Publications by authors named "Wenxin Lu"

Utilizing solar energy to extract and purify potable water from atmospheric humidity offers a viable approach to combat water scarcity in diverse geographical areas. However, current technologies face challenges related to low efficiency due to the low intrinsic permeability and weak hydrophilicity of HO, followed by ineffectiveness in diverse climatic conditions and long-lasting implementation. Herein, we develop a highly hygroscopic photothermal hydrogels consisting of chitosan polypyrrole (CP) copolymer matrix and zinc ions (Zn).

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Repairing critical bone defects remains a formidable challenge in regenerative medicine. Scaffolds that can fill defects and facilitate bone regeneration have garnered considerable attention. However, scaffolds struggle to provide an ideal microenvironment for cell growth and differentiation at the interior of the bone defect sites.

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Effectively regulating the rotary motions of molecular rotors through external stimuli poses a tremendous challenge. Herein, a new type of molecular rotor based on azobenzene-strapped mixed (phthalocyaninato)(porphyrinato) rare earth triple-decker complex is reported. Electronic absorption and H NMR spectra manifested the reversible isomerization of the rotor between the configuration and the configuration.

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Immune-mediated bone regeneration driven by bone biomaterials offers a therapeutic strategy for repairing bone defects. Among 2D nanomaterials, TiCT MXenes have garnered substantial attention for their potential in tissue regeneration. This investigation concentrates on the role of MXene nanocomposites in modulating the immune microenvironment within bone defects to facilitate bone tissue restoration.

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Background: To date, a growing body of evidence suggests that unfolded protein response (UPR) sensors play a vital role in carcinogenesis. However, it remains unclear whether they are involved in pancreatic ductal adenocarcinoma (PDAC) and how they relate to clinical outcomes. This study aims to investigate the biological function and mechanism of how a novel UPR sensor, CREB3L1 works in PDAC and further evaluate its clinical application prospect.

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We proposed a viewing angle controller (VAC) for car co-driver displays (CDDs). This VAC, integrated with the co-driver display, provides necessary information to the co-driver while minimizing driver distraction. It comprises two parallel alignment liquid crystal cells and two negative C films.

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The parametric g-formula is a causal inference method that appropriately adjusts for time-varying confounding affected by prior exposure. Like all parametric methods, it assumes correct model specification, usually assessed by comparing the observed outcome with the simulated outcome under no intervention (natural course). However, it is unclear how to evaluate natural course performance and whether other variables should also be considered.

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Retrosynthesis, the strategy of devising laboratory pathways by working backwards from the target compound, is crucial yet challenging. Enhancing retrosynthetic efficiency requires overcoming the vast complexity of chemical space, the limited known interconversions between molecules, and the challenges posed by limited experimental datasets. This study introduces generative machine learning methods for retrosynthetic planning.

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Background: Doxorubicin (DOX) is a potent anticancer medication, but its significant cardiotoxicity poses a challenge in clinical practice. Galangin (Gal), a flavonoid compound with diverse pharmacological activities, has shown potential in exerting cardioprotective effects. However, the related molecular mechanism has not been fully elucidated.

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Introduction: Effective risk communication is essential for achieving patient-centered oral health care, but the limited understanding of patients' subjective perceptions of orthodontic-related risks hinders this process. This study aimed to investigate adults' awareness, concerns, and risk-avoidance behaviors about long-term orthodontic risks, exploring their relationship with psychosocial factors.

Methods: We included 498 adult patients (mean age, 27.

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Article Synopsis
  • Breast cancer significantly impacts women's health, with 70% of cases being estrogen receptor positive, and cancer stem cells contributing to tumor relapse and spread.
  • RUNX3, a tumor suppressor often deactivated in these cancers, was studied to understand its role in regulating cancer stem cell traits.
  • The research revealed that RUNX3 suppresses the expression of EXOSC4 by binding to its promoter, and lower EXOSC4 levels correlate with improved survival in patients with Luminal B/Her2 breast cancer, showcasing RUNX3's tumor-suppressive effects.
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Article Synopsis
  • The study evaluated the effectiveness of near-infrared imaging (NIRI) and unaided visual examination (UVE) in detecting proximal caries in comparison to cone-beam computed tomography (CBCT) as the standard reference.
  • The results showed that NIRI had high agreement rates with CBCT, particularly in detecting initial caries and significantly improved detection rates when combined with UVE, especially for moderate-to-advanced caries.
  • The findings suggest that while NIRI cannot fully replace traditional imaging methods, it offers a promising radiation-free option for early detection of caries, highlighting its potential role in routine dental assessments.
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Objective: To construct a prognostic model based on MR features and clinical data to evaluate the progression free survival (PFS), overall survival (OS) and objective response rate (ORR) of pancreatic cancer patients with hepatic metastases who received chemoimmunotherapy.

Methods: 105 pancreatic cancer patients with hepatic metastases who received chemoimmunotherapy were assigned to the training set (n = 52), validation set (n = 22), and testing set (n = 31). Multi-lesion volume of interest were delineated, multi-sequence radiomics features were extracted, and the radiomics models for predicting PFS, OS and ORR were constructed, respectively.

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Background: Cooking-related biomass smoke is a major source of household air pollution (HAP) and an important health hazard. Prior studies identified associations between HAP exposure and childhood stunting; less is known for underweight and wasting. Few studies had personal HAP measurements.

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Research on the interaction between nanoscale materials and light holds significant scientific significance for the development of fields such as optoelectronic conversion and biosensing. The study of micro- and nano-optics has produced numerous outstanding research achievements by utilizing the dielectric optical coupling mechanism and plasmon effects to enhance the interaction between light and matter. These findings have demonstrated tremendous potential for applications in the field of molecular fingerprint sensing.

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Background: Frailty is an important geriatric syndrome predicting adverse health outcomes in older adults. However, the longitudinal characteristics of frailty components in post-hip fracture patients are less understood. Adopting the Fried frailty definition, we examined the longitudinal trends and sex trajectory differences in frailty and its components over 1 year post-fracture.

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The accumulation of nano metal oxide particles (NMOPs) in municipal sewage treatment systems harms the microbial community and its metabolism in activated sludge system, resulting in the degradation of its pollutants removal performance. In this work, the stress effect of NMOPs on the denitrifying phosphorus removal system was systematically investigated in terms of pollutants removal performance, key enzyme activities, microbial community diversity and abundances, and intracellular metabolites. Among the ZnO NPs, TiO NPs, CeO NPs, and CuO NPs, the ZnO NPs showed the most significant impacts with the chemical oxygen demand, total phosphorus, and nitrate nitrogen removal ratio decreased from above 90 % to 66.

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Introduction: Clear aligners (CAs) have attracted increasing attention from patients and orthodontists because of their excellent esthetics and comfort. However, treating tooth extraction patients with CAs is difficult because their biomechanical effects are more complicated than those of traditional appliances. This study aimed to analyze the biomechanical effect of CAs in extraction space closure under different anchorage controls, including moderate, direct strong, and indirect strong anchorage.

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Women and children in rural regions of low-income countries are exposed to high levels of household air pollution (HAP) as they traditionally tend to household chores such as cooking with biomass fuels. Early life exposure to air pollution is associated with aeroallergen sensitization and developing allergic diseases at older ages. This prospective cohort study assigned HAP-reducing chimney stoves to 557 households in rural Guatemala at different ages of the study children.

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The development of novel wound dressings with highly effective antibacterial and accelerating wound healing properties has become the focus of current research. In this study, a novel and injectable lactoferrin (LF)/lithium magnesium silicate hydrogel (LMSH) was first synthesized through a simple electrostatic interaction method. The physical and biological properties are systematically characterized.

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One of the most straightforward approaches to access chiral silanes is catalytic enantioselective hydrosilylation. Although significant advances have been achieved in enantioselective construction of either a carbon-stereogenic center or a silicon-stereogenic center through enantioselective hydrosilylation, simultaneous establishment of a carbon- and a silicon-stereogenic center in an acyclic molecule through a single intermolecular hydrosilylation remained undeveloped. Herein, an unprecedented cobalt-catalyzed regio-, diastereo- and enantioselective hydrosilylation of 1,3-dienes is presented, enabling construction of a carbon- and a silicon-stereogenic center in a single intermolecular transformation.

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Uncontrolled growth of lithium dendrite is the key challenge that impedes the practical application of Li anodes in high-energy-density Li-metal batteries. Precisely constructing lithiophilic active sites on the anode surface is expected to be an effective strategy for promoting the anode interfacial properties and alleviating the dendrite growth of lithium. Herein, a diyne-linked phthalocyanine polymer (PcEP) with precise lithiophilic active sites is designed and constructed in a bottom-up manner on the surface of the copper foil the coupling reaction of tetraethynylphthalocyanine.

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Catalytic sequential hydrosilylation of 1,3-enynes and 1,4-enynes promoted by cobalt complexes derived from bisphosphines are presented. Site- and stereoselective Si-H addition of primary silanes to 1,3-enynes followed by sequential intramolecular diastereo- and enantioselective Si-H addition afforded enantioenriched cyclic alkenylsilanes with simultaneous construction of a carbon-stereogenic center and a silicon-stereogenic center. Reactions of 1,4-enynes proceeded through sequential isomerization of the alkene moiety followed by site- and stereoselective hydrosilylation.

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