced emission effect were synthesized to construct an eco-friendly film for food freshness monitoring. The introduction of PVP-AZ NPs and RQDs enhanced the network structure and thermal stability of the cassava starch/polyvinyl alcohol film, and reduced its crystallinity and light transmittance via non-covalent binding with the film-forming matrix. The developed film exhibited visually recognizable colorimetric and fluorescent responses to ammonia at 0.

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Radiation-induced skin damage (RID) is the most prevalent, significant side effect of radiotherapy (RT). Nearly 95% of patients experience moderate to severe skin reactions after receiving radiation therapy. However, criteria for acute radiation dermatitis (ARD) treatment remain unavailable.

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In this study, based on aggregation-induced emission (AIE) effect and antenna effect, a novel portable fluorescent responsive membrane was constructed with red carbon dots (R-CDs) as reference signal and terbium coordination polymer (Tb-AMP CPs) as response signal for visual, instrument-free, and sensitive detection of fluoroquinolones (FQs). Specifically, the fluorescent responsive membrane (R-T membrane) was prepared by physically depositing R-CDs with AIE property and Tb-AMP CPs on the surface of polyvinylidene fluoride filter membranes at ambient temperature. In the presence of FQs, Tb in the Tb-AMP CPs of the prepared membrane coordinated with the β-diketone structure of FQs, which turned on the yellow-green fluorescence through the "antenna effect".

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The pericarp of (HPP) has traditionally been used for treating jaundice and hepatitis. However, the specific hepatoprotective components and their safety/efficacy profiles remain unclear. This study aimed to characterize the total cucurbitacins (TCs) extracted from HPP and evaluate their hepatoprotective potential.

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Herein, a novel dual-mode probe for organophosphorus pesticides (OPs) colorimetric and photothermal detection was developed based on manganese modified porphyrin metal-organic framework (PCN-224-Mn). PCN-224-Mn had excellent oxidase-like activity and oxidized colorless 3,3,5,5-tetramethylbenzidine (TMB) to blue-green oxidation state TMB (oxTMB), which exhibited high temperature under near-infrared irradiation. l-ascorbate-2-phosphate was hydrolyzed by acid phosphatase to produce ascorbic acid, which weakened colorimetric and photothermal signals by impacting oxTMB generation.

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  • 4-octyl itaconate (4-OI) is a derivative known for its anti-inflammatory and antioxidant properties, and this study explores its potential to protect the liver from oxidative stress-related injuries.
  • The research demonstrated that 4-OI reduced cytotoxicity and oxidative stress in liver cells and activated key signaling pathways (PI3K/AKT/mTOR and MAPK) that play a role in its protective effects.
  • In mouse models, 4-OI decreased liver damage from acetaminophen and increased the expression of protective proteins, indicating that its antioxidant effects are linked to the activation of the Nrf2/Sirt3 pathway through phosphorylation of AKT and ERK1/2.
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Background: Trigonella foenum-graecum L. is a Leguminosae plant, and the stems, leaves, and seeds of this plant are rich in chemical components that are of high research value. The chloroplast (cp) genome of T.

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Rationale And Objectives: The aim of this study was to explore the potential of a newly developed dark-blood imaging technique to improve image quality and plaque visibility in head and neck computed tomography (CT) angiography.

Materials And Methods: Patients who underwent triphasic head and neck CT angiography scans from August 2021 to March 2023 were retrospectively enrolled (mean age 67.23 ± 10.

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Trichlorfon, one of the most widely used organophosphate insecticides, is commonly employed in aquaculture and agriculture to combat parasitic infestations. However, its inherent instability leads to rapid decomposition into dichlorvos (DDVP), increasing its toxicity by eightfold. Therefore, the environmental effects of trichlorfon in real-world scenarios involve the combined effects of trichlorfon and its degradation product, DDVP.

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  • * The structures of the new compounds were determined using detailed spectroscopic analysis and TD-DFT-based ECD calculations.
  • * In vitro testing revealed that several isolated compounds exhibited significant anti-inflammatory activity, particularly one compound that demonstrated the strongest effect with an IC value of 426.2 nM against nitric oxide production in activated microglia cells.
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In this work, a bimetallic organic framework (Cu/UiO-66) based "turn on" fluorescent aptamer probe was designed for the high-efficiency detection of zearalenone (ZEN). In the probe, the 6-carboxyfluorescein-labeled aptamer (FAM-Apt) was used as the recognition element, and the electrostatic interaction, coordination effect, and photoinduced electron transfer effect between FAM-Apt and Cu/UiO-66 caused fluorescence quenching. When ZEN existed, FAM-Apt recognized ZEN specifically, causing FAM-Apt to separate from the surface of Cu/UiO-66 and recovery of fluorescence.

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