Iterative-Weighted Thresholding Method for Group-Sparsity-Constrained Optimization With Applications.

Taking advantage of the natural grouping structure inside data, group sparse optimization can effectively improve the efficiency and stability of high-dimensional data analysis, and it has wide applications in a variety of fields such as machine learning, signal processing, and bioinformatics. Although there has been a lot of progress, it is still a challenge to construct a group sparse-inducing function with good properties and to identify significant groups. This article aims to address the group-sparsity-constrained minimization problem.

Important role of Bacillus subtilis as a probiotic and vaccine carrier in animal health maintenance.

Bacillus subtilis is a widespread Gram-positive facultative aerobic bacterium that is recognized as generally safe. It has shown significant application value and great development potential in the animal farming industry. As a probiotic, it is frequently used as a feed growth supplement to effectively replace antibiotics due to its favourable effects on regulating the intestinal flora, improving intestinal immunity, inhibiting harmful microorganisms, and secreting bioactive substances.

Optimization and evaluation of resveratrol amorphous solid dispersions with a novel polymeric system.

The preparation of amorphous solid dispersions using polymers is a commonly used formulation strategy for enhancing the solubility of poorly water-soluble drugs. However, a single polymer often does not bring significantly enhance the solubility or amorphous stability of a poorly water-soluble drug. We found an application of a unique and novel binary polymeric blend in the preparation of solid dispersions.

Discriminability of single-trial EEG during decision-making of cooperation or aggression: a study based on machine learning.

Decision-making is a very important cognitive process in our daily life. There has been increasing interest in the discriminability of single-trial electroencephalogram (EEG) during decision-making. In this study, we designed a machine learning based framework to explore the discriminability of single-trial EEG corresponding to different decisions.

Pan-Genomic and Transcriptomic Analyses of Marine Hao 2018 Revealed Its Genomic and Metabolic Features.

The genomic and carbohydrate metabolic features of Hao 2018 ( Hao 2018) were investigated through pan-genomic and transcriptomic analyses, and key enzyme genes that may encode the process involved in its extracellular polysaccharide synthesis were screened. The pan-genome of the strains consists of a core-genome containing 2331 genes, an accessory-genome containing 956 genes, and a unique-genome containing 1519 genes. Clusters of Orthologous Groups analyses showed that harbors strain-specifically diverse metabolisms, probably representing high evolutionary genome changes.

Effect of Different Initial Fermentation pH on Exopolysaccharides Produced by Hao 2018 and Identification of Key Genes Involved in Exopolysaccharide Synthesis via Transcriptome Analysis.

Exopolysaccharides (EPSs) are carbohydrate polymers produced and secreted by microorganisms. In a changing marine environment, EPS secretion can reduce damage from external environmental disturbances to microorganisms. Meanwhile, EPSs have promising application prospects in the fields of food, cosmetics, and pharmaceuticals.

Iterative Weighted Group Thresholding Method for Group Sparse Recovery.

This article proposes a novel iterative weighted group thresholding method for group sparse recovery of signals from underdetermined linear systems. Based on an equivalent weighted group minimization problem with l -norm ( ), we derive closed-form solutions for a subproblem with respect to some specific values of p when using the proximal gradient method. Then, we design the corresponding algorithmic framework, including stopping criterion and the method of nonmonotone line search, and prove that the solution sequence generated by the proposed algorithm converges under some mild conditions.

Optimizing Movement for Maximizing Lifetime of Mobile Sensors for Covering Targets on a Line.

Given a set of sensors distributed on the plane and a set of Point of Interests (POIs) on a line segment, a primary task of the mobile wireless sensor network is to schedule covering the POIs by the sensors, such that each POI is monitored by at least one sensor. For balancing the energy consumption, we study the min-max line barrier target coverage (LBTC) problem which aims to minimize the maximum movement of the sensors from their original positions to their final positions at which the coverage is composed. We first proved that when the radius of the sensors are non-uniform integers, even 1-dimensional LBTC (1D-LBTC), a special case of LBTC in which the sensors are distributed on the line segment instead of the plane, is NP -hard.

Isolation, Characterization, and Pharmaceutical Applications of an Exopolysaccharide from .

Many marine bacteria secrete exopolysaccharides (EPSs), which are made up of a substantial component of the macro-molecules surrounding cells. Recently, the wide demand for EPSs for food, cosmetics, pharmaceutical and other applications has led to great interest in them. In this study, an EPS produced by marine bacteria HZ strains (EPS-A) was isolated and purified to examine its structure and biological function.

Enhanced anti-proliferative efficacy of epothilone B loaded with Escherichia coli Nissle 1917 bacterial ghosts on the HeLa cells by mitochondrial pathway of apoptosis.

Epothilones constitute a new class of microtubule-stabilizing anti-cancer agents with promising preclinical and clinical activity. However, its systemic application still causes some toxic side effects. To reduce these undesired effects, advanced drug delivery systems based on cell targeting carriers are needed currently.

Homotopy Methods Based on $l_{0}$ -Norm for Compressed Sensing.

This paper proposes two homotopy methods for solving the compressed sensing (CS) problem, which combine the homotopy technique with the iterative hard thresholding (IHT) method. The homotopy methods overcome the difficulty of the IHT method on the choice of the regularization parameter value, by tracing solutions of the regularized problem along a homotopy path. We prove that any accumulation point of the sequences generated by the proposed homotopy methods is a feasible solution of the problem.

Efficient production of safety-enhanced Escherichia coli ghosts by tandem expression of PhiX 174 mutant gene E and staphylococcal nuclease A gene.

The application of bacterial ghosts as vaccines is limited because of their low lysis efficiency and production and the presence of pathogenic islands and/or antibiotic resistance genes within ghost preparations. To overcome these problems, a new lysis plasmid with fusion gene of mutant gene E and staphylococcal nuclease A gene (mE-L-SNA) were constructed and characterized. The new plasmid pBV-mELS could efficiently induce the genetic inactivation of Escherichia coli cultures, accompanied by the intracellular degradation of the genetic material of host cells, devoid of the presence of pathogenic islands and antibiotic resistance genes within ghost preparations.

Anti-atherosclerotic activity of platycodin D derived from roots of Platycodon grandiflorum in human endothelial cells.

This study examined the effects of platycodin D (PD), a triterpene saponin from the the root of Platycodon grandiflorum A.DC on human umbilical vein endothelial cells (HUVECs) in vitro, which were pre-treated with PD (0.01, 0.

Generation of biotechnology-derived Flavobacterium columnare ghosts by PhiX174 gene E-mediated inactivation and the potential as vaccine candidates against infection in grass carp.

Flavobacterium columnare is a bacterial pathogen causing high mortality rates for many freshwater fish species. Fish vaccination with a safe and effective vaccine is a potential approach for prevention and control of fish disease. Here, in order to produce bacterial ghost vaccine, a specific Flavobacterium lysis plasmid pBV-E-cat was constructed by cloning PhiX174 lysis gene E and the cat gene with the promoter of F.

Comparative study of c-Fos expression in rat dorsal vagal complex and nucleus ambiguus induced by different durations of restraint water-immersion stress.

Restraint water-immersion stress (RWIS) of rats induces vagally-mediated gastric dysfunction. The present work explored the effects of different durations of RWIS on neuronal activities of the dorsal vagal complex (DVC) and the nucleus ambiguous (NA) in rats. Male Wistar rats were exposed to RWIS for 0, 30, 60, 120, or 180 min.

c-Fos expression in the supraoptic nucleus is the most intense during different durations of restraint water-immersion stress in the rat.

Restraint water-immersion stress (RWIS) can induce anxiety, hypothermia, and severe vagally-mediated gastric dysfunction. The present work explored the effects of different durations of RWIS on neuronal activities of the forebrain by c-Fos expression in conscious rats exposed to RWIS for 0, 30, 60, 120, or 180 min. The peak of c-Fos induction was distinct for different forebrain regions.