Publications by authors named "Wenting Wu"

Cancer treatment is currently one of the most critical healthcare issues globally. A well-designed drug delivery system can precisely target tumor tissues, improve efficacy, and reduce damage to normal tissues. Stimuli-responsive drug delivery systems (SRDDSs) have shown promising application prospects.

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Covalent inhibition of the KRAS oncoprotein has emerged as a promising therapeutic approach for the treatment of nonsmall cell lung cancer (NSCLC). The identification of KRAS inhibitors has typically relied on the high-throughput screening (HTS) of libraries of cysteine-reactive small molecules or on the attachment of cysteine-reactive warheads to noncovalent binders of KRAS. Such screening approaches have historically been limited in the size and diversity of molecules that could be effectively screened.

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Introduction: SPLASH (NCT04647526) is a multicenter phase III trial evaluating the efficacy and safety of [Lu]Lu-PNT2002 radioligand therapy in metastatic castration-resistant prostate cancer (mCRPC). This study leveraged a lead-in phase to assess tissue dosimetry and evaluate preliminary safety and efficacy, prior to expansion into a randomized phase. Here we report those results.

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  • The study showcases improvements in electrohydrodynamic (EHD) pumps alongside a new 3D-printable organohydrogel designed for soft robotics.
  • Using advanced digital light processing (DLP) technology, the researchers created a manifold pump array that can generate 90.2 kPa of pressure and deliver a flow rate of 800 mL per minute, far exceeding the capabilities of traditional EHD systems.
  • The novel organohydrogel developed has a low swelling ratio, high stretchability, and durability under stress, making it ideal for dynamic applications in soft robotics, bioengineering, and vertical farming.
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An unprecedented Pd-catalyzed cascade alkyne insertion/Heck/C-H activation reaction of -iodophenyl alkenyl ethers and diarylacetylenes has been developed. Diversified tetracyclic-fused dihydroindeno[2,1-]chromenes bearing a quaternary center were constructed in an efficient, straightforward, and atom-economic way with good to excellent yields. The protocol features high bonding efficiency, operational simplicity, broad substrate scope, and easy scale-up.

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The photosynthesis of hydrogen peroxide (HO) from oxygen (O) represents a promising catalytic pathway, the limited efficiency of the oxygen reduction constitutes a primary barrier to enhancing production. In this content, alkali metal potassium (K) and Br-doped g-CN photocatalysts (K-CN) were successfully constructed by one-pot method. The introduction of K is not only beneficial to the transmission of space charge and the separation efficiency of photogenerated carriers, but also promotes the efficient production of HO by 2e oxygen reduction reaction.

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In this work, Mn-Zn-Ni-Mg-Al multi-layer films were annealed in air at different temperatures to form spinel-structured MnZnNiMgAlO high-entropy oxide films. X-ray diffraction results demonstrate that the films possess a polycrystalline spinel phase as well as impurity phases: when annealed at 650 °C and 750 °C, MnO and AlO impurity phases exist; at 950 °C, an AlO impurity phase exists. Only at 850 °C does a pure spinel phase exist.

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GLI1-altered mesenchymal tumors are a relatively rare type of mesenchymal tumor that is common in the head and neck. It is a newly added tumor type in the World Health Organization Tumor Classification of Head and Neck (5th edition). This article reports a case ofGLI1alteredmesenchymal tumor occurring at the left tongue and reviews the relevant literature to summarize the pathological morphological characteristics, immunophenotype, molecular changes, clinical manifestations, and prognosis of the disease.

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  • The relationship between tumor necrosis factor-α inhibitors (TNFi) and cancer risk in psoriasis patients is complex, requiring a careful analysis to understand long-term implications for treatment.
  • This systematic review and meta-analysis assessed the cancer risk associated with long-term TNFi therapy in psoriasis patients, analyzing data from multiple medical databases.
  • The results indicated no significant increase in cancer risk for most types, but highlighted an elevated risk of non-melanoma skin cancer (NMSC) and squamous cell carcinoma (SCC) among those receiving TNFi treatment.
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: Wound management is a critical component of clinical practice. Promoting timely healing of wounds is essential for patient recovery. Traditional treatments have limited efficacy due to prolonged healing times, excessive inflammatory responses, and susceptibility to infection.

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Astrocytes regulate brain functions through gliotransmitters like ATP/ADP and glutamate, but their release patterns and mechanisms remain controversial. Here, we visualized ATP/ADP and glutamate response following astrocyte activation and investigated their mechanisms in vivo. Employing cOpn5-mediated optogenetic stimulation, genetically encoded fluorescent sensors, and two-photon imaging, we observed ATP/ADP released as temporally prolonged and spatially extended flashes that later converted to adenosine.

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The purpose of this study involved the synthesis of supramolecular reservoir (i.e. cyclodextrin metal-organic framework, MOF) using cyclodextrins as building blocks, followed by cross-linking to obtain crosslinked CD framework (CDF) using CD-MOF as template and functionalized with borneol (BO) to enhance rivastigmine (RIV) permeation and facilitate brain targeting via intranasal administration.

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Nanozymes, as promising alternatives to natural enzymes, offer several advantages with biocatalytic functions but remain inferior in catalytic activity. It is crucial to focus on factors that affect the enzymatic activity of nanozymes and develop strategies to make them more competitive with natural enzymes. Herein, CuVO nanorods are confirmed to own the intrinsic laccase-like activity, and an acetonitrile (MeCN)-mediated strategy is proposed for reaction acceleration by mimicking the enzymatic substrate pocket.

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  • - The standard treatment for small-cell lung cancer (SCLC) is platinum-based chemotherapy, which has a high response rate of 50-90%.
  • - Durvalumab, an immune checkpoint inhibitor, is now recommended as a first-line treatment alongside traditional chemotherapy for advanced SCLC, although it can lead to immune-related side effects.
  • - This case report highlights a man in his late 50s with extensive-stage SCLC who developed rare and potentially fatal autoimmune encephalitis after receiving durvalumab treatment, contributing to the understanding of this adverse effect.
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Abdominal wall scar endometriosis (AWE) is a rare endometriosis that usually occurs after gynecological or obstetric surgery and for which surgical resection is the standard treatment. For large tissue defects after resection, abdominal wall reconstruction is needed. Here, we describe a mesh bridging technique using biological and polypropylene meshes for abdominal wall reconstruction.

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  • Researchers focused on how RNA splicing variations could signal differences in protein forms related to type 1 diabetes (T1D), especially in the context of changes in blood circulation.
  • The study utilized machine learning to analyze RNA sequences from blood samples of both new-onset T1D patients and matched controls, revealing distinct splicing patterns linked to the disease.
  • Results indicated that specific RNA splicing events, particularly those with retained introns, were significantly associated with T1D, suggesting these splicing profiles could help understand disease development and differentiate T1D patients from non-diabetics.
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Preparing high-quality perovskite films is a decisive step toward realizing highly efficient and stable perovskite solar cells (Pero-SCs). Water is a key factor affecting the stability of the Pero-SCs. Here, the widely used water adsorbents chitosan, sorbitol, and sodium hyaluronate (NaHA) were used as hydrophilic layers on the upper interface of the perovskite to form a barrier against water.

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Sodium butyrate (NaB) improves β-cell function in preclinical models of diabetes; however, the mechanisms underlying these beneficial effects have not been fully elucidated. In this study, we investigated the impact of NaB on β-cell function and calcium (Ca) signaling using ex vivo and in vitro models of diabetes. Our results show that NaB significantly improved glucose-stimulated insulin secretion in islets from human organ donors with type 2 diabetes and in cytokine-treated INS-1 β cells.

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  • This study looked at how giving birth prematurely (preterm delivery) might lead to kidney problems in mothers later on.
  • The researchers found that women who had preterm deliveries were at a higher risk of chronic kidney disease and end-stage renal disease compared to those who had full-term pregnancies.
  • However, there were only a few studies included, and the researchers said more work is needed to understand this better.
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  • The study investigates the roles of BRG1 and BRM ATPase subunits from the SWI/SNF chromatin remodeling complex in the development of endocrine cells, particularly beta cells, which are crucial for insulin production.
  • Researchers created genetically modified mice to analyze the impacts of removing BRG1 in endocrine progenitor cells and varying levels of BRM deficiency, assessing metabolic health and pancreatic islet function.
  • Findings showed that mice with BRG1 and BRM deficiencies faced severe glucose intolerance and reduced insulin secretion due to diminished islet and hormone-producing cell populations, alongside disrupted gene expression crucial for cell differentiation.
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  • Nonthermal plasma (NTP) can convert methane (CH) and carbon monoxide (CO) into liquid products at mild conditions, but controlling the outcome remains a challenge.
  • The study highlights the effectiveness of a Cu/UiO-66-NH catalyst, which achieved a 53.4% liquid selectivity with a significant portion being C oxygenates (60.8%).
  • The research demonstrates how the catalyst aids in breaking down COOH species, which helps produce ethanol, and reveals that surface-bound CO is more effective than gaseous CO in promoting the necessary chemical reactions for liquid formation.
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The use of tyrosine kinase inhibitors (TKIs) has resulted in significant occurrence of arrhythmias. However, the precise mechanism of the proarrhythmic effect is not fully understood. In this study, we found that nilotinib (NIL), vandetanib (VAN), and mobocertinib (MOB) induced the development of "cellrhythmia" (arrhythmia-like events) in a concentration-dependent manner in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs).

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The precise and controllable preparation of carbon nanomaterials under mild conditions poses a great challenge, especially for metal-catalysed multiphase preparation. This work proposes an efficient method that utilizing high-density ultrasound to enhance the liquid-liquid interfacial reaction system. Iron-doped carbon dots (Fe-CDs) are successfully synthesized in such a normal temperature and atmospheric-pressure reaction condition.

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Purpose: We developed a novel augmented fluoroscopy-guided intrathoracic stamping technique for localizing small pulmonary nodules in the hybrid operating room. We conducted an observational study to investigate the feasibility of this technique and retrospectively compared two augmented fluoroscopy-guided approaches: intrathoracic and transbronchial.

Methods: From August 2020 to March 2023, consecutive patients underwent single-stage augmented fluoroscopy-guided localization under general anaesthesia.

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  • Lupus erythematosus (LE) is a group of autoimmune diseases that can affect the skin, and it's hard for AI to tell the different types apart.
  • Researchers created a new deep learning system to help doctors correctly identify these types of LE and other similar skin conditions using many images and data collected from multiple locations in China.
  • The new system significantly improved the accuracy of doctors in diagnosing LE, raising their success rate from about 67% to over 81%, showing how helpful AI can be in medicine.
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