Determination of Methamphetamine by High-Performance Liquid Chromatography in Odor-Adsorbent Material Used for Training Drug-Detection Animals.

The objective of the present report was to develop and validate a simple, sensitive, and selective analytical method for the determination of methamphetamine in an odor-adsorbent material (gauze) which was used to improve and standardize the training method used for drug-detection animals. High-performance liquid chromatography (HPLC) was performed using a Spherisorb ODS2 C18 column (200 mm × 4.6 mm, 5 μm), with a mobile phase consisting of a 0.

Sodium propionate improves cognitive and memory function in mouse models of Alzheimer's disease.

This study was designed to explore whether sodium propionate (SP) alleviates cognitive damage in a mouse model of Alzheimer's disease (AD). We evaluated behavioral and biochemical aspects in an animal model of AD made by intracerebroventricular injection of Aβ peptide. Two-month-old ICR mice were treated with SP or normal saline for 21 days (control group, Aβ group, Aβ + SP50 mg/kg group, Aβ + SP100 mg/kg group, and Aβ + SP200 mg/kg group).

Verification of a multi-function closed maze for the detection of affective disorder and spatial cognitive impairment in post-weaning socially isolated rats.

Objective: To verify a behavioral device for the detection of learning, memory, and affective disorders in post-weaning socially isolated rats.

Methods: We tested the behavioral changes in post-weaning socially isolated rats using a multi-function closed maze, a self-developed behavioral device, against the classical mood disorder detection method, the IntelliCage system and Morris water maze.

Results: In the multifunctional closed maze experiment, the spatial learning and memory ability of post-weaning socially isolated rats decreased, which was consistent with the results of the water maze and IntelliCage system.