Publications by authors named "Wenting Lou"
Current status of nucleic acid therapy and its new progress in cancer treatment.
Int Immunopharmacol
December 2024
Article Synopsis
- - Nucleic acids are key molecules in all living cells that store genetic information and help synthesize proteins, with growing recognition of their medical potential in therapy for genetic diseases, viral infections, and cancers.
- - Nucleic acid drugs have emerged as independent therapeutic agents, with 19 approved by the FDA, showcasing various types like antisense oligonucleotides (ASO), mRNA vaccines, and small interfering RNA (siRNA).
- - The review highlights the principles and advantages of nucleic acid therapy, along with its historical development, and points to promising clinical trials involving nucleic acid drugs combined with traditional cancer treatments and immunotherapies for improving outcomes.
Article Synopsis
- Cancer is a major health threat, and nucleic acid therapeutics show promise in regulating gene expression to treat it, potentially leading to tumor remission or cures.
- These therapies have specific mechanisms of action but face challenges like low stability and difficulty crossing physiological barriers in the body.
- The article reviews the structures and principles of nucleic acid drugs, their delivery vectors, and discusses recent advancements, as well as future trends in this area of cancer treatment.
Background: Autism spectrum disorder (ASD) is characterized by impairments in social communication and restricted or repetitive behaviors or interests. ASD is now diagnosed in more than one out of 100 children and is biased towards males by a ratio of at least 4:1. Many possible explanations and potential causative factors have been reported, such as genetics, sex, and environmental factors, although the detailed mechanisms of ASD remain unclear.
View Article and Find Full Text PDFRecent clinical cohort study shows that testosterone therapy increases cardiovascular diseases in men with low testosterone levels, excessive circulating androgen levels may play a detrimental role in the vascular system, while the potential mechanism and effect of testosterone exposure on the vascular function in offspring is still unknown. Our preliminary results showed that perinatal testosterone exposure in mice induces estrogen receptor β (ERβ) suppression in endothelial progenitor cells (EPCs) in offspring but not mothers, while estradiol (E2) had no effect. Further investigation showed that ERβ suppression is due to perinatal testosterone exposure-induced epigenetic changes with altered DNA methylation on the ERβ promoter.
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