Mesenchymal stem cell-derived small extracellular vesicles restored nasal barrier function in allergic rhinitis via miR-143-GSK3B in human nasal epithelial cells.

Background: The nasal epithelial barrier is the first line of defense against the deep entry of pathogens or aeroallergens and is more critical in allergic rhinitis (AR). Restoring epithelial barrier dysfunction might be a promising strategy for AR. Recent studies reported that mesenchymal stem cell-derived small extracellular vesicles (MSC-sEV) potentially inhibit the inflammation response and promote tissue regeneration.

Three-stages tectonic evolution controls the differential distribution of hydrocarbons in the West Java backarc basin.

The West Java Basin is a typical back-arc basin in Southeast Asia and one of Indonesia's main petroleum provinces. In the past ten years, it has been found that the new hydrocarbon reserves are on the rise, and a amount of resources to be discovered is significant. The distribution of hydrocarbon resources and the tectonic evolution characteristics of the basin are systematically explored, and the differences in hydrocarbon distribution and its main controlling factors in the back-arc basin of West Java are analyzed.

Platycodon D reduces obesity and non-alcoholic fatty liver disease induced by a high-fat diet through inhibiting intestinal fat absorption.

Background: Platycodin D (PD) has been reported to treat metabolic diseases, including non-alcoholic fatty liver disease. In addition, platycodin D has been reported to activate intestinal 5'AMP-activated protein kinase (AMPK) phosphorylation levels, thereby reducing lipid absorption. Therefore, the aim of this study is to explore whether PD activation of intestinal AMPK and reduced lipid absorption can improve non-alcoholic fatty liver disease.