Preliminary Investigation Into the Antidepressant Effects of a Novel Curcumin Analogue (CACN136) In Vitro and In Vivo.

The aim of this study was to develop a novel antidepressant with high activity. Based on the findings of molecular docking, eight novel curcumin analogues were evaluated in vitro to check for antidepressant efficacy. Among them, CACN136 had the strongest antidepressant effect.

Preparation and Evaluation of Curcumin Derivatives Nanoemulsion Based on Turmeric Extract and Its Antidepressant Effect.

Purpose: The early stage of this study verified that a turmeric extract (TUR) including 59% curcumin (CU), 22% demethoxycurcumin (DMC), and 18% bisdemethoxycurcumin (BDMC), could enhance the stability of CU and had greater antidepressant potential in vitro. The objective of the study was to develop a nano-delivery system containing TUR (TUR-NE) to improve the pharmacokinetic behavior of TUR and enhance its antidepressant effect.

Methods: The antidepressant potential of TUR was explored using ABTS, oxidative stress-induced cell injury, and a high-throughput screening model.

The therapeutic value of bifidobacteria in cardiovascular disease.

There has been an increase in cardiovascular morbidity and mortality over the past few decades, making cardiovascular disease (CVD) the leading cause of death worldwide. However, the pathogenesis of CVD is multi-factorial, complex, and not fully understood. The gut microbiome has long been recognized to play a critical role in maintaining the physiological and metabolic health of the host.

Acute pulmonary embolism combined with acute myocardial infarction as the first manifestation of acute leukemia: a case report.

Thrombotic complications in acute myeloid leukemia (AML) are uncommon due to coagulation dysfunction and thrombocytopenia. We report a unique case of AML presenting as concomitant pulmonary embolism and atypical acute myocardial infarction. A 67-year-old male experienced persistent bilateral chest pain.

Case report: Fatal traumatic coronary artery dissection-an overlooked complication of chest fracture.

Coronary artery dissection caused by trauma is a rare occurrence that can be life-threatening. Accordingly, its rapid identification and treatment are essential to improve patient outcomes. Here, we present a case of a patient who suffered multiple rib and femur fractures after falling from a height of eighteen meters and subsequently experienced persistent chest pain.

Progress toward the sustainable development of world cultural heritage sites facing land-cover changes.

The quantification of the extent and dynamics of land-use changes is a key metric employed to assess the progress toward several Sustainable Development Goals (SDGs) that form part of the United Nations 2030 Sustainable Development Agenda. In terms of anthropogenic factors threatening the conservation of heritage properties, such a metric aids in the assessment of achievements toward heritage sustainability solving the problem of insufficient data availability. Therefore, in this study, 589 cultural World Heritage List (WHL) properties from 115 countries were analyzed, encompassing globally distributed and statistically significant samples of "monuments and groups of buildings" (73.

The optimal duration of triple antithrombotic therapy in patients with atrial fibrillation and acute coronary syndrome or undergoing percutaneous coronary intervention: A network meta-analysis of randomized clinical trials.

Background: Triple antithrombotic therapy (TAT) consisting of anticoagulant and dual antiplatelet agents is a core treatment for prevention of ischemic events in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS) or undergoing post-percutaneous coronary intervention (PCI), however, due to bleeding risks, the optimal duration of TAT is unclear.

Methods: We searched the database and conducted a network meta-analysis of randomized controlled trials (RCTs) to determine the optimal duration of TAT for patients with AF and ACS or undergoing PCI by comparing the probability of ischemic and bleeding outcomes for four different TAT durations.

Results: After analyzing data from 12,329 patients, we determined that short-term TAT is advantageous to varying degrees for reducing bleeding events.

Spatial-temporal variations of terrestrial evapotranspiration across China from 2000 to 2019.

Terrestrial evapotranspiration (ET) refers to a key process in the hydrological cycle by which water is transferred from the Earth's surface to lower atmosphere. With spatiotemporal variations, ET plays a crucial role in the global ecosystem and affects vegetation distribution and productivity, climate, and water resources. China features a complex, diverse natural environment, leading to high spatiotemporal heterogeneity in ET and climatic variables.

Primary Exploration of Efficacy of Community-Family Management Mode under Internet-Based Mobile Terminal Monitoring in Elderly Patients with Stable Coronary Heart Disease.

Objective: To explore the efficacy of community-family management mode under Internet-based mobile terminal (MT) monitoring in stable coronary heart disease (CHD) in the elderly.

Methods: A total of 86 patients with stable CHD treated in our hospital from May 2018 to May 2021 were selected as the study objects for the retrospective study and were divided into the control group (routine intervention) and the research group (community-family management mode intervention under Internet MT monitoring) according to the health management modes, with 43 cases each, and the health behaviors and control of CHD were compared between the two groups.

Results: No statistical between-group differences in general information were observed ( > 0.

Ground elevation accuracy verification of ICESat-2 data: a case study in Alaska, USA.

Accurate estimation of ground elevation on a large scale is essential and worthwhile in topography, geomorphology, and ecology. The Ice, Cloud and Land Elevation Satellite-2 (ICESat-2) mission, launched in September 2018, offers an opportunity to obtain global elevation data over the earth's surface. This paper aimed to evaluate the performance of ICESat-2 data for ground elevation retrieval.

LC-UV Determination of Baicalin in Rabbit Plasma and Tissues for Application in Pharmacokinetics and Tissue Distribution Studies of Baicalin after Intravenous Administration of Liposomal and Injectable Formulations.

A simple and sensitive LC-UV method to investigate the pharmacokinetics and biodistribution pattern of baicalin in rabbits was established and validated. Baicalin and the internal standard, rutin, were extracted from biosamples using acetonitrile as protein precipitation after pretreated with ammonium acetate buffer (pH 3.5; 1 M) to obtain a pure chromatographic peak and high extraction recovery.

Difference in LDL receptor feedback regulation in macrophages and vascular smooth muscle cells: foam cell transformation under inflammatory stress.

Macrophages and vascular smooth muscle cells (VSMCs) are the major cell types involved in foam cell formation associated with atherosclerosis. The aim of this experiment was to clarify cell-specific regulation of LDL receptor in THP-1 macrophages and human VSMCs under physiological and inflammatory conditions and its potential mechanisms. Inflammatory stress was induced by adding lipopolysaccharide (LPS) to human THP-1 macrophages and human VSMCs.

Preparation and the in vitro evaluation of nanoemulsion system for the transdermal delivery of granisetron hydrochloride.

The objective of this study was to develop and evaluate nanoemulsion system for transdermal delivery of granisetron hydrochloride. Pseudo-ternary phase diagram was constructed to ascertain the concentration range of components of nanoemulsion composed of isopropyl myristate (IPM) as an oil phase, tween 85 as surfactant, ethanol as cosurfactant, water as aqueous phase. The effects of the content of IPM as an oil phase and n-methyl pyrrolidone (NMP) as transdermal enhancer on rat skin permeation of granisetron hydrochloride nanoemulsion were studied in vitro.

Polymer blends used to prepare nifedipine loaded hollow microspheres for a floating-type oral drug delivery system: in vitro evaluation.

The aim of this study was to investigate whether hollow microspheres prepared from polymer blends of polyvinyl pyrrolidone (PVP) and ethyl cellulose (EC) could improve the vitro release behavior of the poorly water-soluble drug nifedipine. Hollow microspheres containing nifedipine were prepared by a solvent diffusion-evaporation method using various ratios of PVP and EC codissolved with drug in ethanol/ether (5:1, v/v). The hollow microspheres could float in release medium for more than 24 h, and floating capacities were not be influenced by mixing PVP.