Publications by authors named "Wenxian Qian"
Background: Understanding the status and function of tumor-infiltrating immune cells is essential for improving immunotherapeutic effects and predicting the clinical response in human patients with carcinoma. However, little is known about tumor-infiltrating immune cells, and the corresponding research results in hepatocellular carcinoma (HCC) are limited.
Aim: To investigate potential biomarker genes that are important for the development of HCC and to understand how immune cell subsets react throughout this process.
Human adenovirus is an infectious agent that causes respiratory infections in adults and children. It has been found that immunocompromised children are highly susceptible to this pathogen, as it can swiftly evolve into severe pneumonia with multiple sequelae. Due to the lack of immunity in children, the body's response mechanisms to innate and acquired immunity are specialized.
View Article and Find Full Text PDFPorcine circovirus-associated diseases, caused by porcine circovirus type 2 (PCV2), are widespread and result in significant economic losses to the global swine industry. PCV2 can currently be divided into nine genotypes (PCV2a to PCV2i), with the currently dominant one being the PCV2d genotype. In this study, 2675 samples from 804 pig farms in 13 cities in Jiangsu Province, China, were collected between 2014 and 2021 and subjected to polymerase chain reaction analysis to investigate the frequency and genetic diversity of PCV2.
View Article and Find Full Text PDFBackground: Severe adenovirus pneumonia in children has a high mortality rate, but research on risk prediction models is lacking. Such models are essential as they allow individualized predictions and assess whether children will likely progress to severe disease.
Methods: A retrospective analysis was performed on children with adenovirus pneumonia who were hospitalized at the Children's Hospital of Nanjing Medical University from January 2017 to March 2024.
miR-214-3p promotes the pathogenesis of Parkinson's disease by inhibiting autophagy.
Biomed Pharmacother
February 2024
Article Synopsis
- Parkinson's disease (PD) is a common neurodegenerative disorder caused by the loss of dopamine-producing neurons, resulting in motor issues and linked to autophagy dysfunction.
- This study investigates the role of miR-214-3p in PD, finding that it hinders autophagy and leads to the death of dopaminergic neurons, worsening PD symptoms when overexpressed.
- The research also uncovers that miR-214-3p targets ATG3, highlighting its potential as a biomarker and therapeutic target to improve autophagy and protect neurons in PD.