New Hygrocins K-U and Streptophenylpropanamide A and Bioactive Compounds from the Marine-Associated sp. ZZ1956.

Marine-derived actinomycetes are one of the most important sources for the discovery of novel bioactive natural products. This study characterized the isolation, structural elucidation and biological activity evaluation of thirty compounds, including twelve previously undescribed compounds, namely hygrocins K-U (-, and ) and streptophenylpropanamide A (), from the marine-associated actinomycete sp. ZZ1956.

Copper ferrite nanoparticles loaded on reduced graphene oxide nanozymes for the ultrasensitive colorimetric assay of chromium ions.

Nowadays, due to the increasing threat of heavy metal ion pollution faced by the environment and living systems, the development of rapid and highly selective methods for the detection of chromium ions (Cr) has aroused increasing interest. In this study, copper ferrite nanoparticles (CuFeO) immobilized on reduced graphene oxide (CuFeO/rGO) were successfully fabricated by a simple co-precipitation method. The catalyst exhibits high peroxidase-like activity with 3,3',5,5'-tetramethylbenzidine (TMB) as a chromogenic matrix due to its large specific surface area, adsorption performance and abundant catalytic active sites.

Single-atom palladium anchored N-doped carbon towards oxygen electrocatalysis for rechargeable Zn-air batteries.

Herein, an atomically dispersed palladium catalyst on a hierarchical porous structure of N-doped carbon (Pd/N-C) is prepared using a facile freeze-drying-assisted strategy. Freeze-drying methods not only suppress the aggregation of Pd atoms but also successfully produce abundant nanopores. HAADF-STEM confirms that Pd single atoms are uniformly anchored on the N-C surface.

Antimicrobial metabolites from the Indonesian mangrove sediment-derived fungus sp. ZZ1151.

A total of 14 compounds including a novel tetrasubstituted benzene derivative peniprenylphenol A were isolated from a scaled-up culture of the Indonesian mangrove sediment-derived fungus ZZ1151 in rice medium. Structures of the isolated compounds were determined based on their NMR spectroscopic analyses, HRESIMS data, optical rotation calculations and comparison with the reported data. New peniprenylphenol A () was found to have antimicrobial activities against human pathogenic methicillin-resistant (MRSA), and with MIC values of 6, 13, and 13 µg/mL, respectively.

Cytotoxic metabolites from the marine-associated Streptomyces sp. ZZ1944.

Marine-derived actinomycetes from the genus Streptomycete have a huge potential for the production of metabolites with structural and bioactive uniqueness and diversity. This study described the isolation and structural elucidation of twenty metabolites, including seven previously unreported compounds galbonolide H, galbonolide I, streptophenylpropionic acid A, treptophenylpropyl ester A, streptophenvaleramide A, seco-geldanamycin A and streptorapamycin A, from the marine-associated Streptomycete sp. ZZ1944.

Talaromydien a and talaroisocoumarin A, new metabolites from the marine-sourced fungus sp. ZZ1616.

New talaromydien A and talaroisocoumarin A (), together with nine known compounds (-), were isolated from a culture of the marine-derived sp. ZZ1616 in potato dextrose broth medium. Structures of the new compounds were elucidated based on their HRESIMS data, NMR spectroscopic analyses, the modified Mosher's method, ECD, C NMR and optical rotation calculations.

Bioactive Alkaloids from the Actinomycete sp. ZZ1866.

The new alkaloids marinacarbolines E-Q (-, -), caerulomycin N (), and actinoallonaphthyridine A (), together with the known marinacarboline C () and cyanogramide (), were isolated from the actinomycete sp. ZZ1866. The structures of the isolated compounds were elucidated based on their HRESIMS data, extensive NMR spectroscopic analyses, Mosher's method, ECD calculations, single-crystal X-ray diffraction analysis, and chemical degradation studies.

New Antifungal Metabolites from the Mariana Trench Sediment-Associated Actinomycete sp. SY1965.

New streptothiazolidine A (), streptodiketopiperazines A () and B (), and ()-1-(3-ethylphenyl)-1,2-ethanediol (), together with eight known compounds (-), were isolated from the Mariana Trench sediment-associated actinomycete sp. SY1965. The racemic mixtures of (±)-streptodiketopiperazine ( and ) and (±)-1-(3-ethylphenyl)-1,2-ethanediol ( and ) were separated on a chiral high-performance liquid chromatography (HPLC) column.

Bioactive Metabolites from the Mariana Trench Sediment-Derived Fungus sp. SY2107.

Mariana Trench sediments are enriched in microorganisms, however, the structures and bioactivities of their secondary metabolites are not very known. In this study, a fungus sp. SY2107 was isolated from a sample of Mariana Trench sediment collected at a depth of 11000 m and an extract prepared from the culture of this fungus in rice medium showed antimicrobial activities.

New metabolites from the marine-derived bacterium Pseudomonas sp. ZZ820R.

Six previously undescribed compounds, named monaxanthones A and B, monaphenol A, monathioamide A, monaprenylindole A, and monavalerolactone A, were isolated from the culture of a marine-sourced bacterium Pseudomonas sp. ZZ820R in rice medium. Their structures were elucidated based on the HRESIMS data, NMR and MS-MS spectroscopic analyses, optical rotation and ECD calculations.

A new antimicrobial indoloditerpene from a marine-sourced fungus ZZ761.

A new indoloditerpene () and fifteen known compounds (-) were isolated from a marine-derived fungus ZZ761. Structure of the new compound was elucidated as (3 ,9,12,13,17,18)-2-carbonyl-3-hydroxylemeniveol based on its HRESIMS data, NMR spectroscopic analyses, the Mosher's method, and ECD calculation. This new indoloditerpene () showed antimicrobial activities with MIC values of 20.

Isolation, structural elucidation, and antimicrobial evaluation of the metabolites from a marine-derived fungus sp. ZZ1283.

A crude extract prepared from a culture of marine-sourced fungus ZZ1283 in the medium of potato dextrose broth was found to have antimicrobial activities. Chemical investigation on this active extract resulted in the isolation of eighteen metabolites, including purpuride D, a new analogue of drimane-type sesquiterpene lactones conjugated with -acetyl-L-valine. Structure of the new purpuride D was determined based on its HRESIMS data, NMR spectroscopic analyses, single-crystal X-ray diffraction and ECD calculation.

Bioactive Streptoglutarimides A-J from the Marine-Derived sp. ZZ741.

The new streptoglutarimides A-J (-) and the known streptovitacin A () were isolated from a marine-derived actinomycete, sp. ZZ741. Structures of the isolated compounds were elucidated based on their HRESIMS data, extensive NMR spectroscopic analyses, ECD calculations, Mosher's method, and a single-crystal X-ray diffraction experiment.

Novel Antimicrobial Indolepyrazines A and B from the Marine-Associated sp. ZZ1275.

Two new alkaloids indolepyrazines A () and B () were isolated from the marine-derived sp. ZZ1275. Their structures were elucidated through extensive nuclear magnetic resonance (NMR) spectroscopic analyses, high resolution electrospray ionization mass spectroscopy (HRESIMS) data, and electronic circular dichroism (ECD) calculation.

Peniciphenalenins A-F from the culture of a marine-associated fungus Penicillium sp. ZZ901.

Marine-derived fungi of the genus Penicillium represent a huge potential for synthesizing the secondary metabolites with structural and bioactive uniqueness and diversity. In this study, six previously undescribed compounds peniciphenalenins A-F and four known compounds (+)-sclerodin, (+)-scleroderolide, (+)-sclerodione, and physcion were isolated from the culture of a marine-derived fungus Penicillium sp. ZZ901.

Flexible 3D carbon nanotubes cuff electrodes as a peripheral nerve interface.

The cuff electrode provides a stable interface with peripheral nerves, which has been widely used in basic research and clinical practice. Currently, the cuff electrodes are limited by the planar processing of microfabrication. This paper presents a novel cuff electrode using high-aspect ratio carbon nanotubes (CNTs) integrated on a flexible biocompatible parylene.

3D carbon nanofiber microelectrode arrays fabricated by plasma-assisted pyrolysis to enhance sensitivity and stability of real-time dopamine detection.

In this paper, we have fabricated 3D carbon nanofiber microelectrode arrays (MEAs) with highly reproducible and rich chemical surface areas for fast scan cyclic voltammetry (FSCV). Carbon nanofibers are created from negative photoresist by a new process called dual O plasma-assisted pyrolysis. The proposed approach significantly improves film adhesion and increases surface reactivity.

A flexible and implantable microelectrode arrays using high-temperature grown vertical carbon nanotubes and a biocompatible polymer substrate.

This paper presents a novel microelectrode arrays using high-temperature grown vertically aligned carbon nanotubes (CNTs) integrated on a flexible and biocompatible parylene substrate. A simple microfabrication process is proposed to unite the high quality vertical CNTs grown at high temperature with the heat sensitive parylene substrate in a highly controllable manner. Briefly, the CNTs electrode is encapsulated by two layers of parylene and the device is released using xenon difluoride (XeF2).