Background: The global prevalence of child marriage remains high. This systematic review and meta-analysis aims to provide global estimates of the prevalence of intimate partner violence (IPV) among women who are, or have been, child brides (i.e.
View Article and Find Full Text PDFBMC Public Health
February 2025
Background: China has experienced a continuous decline in fertility rates, despite the end of the one-child policy, further intensifying population ageing. Timely evidence on the factors associated with childlessness among Chinese women is needed, alongside examining reproductive anxiety among childless women of reproductive age.
Methods: This nationwide, cross-sectional study was based on the 2023 Psychology and Behavior Investigation of Chinese Residents Survey.
While bullying has significant long-term impacts on mental health, the developmental relationship between empathy and bullying behaviors remains unclear. Specifically, it is uncertain whether bullying perpetration and victimization predict changes in empathy over time or if empathy influences these behaviors. This study addresses this gap by examining the longitudinal dynamic relationship between empathy, bullying perpetration, and victimization.
View Article and Find Full Text PDFSci China Life Sci
January 2025
Ovarian endometrioma (OE), also known as "chocolate cysts," is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations.
View Article and Find Full Text PDFEpithelial-mesenchymal transition (EMT) is known to play a crucial role in the development of endometriosis (EMs). However, the exact mechanisms involved in EMT regulation in EMs are not well understood. In this study, we performed comprehensive research using clinical samples, single-cell sequencing, and in vivo/in vitro models to investigate the effects of advanced oxidation protein products (AOPPs) on EMT and the underlying mechanisms in EMs.
View Article and Find Full Text PDFPredicting drug-target interactions (DTI) is a crucial stage in drug discovery and development. Understanding the interaction between drugs and targets is essential for pinpointing the specific relationship between drug molecules and targets, akin to solving a link prediction problem using information technology. While knowledge graph (KG) and knowledge graph embedding (KGE) methods have been rapid advancements and demonstrated impressive performance in drug discovery, they often lack authenticity and accuracy in identifying DTI.
View Article and Find Full Text PDFAlthough previous studies have shown a close relationship between gaming disorder and depressive symptoms, few have measured normal videogame use, symptoms of gaming disorder, and depressive symptoms concurrently. The longitudinal dynamics between these variables remain unclear. This study used two demographic cohorts to examine the longitudinal relationship between gaming and depressive symptoms: children (n = 1513, 46.
View Article and Find Full Text PDFA growing body of observational studies and Mendelian Randomisation analyses suggest an increased risk of Alzheimer's disease and dementia following COVID-19 infection. However, evidence on the potential association between COVID-19 and vascular dementia, which is plausible given the vascular complications of COVID-19 infection, is still limited. In this study, we conducted a two-sample Mendelian Randomisation analysis to examine the potential causal relationship between COVID-19 phenotypes and the risk of vascular dementia, using summary data from large-scale GWASs.
View Article and Find Full Text PDFAcute kidney injury (AKI) is in high prevalence worldwide but with no therapeutic strategies. Programmed cell death in tubular epithelial cells has been reported to accelerate a variety of AKI, but the major pathways and underlying mechanisms are not defined. Herein, we identified that pyroptosis was responsible for AKI progression and related to ATP depletion in renal tubular cells.
View Article and Find Full Text PDFThe morbidity of polycystic ovary syndrome (PCOS) is in highly increasing rate nowadays. PCOS not only affects the fertility in women, but also threatens the health of whole life. Hence, to find the prognostic risk factors is of great value.
View Article and Find Full Text PDFGlomeruli stand at the center of nephrons to accomplish filtration and albumin interception. Podocytes and mesangial cells are the major constituents in the glomeruli. However, their interdependency in glomerular injury has rarely been reported.
View Article and Find Full Text PDFPolycystic ovary syndrome (PCOS) is a disorder with endocrinal and metabolic problems in reproductive aged women. Evidence shows that PCOS is in a high prone trend to develop kidney diseases. In this study, we investigated the mediators responsible for PCOS-related kidney injury.
View Article and Find Full Text PDFACS Appl Mater Interfaces
May 2022
The expected excellent lubricant effect of graphene in metals during friction and wear is rarely achieved because of the difficulty in synthesizing suitable interfaces. Particularly, the situation is more challenging in titanium (Ti) matrix composites (TMCs) because of the high chemical-interface-reaction tendency between graphene and Ti during composite fabrication. In this study, few-layered graphene (FLG) decorated with SiC nanoparticles (SiCp) was synthesized as reinforcement in Ti-6Al-4V alloy to improve the interface of the composites.
View Article and Find Full Text PDFQ J Exp Psychol (Hove)
January 2023
It has long been debated whether the "congruency sequence effect (CSE)" in conflict tasks such as Flanker could reflect adaptive control. The current study used "mouse tracking" to tackle the issue in a combination of three conflict tasks (i.e.
View Article and Find Full Text PDFJ Exp Psychol Hum Percept Perform
January 2022
Several decades of cognitive research have explored the processes and mechanisms that underlie task switching. Here we report an experiment in which young adult participants were presented with colored shapes, and were randomly cued to categorize them according to color, or to shape. Responses were made via dynamic movements of the computer mouse ("mouse tracking"), which allows insight into how decision making unfolds.
View Article and Find Full Text PDFACS Appl Mater Interfaces
November 2021
Refractory high entropy alloys (RHEAs) have been proven to have excellent mechanical properties with a potential use as protective thin films. However, the combination of high hardness with low friction and wear is a major challenge in the design of RHEA films. In this study, we show that NbMoWTa/Ag self-lubricating multilayered films give a remarkable reduction in friction and at same time maintain high hardness.
View Article and Find Full Text PDFPolycystic ovary syndrome (PCOS) is the most common endocrine disorder in women at reproductive age. However, the underlying pathogenic mechanisms have not been completely understood. Hyperandrogenism is an important clinic feature in patients with PCOS, suggesting its pathologic role in the development and progression of PCOS.
View Article and Find Full Text PDFThe hypothalamus-pituitary-ovary axis is the most important system for regulating female reproductive endocrine function. Its dysfunction would lead to the abnormal secretion of gonadotropin-releasing hormone, follicle-stimulating hormone, or luteinizing hormone, and eventually result in the occurrence of reproductive disease, such as congenital hypogonadotropic hypogonadism, polycystic ovary syndrome, and premature ovarian failure. Recently, an anti-aging gene, Klotho, has gained broad attention in female reproductive diseases.
View Article and Find Full Text PDFMany researchers have shown that renin-angiotensin system (RAS) is involved in various important aspects of male reproduction. In this study, we assessed whether abnormal levels of seminal angiotensinogen (AGT) may be associated with semen parameters in infertile males. A total of 115 male patients were recruited, and semen parameters, seminal AGT and the electrolytes including K , Na , Cl , P and Ca were evaluated.
View Article and Find Full Text PDFNan Fang Yi Ke Da Xue Xue Bao
August 2019
Objective: To study the association of the level of advanced oxidation protein products (AOPPs) in seminal plasma with teratospermia and the outcome parameters of fertilization (IVF).
Methods: We conducted a cross-sectional study among 272 male patients receiving assisted reproduction treatment in the Center for Reproductive Medicine of our hospital between October, 2018 and March, 2019. The levels of seminal AOPPs and reactive oxygen species (ROS), demographic data, sperm parameters and IVF outcome parameters were analyzed for all the patients.
Polycystic ovary syndrome (PCOS) is closely related with the onset and development of metabolic abnormalities. However, the correlation between PCOS and kidney injury has not been clarified, and the underlying mechanism remains unknown. Herein, we performed a prospective survey in 55 PCOS and 69 healthy participants.
View Article and Find Full Text PDFThe increasing amount of scientific literature in biological and biomedical science research has created a challenge in continuous and reliable curation of the latest knowledge discovered, and automatic biomedical text-mining has been one of the answers to this challenge. In this paper, we aim to further improve the reliability of biomedical text-mining by training the system to directly simulate the human behaviors such as querying the PubMed, selecting articles from queried results, and reading selected articles for knowledge. We take advantage of the efficiency of biomedical text-mining, the exibility of deep reinforcement learning, and the massive amount of knowledge collected in UMLS into an integrative artificial intelligent reader that can automatically identify the authentic articles and effectively acquire the knowledge conveyed in the articles.
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