Publications by authors named "Wenwen Ying"
Drug resistance is vital for the poor prognosis of acute myeloid leukemia (AML) patients, but the underlying mechanism remains poorly understood. Given the unique microenvironment of bone marrow, we reasoned that drug resistance of AML might rely on distinct metabolic processes. Here, we identify succinate dehydrogenase (SDH) deficiency and over-cumulative succinate as typical features in AML, with a marked function in causing the resistance of AML cells to various anti-cancer therapies.
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- Rhabdomyosarcoma (RMS) is a type of cancer that is most common in kids and teens, but there aren’t many good models to study it yet.
- Researchers collected samples from 51 RMS patients and created 9 new cells that represent the disease, which helps in understanding it better.
- These new cells still have the same genetic changes as the original tumors and can be used to test how well new treatments work, making personalized treatment for RMS patients more possible.
Neddylation is a type of posttranslational protein modification that has been observed to be overactivated in various cancers. UBC12 is one of two key E2 enzymes in the neddylation pathway. Reports indicate that UBC12 deficiency may suppress lung cancer cells, such that UBC12 could play an important role in tumor progression.
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