Publications by authors named "Wenxuan Xu"

Human activities have led to an increase in atmospheric carbon dioxide (CO) concentration, which can enhance the flux of CO from air to water, thus impacting algal growth. Phosphorus (P) is a key factor influencing the formation of cyanobacteria blooms. Nutrient utilization is closely related to carbon (C) metabolism, but the effects of elevated CO on microalgae under different P sources are rarely studied.

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The study of gain clamping in broadband bismuth-doped fiber amplifiers (BDFA) not only helps to solve the gain instability problem due to the variation of the number of optical multiplexing channels but also is an effective way to extend the amplifier's operating bandwidth to improve the communication capacity. In this paper, we illustrate the advantages of linear cavity gain clamping through simulation. Using simulation to guide the experiments, we propose a BDFA with tunable linear-cavity gain clamping and incorporate a variable optical attenuator (VOA) in the linear cavity to enhance the flexibility of gain control.

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Determining the extent of tunnel loosening zones is a crucial factor in establishing reasonable support parameters. Addressing the challenge of testing tunnel loosening zones, this study focused on the Dongmachang Tunnel No. 1.

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Article Synopsis
  • Researchers have developed glucose-responsive insulin release systems, using chitosan-based three-compartment microspheres (TCMs) to achieve prolonged insulin delivery.
  • The TCMs release insulin based on blood glucose levels, as glucose generates gluconic acid, which degrades chitosan and triggers insulin release from compartments with varying concentrations.
  • In tests, TCMs showed longer-lasting insulin release and effective blood glucose regulation in diabetic cell models, demonstrating promising potential for diabetes treatment and insulin research.
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Diabetic macular edema (DME) is a common complication of diabetes that can lead to vision loss, and anti-vascular endothelial growth factor (anti-VEGF) therapy is the standard of care for DME, but the treatment outcomes vary widely among patients. This study collected optical coherence tomography (OCT) images and clinical data from DME patients who received anti-VEGF treatment to develop and validate deep learning (DL) models for predicting the anti-VEGF outcomes in DME patients based on convolutional neural network (CNN) and multilayer perceptron (MLP) combined architecture by using multimodal data. An Xception-MLP architecture was utilized to predict best-corrected visual acuity (BCVA), central subfield thickness (CST), cube volume (CV), and cube average thickness (CAT).

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A feeding study lasting 30 days was carried out to determine the effects of dietary Oryzanol (Ory) on the survival, growth, antioxidant capacity, peptic enzymes, as well as lipid metabolism of larvae (11.87 ± 0.59 mg) using four different Ory concentrations in microfeed formulations (0, 20, 40, and 80 mg/kg), all preserving isolipidic (18.

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Article Synopsis
  • * Self-healing nanofibrous materials are lightweight and breathable but face stability challenges due to strong fiber interactions.
  • * A new strategy to stabilize these materials has led to the creation of a flexible, ultrathin self-healing electrode that can monitor signals continuously without harming skin or plant health.
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Article Synopsis
  • Recent advancements in breast cancer treatment have improved survivorship, leading to increased focus on functionality and aesthetics, yet breast cancer-related lymphedema (BCRL) remains a major issue.
  • The Lymphatic Microsurgical Preventive Healing Approach (LYMPHA) is a common method for preventing BCRL, but challenges arise due to deep surgical sites and potential complications from high venous pressures and prior radiotherapy.
  • A modified technique called distally based LYMPHA (dLYMPHA) was developed, showing promising results in a study where BCRL rates were significantly lower in patients who underwent this approach compared to those who did not.
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Lysosomes regulate cellular metabolism to maintain cell survival, but the mechanisms whereby they determine neuronal cell fate after acute metabolic stress are unknown. Neuron-enriched lysosomal membrane protein LAMP2A is involved in selective chaperone-mediated autophagy and exosome loading. This study demonstrates that abnormalities in the neuronal LAMP2A-lysosomal pathway cause neurological deficits following ischemic stroke and that this is an early inducer of the PANoptosis-like molecular pathway and neuroinflammation, simultaneously inducing upregulation of FADD, RIPK3, and MLKL after ischemia.

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Nickel-based metal-organic frameworks (MOFs) with flexible structure units provide a broad platform for designing highly efficient electrocatalysts, especially for alkaline oxygen evolution reaction (OER). However, the stability of MOFs under harsh and dynamic reaction conditions poses significant challenges, resulting in ambiguous structure-activity relationships in MOFs-based OER research. Herein, Ni-benzenedicarboxylic acid-based MOF (NiBDC) is selected as prototypical catalyst to elucidate  its real active sites for OER and reaction pathway under different reaction states.

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Hematogenous metastasis involves cancer cell migration to different locations from the primary tumor through the blood circulation. Von Willebrand factor (VWF) has been shown to play an important role in tumor cell adhesion to and extravasation from the endothelial cell lining of blood vessel walls during cancer metastasis. VWF may contribute to this process by interacting with tumor cells, endothelial cells, and platelets through various cell membrane receptors, such as platelet glycoprotein (GP)Ibα, P-selectin, αβ and αβ integrins, and glycocalyx.

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Phytoplankton growth in freshwater is often limited by the availability of phosphorus (P), and thorough understandings of P availability are essential to prevent algal blooms. However, the differences in bioavailability and utilization mechanisms of different P forms remain unclear, especially whether organophosphorus could be used as P sources. This study investigated the effects of 0.

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Chinese medicine is a unique and complex medical system with complete and rich scientific theories. The textual data of Traditional Chinese Medicine (TCM) contains a large amount of relevant knowledge in the field of TCM, which can serve as guidance for accurate disease diagnosis as well as efficient disease prevention and treatment. Existing TCM texts are disorganized and lack a uniform standard.

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Finding suitable fiber amplifiers is one of the key strategies to increase the transmission capacity of fiber links. Recently, bismuth-doped fiber amplifiers (BDFAs) have attracted much attention due to their distinctive ultra-wideband luminescence properties. In this paper, we propose a linear cavity double pass structure for BDFA operating in the O and E bands.

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Article Synopsis
  • Tin phosphide (SnP) is a promising anode material for sodium-ion batteries due to its high theoretical capacity.
  • The study introduces Co-doped SnP, specifically SnCoP/C, which is embedded in carbon-based materials and shows better performance in sodium-ion batteries compared to traditional SnP/C.
  • Cobalt doping enhances the stability and diffusion of sodium in the electrode material, significantly improving its electrochemical properties, such as cycle stability and reversible capacity.
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RNA polymerases must transit through protein roadblocks to produce full-length transcripts. Here we report real-time measurements of Escherichia coli RNA polymerase passing through different barriers. As intuitively expected, assisting forces facilitated, and opposing forces hindered, RNA polymerase passage through lac repressor protein bound to natural binding sites.

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Objective: Multi-modal magnetic resonance (MR) image segmentation is an important task in disease diagnosis and treatment, but it is usually difficult to obtain multiple modalities for a single patient in clinical applications. To address these issues, a cross-modal consistency framework is proposed for a single-modal MR image segmentation.

Methods: To enable single-modal MR image segmentation in the inference stage, a weighted cross-entropy loss and a pixel-level feature consistency loss are proposed to train the target network with the guidance of the teacher network and the auxiliary network.

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Recently, the demand for healthcare products especially wearable smart masks is increasing. The biosafety and degradability of smart masks are crucial for human health and environmental protection. However, the development of biodegradable and biocompatible fibrous membranes with high filtration efficiency and low pressure drop is still a challenge.

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The sol-gel method is used to synthesize a new compound called NaFeV(PO)/C (NFVP/C), which has a crystal structure and belongs to the NASICON-type family. The dimensions of NFVP's unit cell are = 8.717 (1) Å, = 21.

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Border fences have severely impeded the transboundary migration of a number of large mammals worldwide, with central Asia being one of the most impacted. The Marco Polo sheep (Ovis ammon polii), an iconic species of Pamir, is threatened in its transboundary movement by increasing border fencing among their five distributed countries, including Tajikistan, Kyrgyzstan, China, Afghanistan, and Pakistan. In this study, by building ensemble species distribution models, we found that eastern Tajikistan had the largest suitable Macro Polo sheep habitat (about 42 % of the total suitable habitat), followed by China (about 32 %).

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Objective: Intestinal flora homeostasis in rats with type 2 diabetes mellitus (T2DM) was evaluated to explore the effects of total saponins (TAS) on hepatic insulin resistance (IR).

Methods: Six-week-old male Sprague-Dawley rats were fed high-fat and high-sugar diet for 4 weeks and intraperitoneally injected with streptozotocin to induce T2DM, and they were then randomly divided into control, model, metformin, and TAS groups. Stool, serum, colon, and liver samples were collected after 8 weeks of drug administration for relevant analyses.

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Purpose: To evaluate the potential relationships between serum interleukin (IL)-2, IL-4, IL-6, IL-10, IL-17, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α levels and occurrence of respiratory failure in patients with early-stage COVID-19 disease.

Patients And Methods: We analyzed clinical characteristics, laboratory parameters, and immunoinflammatory markers in 302 patients diagnosed with SARS-CoV-2 infection who required hospitalization at Changshu Hospital of Nantong University. IL-2, IL-4, IL-6, IL-10, IL-17, IFN-γ, and TNF-α levels in the peripheral blood of patients hospitalized five days after disease onset were measured using multiplex bead-based flow fluorescent immunoassay (MBFFI).

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Bacteria-based tumor therapy has attracted much attention due to its unique mechanism and abundant application. With the rapid development of synthetic biology, utilizing gene technology to make bacteria express therapeutic agents has greatly innovated bacterial therapy paradigms. Herein, we constructed an expressing promelittin protein system based on the Trojan horse strategy, which limited the toxicity of melittin through the fusion protein during melittin expression.

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Acute kidney injury (AKI) is closely associated with the overproduction of reactive oxygen species (ROS), which can cause multiple organ dysfunctions without timely treatment. However, only supportive treatments are currently available for AKI in clinics. Here, we developed nanomaterials of hyperbranched polyphosphoester (PPE) containing abundant thioether (S-PPE NP) and thioketal bonds (TK-PPE NP).

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