Hydrogen sulfide (HS) plays crucial inflammatory modulating roles, representing a promising candidate for anti-inflammatory therapies. However, current HS delivery approaches lack sufficient specificity against inflammatory response. Herein, regarding the overexpressed aminopeptidase N (APN) at the inflammation sites, an APN-activated self-immolative carbonyl sulfide (COS)/HS donor (AlaCOS) was developed for inflammatory response-specific HS delivery.
View Article and Find Full Text PDFBackground: Sustained attention deficits were reported more significant in patients with major depressive disorder (MDD) than in healthy controls (HCs), and are pivotal in both the development and aggravation of depression. Childhood trauma is also common in MDD and the exposure to childhood trauma may impede sustained attention and increase the treatment resistance in MDD. However, the underlying neuro-mechanisms link the childhood trauma to sustained attention deficits in MDD remain unclear.
View Article and Find Full Text PDFBiomed Pharmacother
December 2024
Liver fibrosis is a progressive condition characterized by excessive deposition of extracellular matrix components, leading to organ dysfunction. Chronic inflammation and activation of hepatic stellate cells (HSCs) are two dominant events in all stages of fibrosis development. The receptor for advanced glycation end products (RAGE) pathway is involved in modulating liver injury and fibrosis, and preventing it, or deletion of Ager gene can protect the liver against fibrosis progression.
View Article and Find Full Text PDFBehav Brain Res
February 2025
Background And Purpose: Diffusion tensor imaging along perivascular spaces (DTI-ALPS) is an index that may provide insights into intracranial waste clearance processes. Glymphatic system dysfunction has been suggested to play a role in the development of major depressive disorder (MDD). Additionally, fatigue-a common precursor of MDD-is also closely connected to the waste clearance function of the central nervous system (CNS), further underscoring the significance of efficient waste removal in MDD.
View Article and Find Full Text PDFBackground: Few studies have explored the associated factors of attitudes of nonpsychiatric nurses towards mental disorders. Therefore, this study is aimed to evaluate the attitudes of nonpsychiatric nurses towards mental disorders and especially explore the association between psychiatric clinical practice and these attitudes.
Methods: A total of 1324 nonpsychiatric nurses and students majoring in nursing were recruited through an online questionnaire from December 2021 to March 2022 in Sichuan Province, China.
Overcoming the intrinsic low activity of most peroxidase mimics under neutral pH is crucial but still extremely challenging for the detection of disease markers in biological samples. Here, we chose nanoclay (i.e.
View Article and Find Full Text PDFLocal geometric configurations of metal cations in inorganic enzyme mimics determine their catalytic behaviors, while their optimization remains challenging. Herein, kaolinite, a naturally layered clay mineral, achieves the optimization of cationic geometric configuration in manganese ferrite. We demonstrate that the exfoliated kaolinite induces the formation of defective manganese ferrite and makes more iron cations fill into the octahedral sites, significantly enhancing the multiple enzyme-mimicking activities.
View Article and Find Full Text PDFControllable preparation is the current frontier in the field of inorganic nanomaterial-based artificial enzymes (nanozymes). For ferrites, the factors affecting cation occupancy are very complex, making the modulation of cation occupancy extremely challenging. Herein, we report a new strategy to modulate the cation occupancy of manganese ferrite (MFO) based on the structural properties of nanoclay (i.
View Article and Find Full Text PDFA novel surface acidity modulation strategy allows us to obtain modified nanoclay with specific peroxidase (POD)-like catalytic activity. Fe exchange could increase the surface acidity of modified montmorillonite (MMT), resulting in a significant enhancement of its POD-like activity. We proposed that the POD-like catalytic reaction followed the electron transfer pathway and ping-pong mechanism.
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