Systematic review and meta-analyses: What has the application of Mendelian randomization told us about the causal effect of adiposity on health outcomes?

Mendelian randomization (MR) is increasingly used for generating estimates of the causal impact of exposures on outcomes. Evidence suggests a causal role of excess adipose tissue (adiposity) on many health outcomes. However, this body of work has not been systematically appraised.

A new strategy for RRS-based determination of phosphate with a bifunctional FeO magnetic nanoparticle surface molecularly imprinted polydopamine probe.

In this paper, a magnetic nanoparticle surface molecularly imprinted polydopamine RRS probe FeO@MIP was prepared using phosphomolybdic acid (PMo) as the template, FeO magnetic nanoparticles as the substrate and dopamine hydrochloride (PD) as the monomer and crosslinking agent for the determination of PO. Under acidic conditions, phosphomolybdic acid is formed by the reaction of PO with ammonium molybdate (MSA), which can be imprinted with the FeO@MIP probe surface and reduced to phosphomolybdic blue (PMoB) by ascorbic acid (Aa). Strong resonance Rayleigh scattering energy transfer (RRS-ET) occurs between the probe and PMoB, resulting in a decrease in the RRS signal value.

Occupational Benzene Exposure and Lung Cancer Risk: A Pooled Analysis of 14 Case-Control Studies.

Benzene has been classified as carcinogenic to humans, but there is limited evidence linking benzene exposure to lung cancer. We aimed to examine the relationship between occupational benzene exposure and lung cancer. Subjects from 14 case-control studies across Europe and Canada were pooled.

Automated Coding of Job Descriptions From a General Population Study: Overview of Existing Tools, Their Application and Comparison.

Objectives: Automatic job coding tools were developed to reduce the laborious task of manually assigning job codes based on free-text job descriptions in census and survey data sources, including large occupational health studies. The objective of this study is to provide a case study of comparative performance of job coding and JEM (Job-Exposure Matrix)-assigned exposures agreement using existing coding tools.

Methods: We compared three automatic job coding tools [AUTONOC, CASCOT (Computer-Assisted Structured Coding Tool), and LabourR], which were selected based on availability, coding of English free-text into coding systems closely related to the 1988 version of the International Standard Classification of Occupations (ISCO-88), and capability to perform batch coding.

Mechanism-based structure-activity relationship (SAR) analysis of aromatic amines and nitroaromatics carcinogenicity via statistical analyses based on CPDB.

Cancer is a leading cause of human mortality around the globe. In this study, mechanism-based SAR (Structure-Activity Relationship) was employed to investigate the carcinogenicity of aromatic amines and nitroaromatics based on CPDB. Principal component analysis and cluster analysis were used to construct the SAR model.