Immunoregulatory programs in anti-N-methyl-D-aspartate receptor encephalitis identified by single-cell multi-omics analysis.

Background: Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) is a prevalent type of autoimmune encephalitis caused by antibodies targeting the NMDAR's GluN1 subunit. While significant progress has been made in elucidating the pathophysiology of autoimmune diseases, the immunological mechanisms underlying anti-NMDARE remain elusive. This study aimed to characterize immune cell interactions and dysregulation in anti-NMDARE by leveraging single-cell multi-omics sequencing technologies.

Alternative splicing perspective to prey preference of environmentally friendly biological agent Cryptolaemus montrouzieri.

Background: Cryptolaemus montrouzieri (Coccinellidae) is widely utilized as biological control agents in modern agriculture. A comprehensive understanding of its food preference can help guide mass rearing and safety management during field application of pest control. Although some studies have paid attentions to the impacts of prey shift on C.

Unravelling chilling-stress resistance mechanisms in endangered Mangrove plant Lumnitzera littorea (Jack) Voigt.

Lumnitzera littorea (Jack) Voigt is one of the most endangered mangrove species in China. Previous studies have showed the impact of chilling stress on L. littorea and the repsonses at physiological and biochemical levels, but few attentions have been paid at molecular level.

Molecular Dissection Unveiling Dwarfing Effects of Plant Growth Retardants on Pomegranate.

Dwarfed stature is a desired trait for modern orchard production systems. One effective strategy for dwarfing cultivation is exogenously applying plant growth retardants (PGRs) to plants. However, for many economic fruit trees, the current knowledge on the regulatory mechanisms underlying the dwarfing effect of PGRs is limited, which largely restricts the agricultural application of PGRs.

Optical OAM tweezer based on graded-index multimode fibers.

A fiber-optic probe consisting of a section of graded-index multimode fiber (GIMF) fused onto a few-mode fiber (FMF) is proposed in this paper. The orbital angular momentum (OAM) mode guided by the FMF was launched into the GIMF, and a focused OAM beam profile was obtained by tailoring the length of the GIMF. Based on the analysis of the propagation trajectory, the intensity distributions, and the phase distributions of the vortex beam in GIMF, the focusing properties of the OAM mode were investigated.