Precision Treatment of Metachronous Multiple Primary Malignancies Based on Constructing Patient Tumor-Derived Organoids.

When a patient has two or more primary tumors, excluding the possibility of diffuse, recurrent, or metastatic, they can be defined as having multiple primary malignant neoplasms (MPMNs). Moreover, cases of three primary urinary tract tumors are very rare. Here, we reported a patient of MPMNs with four primary tumors, including three urinary tract cancers (renal cancer, prostate cancer, and bladder cancer) and lung cancer.

Liver segmentation network based on detail enhancement and multi-scale feature fusion.

Due to the low contrast of abdominal CT (Computer Tomography) images and the similar color and shape of the liver to other organs such as the spleen, stomach, and kidneys, liver segmentation presents significant challenges. Additionally, 2D CT images obtained from different angles (such as sagittal, coronal, and transverse planes) increase the diversity of liver morphology and the complexity of segmentation. To address these issues, this paper proposes a Detail Enhanced Convolution (DE Conv) to improve liver feature learning and thereby enhance liver segmentation performance.

Optimal Method to Realize Quantitative Detection of 1D and 2D Nanoassemblies Based on AIE-Active Bolaamphiphilic Molecules.

Controllable transformation between the bolaamphiphilic molecule assemblies with different morphological nanostructures represents an exciting new direction for materials. However, there are still significant challenges for the quantitative detection and real-time monitoring of a controllable nanoself-assembly process due to insufficient measuring methods. Herein, we propose a new and effective fluorescence technology for realizing quantitative detection of a controllable conversion process of one-dimensional (1D)/two-dimensional (2D) nanoassemblies by introducing AIEgens as the fluorescence signal part.

Spin polarization induced by atomic strain of MBene promotes the ·O production for groundwater disinfection.

Superbugs in groundwater are posing severe health risks through waterborne pathways. An emerging approach for green disinfection lies at photocatalysis, which levers the locally generated superoxide radical (·O) for neutralization. However, the spin-forbidden feature of O hinders the photocatalytic generation of active ·O, and thus greatly limited the disinfection efficiency, especially for real groundwater with a low dissolved oxygen (DO) concentration.

Egg white protein‑sodium alginate smart labels based on pH-driven method and nonphase change 3D printing in mackerel freshness response.

The smart labels prepared via the casting method and molten 3D printing method have a long heating time at high temperature and a dense network structure, resulting in a decrease in the color response ability of the labels. Therefore, this study uses a nonphase change foam 3D printing method with a shorter heating time to improve the color sensitivity of smart labels. By the pH driving method, the blending and pregelation of sodium alginate (Alg) can extend the drainage time of the interfacial film to the maximum extent, thus further improving the foam stability of egg white protein (EWP) and endowing the interfacial adsorption layer with better flexibility and fluidity.

Improving the emulsification properties of corn starch by esterification combined with freeze-thawing and enzymatic treatment.

In this study, high performance porous starch was prepared by combining freeze-thawing and enzymatic hydrolysis with the aim of evaluating its potential as a starch emulsifier in Pickering emulsions. The results indicate that the combined treatment significantly altered the specific surface area of starch (from 0.3257 m/g to 1.

Diabetes mediates the relationship between cardiometabolic index and kidney stones: a cross-sectional study.

Previous studies have shown that diabetes is one of the risk factors for kidney stone formation. The Cardiometabolic Index (CMI) is a composite index used to assess an individual's cardiovascular health and metabolic status. CMI has been associated with several metabolic diseases.

Enhancing electricity generation and pollutant degradation in microbial fuel cells using cyanobacteria-derived biochar electrodes.

Utilizing microbial fuel cells (MFCs) technology to simultaneously achieve efficient biopower generation and pollutant degradation is a persistent pursuit. However, the limited rate of extracellular electron transfer (EET) and the availability of electrode materials remain key factors limiting the practical application of MFCs. In this article, modified carbon derived from cyanobacteria is applied to modify electrodes and assemble MFCs.

Research on Video Monitoring Technology for Galloping of OCS Additional Conductors of High-Speed Railway in Strong Wind Zone.

The strong wind environment causes the additional conductor of the overhead contact system (OCS) of the Lanzhou-Xinjiang high-speed railway to gallop, significantly impacting the safe operation of the train. This paper presents the design of an online monitoring system for the galloping of additional conductors in the OCS, utilizing video monitoring for accurate and real-time assessment. Initially, the dynamics of the OCS additional conductor and its operational environment are examined, leading to the selection of suitable data transmission and power supply methods to finalize the camera configuration.

Association of R3HDM1 variants with growth and meat quality traits in Qinchuan cattle and its role in lipid accumulation.

The R3H domain containing 1 (R3HDM1) gene has emerged as a candidate influencing residual feed intake and beef yield. Despite this, the genetic variation of R3HDM1 and its effects on beef cattle remain unexplored. This study identified four single nucleotide polymorphisms (SNPs) in the R3HDM1 gene of Qinchuan cattle, with the g.

Konjac glucomannan and κ-carrageenan improve hepatic fatty acid metabolism and colonic microbiota in suckling piglet.

Konjac glucomannan (KGM) and κ-carrageenan are polysaccharides that have garnered attention for their potential health benefits. This study aimed to evaluate the maternal supplementation of KGM and κ-carrageenan (SF) during later gestation and lactation on the effect of hepatic lipid metabolism and colonic microflora in offspring. Regarding antioxidant and inflammatory factors in the suckling piglet liver, our results showed that nuclear factor erythroid 2-related factor 2 (Nrf2) and interleukin (IL)-10 levels were significantly increased in the SF group (P < 0.

1+1<2: Combined effect of low temperature stress and salt stress on Sesuvium portulacastrum L.

To expedite the deployment of Sesuvium portulacastrum floating bed technology in Hangzhou Bay and the Yangtze River Estuary, and to overcome the cryogenic constraint, our study concentrated on investigating the impacts of both individual and combined stress factors, particularly low temperature and salinity, on its application. We detected the S. portulacastrum related enzyme activity and other biological macromolecules under low temperature stress, salt stress and combined stress.

Acetyltransferase NAT10 promotes an immunosuppressive microenvironment by modulating CD8 T cell activity in prostate cancer.

N-acetyltransferase 10 (NAT10), an enzyme responsible for ac4C acetylation, is implicated in cancer progression, though its specific biological function in prostate cancer remains insufficiently understood. This study clarifies NAT10's role in prostate cancer and its effects on the tumor immune microenvironment. NAT10 expression and clinical relevance were assessed through bioinformatics, RT-qPCR, and IHC analyses, comparing prostate cancer tissues with normal controls.

Maternal supplementation with konjac glucomannan and κ-carrageenan promotes sow performance and benefits the gut barrier in offspring.

This research aims to investigate the effects of dietary konjac glucomannan and κ-carrageenan (SF) on sow performance and suckling piglet gut barrier. Thirty-four sows in late gestation (parity 2-5) were selected at random and grouped into two treatments. The control group (Con group;  = 17) was fed the basal diet; the SF group was fed the same diet supplemented with 0.

Characterization of dipyridamole as a novel ferroptosis inhibitor and its therapeutic potential in acute respiratory distress syndrome management.

: Ferroptosis in lung epithelium and endothelium contributes to the pathogenesis of acute respiratory distress syndrome (ARDS), a critical and often fatal condition marked by acute inflammation and elevated pulmonary vascular permeability. Despite this, there are currently no FDA-approved therapeutics specifically targeting ferroptosis for ARDS management. : A screening of 259 FDA-approved drugs was conducted to identify an effective ferroptosis inhibitor in pulmonary epithelial and endothelial cells.

Effect of co-pigments on anthocyanins of wild cranberry and investigation of interaction mechanisms.

This study systematically evaluated the color-enhancing effects of different co-pigmented molecules (amino acids, peptides, flavonoids and phenolic acids) with cranberry anthocyanins under different environmental conditions (light, dark, high temperature and ascorbic acid) and their potential mechanisms by various means, such as degradation kinetics, color stability, H NMR spectroscopy, and structural simulation analyses. The results showed that the introduction of co-pigments induced a strong color-enhancing effect and bathochromic shift, inhibited the degradation of anthocyanins (9.34 % ∼ 45.

Sensitive and portable intelligent detection platform construction and dietary risk assessment of procymidone in Chinese leek, cowpea and celery.

Procymidone (PRM), a widely used amide-type fungicide in vegetables, poses potential health risks due to its high detection rate. This study introduces a pretreatment device and an intelligent quantification method for PRM in Chinese leek, cowpea, and celery using a lateral flow immunoassay (LFIA) integrated with a smartphone. The whole pretreatment and detection process can be achieved within 21 min.

A wearable osmotic microneedle patch provides high-capacity sustained drug delivery in animal models.

The maintenance of stable plasma drug concentrations within a therapeutic window can be critical for drug efficacy. Here, we developed a wearable osmotic microneedle (OMN) patch to support sustained drug dosing for at least 24 hours without the use of electronic components. The OMN patch uses an osmotic pressure driving force to deliver drug solution into the skin through three hollow microneedles with diameters of less than 200 micrometers.

easySCF: a tool for enhancing interoperability between R and Python for efficient single-cell data analysis.

Summary: This study introduces easySCF, a tool designed to enhance the interoperability of single-cell data between the two major bioinformatics platforms, R and Python. By supporting seamless data exchange, easySCF improves the efficiency and accuracy of single-cell data analysis.

Availability And Implementation: easySCF utilizes a unified data format (.

Chinese knot inspired isotropic linear scanning method for improved imaging performance in AFM.

Atomic force microscope (AFM) is an important nano-scale surface characterization and measurement method. Raster scanning method (RSM), widely used in AFMs, faces limitations on scanning speed and imaging accuracy. In this paper, an isotropic linear scanning method (ILSM) is proposed to improve the AFM imaging performance.