Epidemiological and etiological investigation of a rare family cluster caused by severe fever with thrombocytopenia syndrome in Anhui Province in 2023.

Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease discovered in the 21st century. Human-to-human transmission of the disease has been documented, but the mechanisms of transmission require further investigation.

Methods: Epidemiological investigations and genetic analyses of the patients were conducted, and a retrospective cohort study was performed to analyze potential risk factors for person-to-person transmission.

Gut microbiome and plasma metabolome alterations in ileostomy and after closure of ileostomy.

Unlabelled: A temporary loop ileostomy is a routine procedure for protecting the anastomosis in patients undergoing radical resection of rectal cancer. Fecal diversion by a diverting ileostomy may induce microbiota dysbiosis in the defunctioned colon; however, data on temporal and spatial microbiome and metabolome changes in these patients are sparse. Thirty patients who underwent ileostomy closure were enrolled.

Impacts of reproductive systems on grapevine genome and breeding.

Diversified reproductive systems can be observed in the plant kingdom and applied in crop breeding; however, their impacts on crop genomic variation and breeding remain unclear. Grapevine (Vitis vinifera L.), a widely planted fruit tree, underwent a shift from dioecism to monoecism during domestication and involves crossing, self-pollination, and clonal propagation for its cultivation.

Efficient activation of persulfate with bismuth tungstate in dark for degradation of organic pollutants.

Bismuth tungstate (BiWO, BWO) is usually utilized as a photocatalyst for the degradation of various organic pollutants. However, its catalytic potential without light irradiation in persulfate (PS) based advanced oxidation processes (AOPs) has been overlooked, despite its significant redox capacity. Herein, the flower-like orthorhombic BWO was synthesized using a simple hydrothermal method, followed by an evaluation of its catalytic activity in dark through the removal of aqueous organic dye rhodamine B and antibiotic levofloxacin in PS based AOPs.

The application of emerging technologies for the quality and safety evaluation of oilseeds and edible oils.

Oilseeds and edible oils are an indispensable part for the human diet and provide nutritional support for the human health. It has been reported a total of above 170 million tons per annum of edible oils consumption were consumed worldwide. Safety and quality of oilseeds and edible oils cannot be ignored, which can pose risk to human health and cause agro-economic loss.

A force-sensitive adhesion GPCR is required for equilibrioception.

Equilibrioception (sensing of balance) is essential for mammals to perceive and navigate the three-dimensional world. A rapid mechanoelectrical transduction (MET) response in vestibular hair cells is crucial for detecting position and motion. Here, we identify the G protein-coupled receptor (GPCR) LPHN2/ADGRL2, expressed on the apical membrane of utricular hair cells, as essential for maintaining normal balance.

Apolipoprotein D is crucial for promoting perineural invasion in salivary adenoid cystic carcinoma.

Background: Perineural invasion (PNI) is a prevalent phenomenon in salivary adenoid cystic carcinoma (SACC). Nevertheless, the regulatory mechanism of PNI is largely elusive.

Methods: We detected Apolipoprotein D (ApoD) expression and further determined its role in SACC progression.

Glibenclamide targets MDH2 to relieve aging phenotypes through metabolism-regulated epigenetic modification.

Mitochondrial metabolism-regulated epigenetic modification is a driving force of aging and a promising target for therapeutic intervention. Mitochondrial malate dehydrogenase (MDH2), an enzyme in the TCA cycle, was identified as an anti-aging target through activity-based protein profiling in present study. The expression level of MDH2 was positively correlated with the cellular senescence in Mdh2 knockdown or overexpression fibroblasts.

Changes of metabolic syndrome status alter the risks of cardiovascular diseases, stroke and all cause mortality.

Previous research focused primarily on static metabolic syndrome (MetS) status, with less discussion on the effects of its dynamic changes on cardiovascular diseases (CVD), stroke, and all-cause mortality. This study examines the impact of MetS status changes on these health outcomes. This study used data from two prospective cohorts: the China Longitudinal Study of Health and Retirement (CHARLS) and the Wuhan Elderly Health Examination Center community (WEHECC).

The Promoting Effects of Fermented Bile Acid on Growth Performance and Intestinal Health of Through the Modulation of Lipid Metabolism and Gut Microbiota.

Two types of bile acids (BAs), named fermented bile acids (FBAs) and 170HDa, were produced by a biological approach to assess their effects on growth performance, metabolism, and intestinal health in white shrimp. In this study, five experimental diets were prepared with varying levels of FBAs (0.02% for A1, 0.

The dynamic impact of investor climate sentiment on the crude oil futures market: Evidence from the Chinese market.

Climate risk has become a hot topic of global concern. This paper aims to explore the impact of investor climate sentiment (ICS) on China' s crude oil futures market, covering the period from March 27, 2018, to December 30, 2022. Firstly, this paper employs the Thermal Optimal Path (TOP) method and discovers that the guiding effect of ICS on the volatility of crude oil futures (RVoil) intensifies over time, progressively becoming a pivotal factor in determining volatility.

Humidity Induced Proton-Electron Conducting Metal-Organic Frameworks of M(Hexaiminobenzene) (M = Ni, Cu, Fe) for Highly Sensitivity Drug Precursor Chemicals Gases Detection.

Exploiting high-performance gas sensors is desirable for the on-site and accurate detection of drug precursor chemical gases. Here, the electron-proton conductivity metal-organic frameworks M(HIB) were designed to discriminate typical drug precursor chemical gases. The strong d-π conjugation and substantial HO ligands in M(HIB) generate conducting pathways for electrons and protons, which contribute to novel gas-sensing properties.

The chromatin remodeler Brg1 is essential for cochlear sensory epithelium differentiation and patterning.

Human genome analyses have revealed that abnormal BAF (BRG1/BRM-associated factor) complex is highly associated with hearing loss. However, the underlying pathogenesis remains largely unknown. Disrupted structure and function of the organ of Corti is the most prevalent cause of sensorineural hearing loss in mammals.

Decoding the cytokine code for heart failure based on bioinformatics, machine learning and Bayesian networks.

Background: Despite maximal pharmacological treatment guided by clinical guidelines, the prognosis of heart failure (HF) remains poor, posing a significant public health burden. This necessitates uncovering novel pathological and cardioprotective pathways. Targeting cytokines presents a promising therapeutic strategy for HF, yet their intricate mechanisms in HF progression remain obscure.

CD146 promotes resistance of NSCLC brain metastases to pemetrexed via the NF-κB signaling pathway.

Introduction: Pemetrexed is a first line drug for brain metastases from lung cancer, either as monotherapy or combined with other drugs. The frequent occurrence of initial and acquired resistance to pemetrexed results in limited treatment effectiveness in brain metastases. CD146 was recently found to play important roles in chemoresistance and tumor progression.

Wnt signalling facilitates neuronal differentiation of cochlear Frizzled10-positive cells in mouse cochlea via glypican 6 modulation.

Degeneration of cochlear spiral ganglion neurons (SGNs) leads to irreversible sensorineural hearing loss (SNHL), as SGNs lack regenerative capacity. Although cochlear glial cells (GCs) have some neuronal differentiation potential, their specific identities remain unclear. This study identifies a distinct subpopulation, Frizzled10 positive (FZD10+) cells, as an important type of GC responsible for neuronal differentiation in mouse cochlea.

Cyclooxygenase 2 overexpression suppresses Smad3 and augments ERK1/2 signaling activated by TGFβ1 in endometrial stromal cells: A novel insight into endometriosis pathogenesis.

Research Question: To investigate the underlying mechanisms driving the opposing effects of transforming growth factor-beta 1 (TGFβ1) on the proliferation of control (CESCs) and ectopic (EESCs) endometrial stromal cells.

Design: Cell proliferation assays (CCK-8 and colony formation) were employed to assess the effects of TGFβ1 on CESC and EESC proliferation. An immortalized human endometrial stromal cell line (HESC) was used to elucidate the mechanisms behind cytostatic effect of TGFβ1 and the potential role of cyclooxygenase (COX)-2 in mediating the modulation of TGFβ1 signaling.

Impact of Implant Mesiodistal Distance on Peri-Implant Bone Loss: A Cross-Sectional Retrospective Study.

Purpose: The purpose of this study was to verify the effect of our previously proposed mesiodistal distance for multiple posterior implants on preserving peri-implant bone, and to provide a measurable criterion for predicting implant prognosis.

Methods: One hundred and two patients with dental implants placed in the posterior free-end edentulous arches were recruited in this cross-sectional study. Calibrated X-rays (peri-apical [PA] or bite-wing x-ray) were collected to measure the mesiodistal space as well as the corresponding bone resorption of implants after prosthesis placement.

Heterogeneity and therapeutic implications of cancer-associated fibroblasts in lung cancer: Recent advances and future perspectives.

Lung cancer is a leading cause of cancer-related mortality. The tumor microenvironment is a complex and heterogeneous cellular environment surrounding tumor cells, including cancer-associated fibroblasts (CAFs), blood vessels, immune cells, the extracellular matrix, and various cytokines secreted by cells. CAFs are highly heterogeneous and play crucial roles in lung cancer.

Effect of polypropylene microplastics on the performance of membrane bioreactors in wastewater treatment.

Membrane bioreactors (MBRs) can effectively remove microplastics (MPs) because of their good rejection performance. However, the influence of MP concentration and particle size on the short-term and long-term operation efficiency of MBRs remains unclear. To address this issue, this study investigated the effects of short-term stress and long-term accumulation of polypropylene microplastics (PP-MPs) with different particle sizes on the operational efficiency of MBRs by running three MBR systems at four concentration stages.

Correspondence between Euler charges and nodal-line topology in Euler semimetals.

Real multi-bandgap systems have non-abelian topological charges, with Euler semimetals being a prominent example characterized by real triple degeneracies (RTDs) in momentum space. These RTDs serve as "Weyl points" for real topological phases. Despite theoretical interest, experimental observations of RTDs have been lacking, and studies mainly focus on individual RTDs.

Return to work in young and middle-aged colorectal cancer survivors: Factors influencing self-efficacy, fear, resilience, and financial toxicity.

Background: Return to work (RTW) serves as an indication for young and middle-aged colorectal cancer (CRC) survivors to resume their normal social lives. However, these survivors encounter significant challenges during their RTW process. Hence, scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC survivors.

Development of nanofiber facial mask inspired by the multi-function of dried ginger (Zingiberis Rhizoma) essential oil.

Plant extracts, especially herbal extracts, are in line with the cosmetics development trend of natural and safe in today's world. Dried ginger essential oil (DGEO) is a fragrant oily liquid extracted from the dried roots of Zingiber officinale Rosc. This research investigated DGEO could effectively inhibit Staphylococcus aureus and Propionibacterium acnes.

Identification of common diagnostic genes and molecular pathways in endometriosis and systemic lupus erythematosus by machine learning approach and in vitro experiment.

Growing research suggests that endometriosis and systemic lupus erythematosus (SLE) are both chronic inflammatory diseases and closely related, but no studies have explored their common molecular characteristics and underlying mechanisms. Based on GEO datasets, differentially expressed genes in the endometriosis cohort and the SLE cohort were screened using Limma and weighted gene co-expression network analysis (WGCNA), and prediction signatures were constructed using LASSO logistic regression analysis, respectively. Four co-diagnostic genes (PMP22, QSOX1, REV3L, SP110) were identified for endometriosis and SLE.