SpatialCVGAE: Consensus Clustering Improves Spatial Domain Identification of Spatial Transcriptomics Using VGAE.

The advent of spatially resolved transcriptomics (SRT) has provided critical insights into the spatial context of tissue microenvironments. Spatial clustering is a fundamental aspect of analyzing spatial transcriptomics data. However, spatial clustering methods often suffer from instability caused by the sparsity and high noise in the SRT data.

Inferring single-cell resolution spatial gene expression via fusing spot-based spatial transcriptomics, location, and histology using GCN.

Spatial transcriptomics (ST technology allows for the detection of cellular transcriptome information while preserving the spatial location of cells. This capability enables researchers to better understand the cellular heterogeneity, spatial organization, and functional interactions in complex biological systems. However, current technological methods are limited by low resolution, which reduces the accuracy of gene expression levels.

SpaDiT: diffusion transformer for spatial gene expression prediction using scRNA-seq.

The rapid development of spatially resolved transcriptomics (SRT) technologies has provided unprecedented opportunities for exploring the structure of specific organs or tissues. However, these techniques (such as image-based SRT) can achieve single-cell resolution, but can only capture the expression levels of tens to hundreds of genes. Such spatial transcriptomics (ST) data, carrying a large number of undetected genes, have limited its application value.

Multimodal contrastive learning for spatial gene expression prediction using histology images.

In recent years, the advent of spatial transcriptomics (ST) technology has unlocked unprecedented opportunities for delving into the complexities of gene expression patterns within intricate biological systems. Despite its transformative potential, the prohibitive cost of ST technology remains a significant barrier to its widespread adoption in large-scale studies. An alternative, more cost-effective strategy involves employing artificial intelligence to predict gene expression levels using readily accessible whole-slide images stained with Hematoxylin and Eosin (H&E).

Boundary-Aware Gradient Operator Network for Medical Image Segmentation.

Medical image segmentation is a crucial task in computer-aided diagnosis. Although convolutional neural networks (CNNs) have made significant progress in the field of medical image segmentation, the convolution kernels of CNNs are optimized from random initialization without explicitly encoding gradient information, leading to a lack of specificity for certain features, such as blurred boundary features. Furthermore, the frequently applied down-sampling operation also loses the fine structural features in shallow layers.

Identification of important gene signatures in schizophrenia through feature fusion and genetic algorithm.

Schizophrenia is a debilitating psychiatric disorder that can significantly affect a patient's quality of life and lead to permanent brain damage. Although medical research has identified certain genetic risk factors, the specific pathogenesis of the disorder remains unclear. Despite the prevalence of research employing magnetic resonance imaging, few studies have focused on the gene level and gene expression profile involving a large number of screened genes.

TsImpute: an accurate two-step imputation method for single-cell RNA-seq data.

Motivation: Single-cell RNA sequencing (scRNA-seq) technology has enabled discovering gene expression patterns at single cell resolution. However, due to technical limitations, there are usually excessive zeros, called "dropouts," in scRNA-seq data, which may mislead the downstream analysis. Therefore, it is crucial to impute these dropouts to recover the biological information.

Precise Facial Landmark Detection by Reference Heatmap Transformer.

Most facial landmark detection methods predict landmarks by mapping the input facial appearance features to landmark heatmaps and have achieved promising results. However, when the face image is suffering from large poses, heavy occlusions and complicated illuminations, they cannot learn discriminative feature representations and effective facial shape constraints, nor can they accurately predict the value of each element in the landmark heatmap, limiting their detection accuracy. To address this problem, we propose a novel Reference Heatmap Transformer (RHT) by introducing reference heatmap information for more precise facial landmark detection.

Characteristics of groundwater microbial communities and the correlation with the environmental factors in a decommissioned acid uranium mine.

Microorganisms play an important role in the bioremediation process for the decommissioned acid leaching uranium mine. It is crucial to understand the original microbial community characteristics before the bioremediation. However, there are limited studies on the groundwater microbial characteristics in the decommissioned acid uranium mine.

Network-based cancer genomic data integration for pattern discovery.

Background: Since genes involved in the same biological modules usually present correlated expression profiles, lots of computational methods have been proposed to identify gene functional modules based on the expression profiles data. Recently, Sparse Singular Value Decomposition (SSVD) method has been proposed to bicluster gene expression data to identify gene modules. However, this model can only handle the gene expression data where no gene interaction information is integrated.

TSCCA: A tensor sparse CCA method for detecting microRNA-gene patterns from multiple cancers.

Existing studies have demonstrated that dysregulation of microRNAs (miRNAs or miRs) is involved in the initiation and progression of cancer. Many efforts have been devoted to identify microRNAs as potential biomarkers for cancer diagnosis, prognosis and therapeutic targets. With the rapid development of miRNA sequencing technology, a vast amount of miRNA expression data for multiple cancers has been collected.

A Novel Sparse Graph-Regularized Singular Value Decomposition Model and Its Application to Genomic Data Analysis.

Learning the gene coexpression pattern is a central challenge for high-dimensional gene expression analysis. Recently, sparse singular value decomposition (SVD) has been used to achieve this goal. However, this model ignores the structural information between variables (e.

Edge-group sparse PCA for network-guided high dimensional data analysis.

Motivation: Principal component analysis (PCA) has been widely used to deal with high-dimensional gene expression data. In this study, we proposed an Edge-group Sparse PCA (ESPCA) model by incorporating the group structure from a prior gene network into the PCA framework for dimension reduction and feature interpretation. ESPCA enforces sparsity of principal component (PC) loadings through considering the connectivity of gene variables in the prior network.

Network-Regularized Sparse Logistic Regression Models for Clinical Risk Prediction and Biomarker Discovery.

Molecular profiling data (e.g., gene expression) has been used for clinical risk prediction and biomarker discovery.