Atractylodin: An Alkyne Compound with Anticancer Potential.

Atractylodin is one of the main active ingredients of . It has various pharmacological properties, such as antigastric ulcer, immune regulation, antibacterial, anti-inflammatory, antitumor, anti-oxidant, and neuroprotective properties. In the past few decades, atractylodin has attracted the attention of researchers due to its excellent therapeutic effects.

Fe-FeC Functionalized Few-Layer Graphene Sheet Nanocomposites for an Efficient Electrocatalyst of the Oxygen Reduction Reaction.

Preparation of a high-efficiency, low-cost, and environmentally friendly non-precious metal catalyst for the oxygen reduction reaction (ORR) is highly desirable in fuel cells. Herein, a Fe-FeC-functionalized few-layer graphene sheet (Fe/FeC/FLG) nanocomposite was fabricated through the vacuum heat treatment technique using ferric nitrate and glucose as the precursors and exhibited a high-performance ORR electrocatalyst. Multiple characterizations confirm that the nanosized Fe particles with the FeC interface are uniformly distributed in the FLGs.

Suppressor of cytokine signaling 1 (SOCS1) inhibits antiviral responses to facilitate Senecavirus A infection by regulating the NF-κB signaling pathway.

Senecavirus A (SVA) is a new virus inducing porcine idiopathic vesicular disease that causes significant economic losses. Although some progress has been made in etiological research, the role of host factors in SVA infection remains unclear. This study investigated the role of the host factor, suppressor of cytokine signaling 1 (SOCS1), in SVA infection.

Negative Regulators of Inflammation Response to the Dynamic Expression of Cytokines in DF-1 and MDCK Cells Infected by Avian Influenza Viruses.

The H5N1 and H9N2 avian influenza viruses (AIVs) seriously endanger the poultry industry and threaten human health. Characteristic inflammatory responses caused by H5N1 and H9N2 AIVs in birds and mammals result in unique clinical manifestations. The role of anti-inflammatory regulators, PTX3, Del-1, and GDF-15, in H5N1 and H9N2-AIV-mediated inflammation in birds and mammals has not yet been verified.

Phylogenetic and codon usage analysis for replicase and capsid genes of porcine circovirus 3.

Porcine circovirus type 3 (PCV3) is a highly contagious virus belonging to the family Circoviridae that causes the severe dermatitis and nephropathy syndrome. To date, PCV3 has a worldwide distribution and bring huge economic losses to swine industry. Replicase (Rep) and capsid (Cap) are two major coded proteins of PCV3.

Vaccination with virus-like particles of atypical porcine pestivirus inhibits virus replication in tissues of BALB/c mice.

Congenital tremor (CT) type A-II in piglets is a worldwide disease caused by an emerging atypical porcine pestivirus (APPV). Preparation and evaluation of vaccines in laboratory animals is an important preliminary step toward prevention and control of the disease. Here, virus-like particles (VLPs) of APPV were prepared and VLPs vaccine was evaluated in BALB/c mice.

Two Novel Fluorescent Probes as Systematic Sensors for Multiple Metal Ions: Focus on Detection of Hg.

Many precedents prove that fluorescent probes are promising candidates for detection of metal ions in the environment and biological systems. Herein, two novel photoinduced electron transfer (PET)-based fluorescent probes, and , were rationally synthesized by incorporating a triazolyl benzaldehyde moiety into the rhodamine 6G fluorophore. The optical properties of these probes were studied using an ultraviolet-visible (UV-vis) absorption spectrophotometer and a fluorescence spectrophotometer.

Two novel colorimetric fluorescent probes: Hg and Al in the visual colorimetric recognition environment.

Two new dual channel Schiff base fluorescent probes, Tri-R6G and Tri-Flu, were synthesized, and can detect Hg and Al, respectively. The two probes were characterized by FTIR, H NMR, C NMR and HRMS, and their optical properties were detected by UV and FL. Test results showed the probes' detection of Hg and Al compared to other metal ions (Ag, Co, Cd, Mg, Cu, Ni, Ba, Pb, Cr, Al, Zn, Hg, K, Ga and Fe), respectively.

Oleic acid-induced perilipin 5 expression and lipid droplets formation are regulated by the PI3K/PPARα pathway in HepG2 cells.

Perilipin 5 (Plin5), a member of the PAT (Perilipin, ADRP, and Tip47) protein family, has been implicated in the regulation of cellular neutral lipid accumulation in nonalcoholic fatty liver diseases. However, the underlying regulatory mechanisms of Plin5 are not clear. The goal of the present study was to explore the mechanism of oleic acid (OA)-induced Plin5 expression in HepG2 cells.

Pycnogenol® Induces Browning of White Adipose Tissue through the PKA Signaling Pathway in Apolipoprotein E-Deficient Mice.

Beige adipocytes in white adipose tissue (WAT) have received considerable recognition because of their potential protective effect against obesity. Pycnogenol (PYC), extracted from French maritime pine bark, has anti-inflammatory and antioxidant properties and can improve lipid profiles. However, the effect of PYC on obesity has never been explored.