RGS6 Drives Spinal Cord Injury by Inhibiting AMPK Pathway in Mice.

Objective: Oxidative stress and inflammation play critical roles in the pathogenesis of spinal cord injury (SCI). Regulator of G protein signaling 6 (RGS6) is involved in controlling ROS generation and inflammatory response under different contexts. This study is aimed at investigating its role and underlying mechanism in SCI.

Psychological impact on COVID-19 patients during the outbreak in China: A case-control study.

Background: The coronavirus disease 2019 (COVID-19) has caused widespread panic due to its highly infectious and pandemic transmission. We aimed to evaluate the psychological impact of the COVID-19 outbreak on infected subjects in China.

Methods: This case-control, survey-based study assessed the psychological status of COVID-19 patients and non-infected controls from February 10 to March 18, 2020, in China.

MicroRNA-328-3p facilitates the progression of gastric cancer via KEAP1/NRF2 axis.

Gastric cancer is a common lethal malignancy and causes great cancer-related mortality worldwide. MicroRNA (miR)-328-3p is implicated in the progression of various human cancers; however, its role and mechanism in the progression of gastric cancer remain unclear.Human gastric cancer cells were incubated with miR-328-3p mimic, inhibitor or the matched negative control.

Clinical characteristics and endovascular treatment in patients with intracranial giant serpentine aneurysms.

Background: Giant serpentine aneurysms (GSAs) are a rare subtype of intracranial aneurysm. Recently, GSAs have been successfully treated with endovascular parent artery occlusion with or without distal bypass. The present study retrospectively analyzed the clinical outcomes of endovascular parent artery occlusion for intracranial GSAs.