Publications by authors named "Wentao Zhan"
The role of glioma-associated myeloid cells in tumor growth and immune evasion remains poorly understood. We performed single-cell RNA sequencing of immune and tumor cells from 33 gliomas, identifying two distinct myeloid-derived suppressor cell (MDSC) populations in isocitrate dehydrogenase-wild-type (IDT-WT) glioblastoma: an early progenitor MDSC (E-MDSC) population with up-regulation of metabolic and hypoxia pathways and a monocytic MDSC (M-MDSC) population. Spatial transcriptomics demonstrated that E-MDSCs geographically colocalize with metabolic stem-like tumor cells in the pseudopalisading region.
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- Regulatory T cells (T) are traditionally seen as suppressors of antitumor immunity, but their influence on immune checkpoint blockade (ICB) responses remains uncertain.
- This study used advanced sequencing techniques to analyze over 73,000 tumor-infiltrating T cells from both anti-PD-1 treated and untreated lung cancer patients, identifying 10 distinct T cell subsets, with one subset showing high expression of activation markers linked to immune suppression.
- The findings suggest that not all TIL-Ts are detrimental; a specific subset may help enhance responses to therapy, illustrating the complex role of TIL-Ts in cancer treatment.
Herein, we have developed an efficient tungsten-catalyzed homogeneous system for oxidative dehydrogenative coupling of anilines to selectively produce various azoaromatics and azoxyaromatics as well as 2-substituted indolone -oxides by simply regulating the reaction solvent with peroxide as a terminal oxidant under additive-free conditions. These findings provide an experimental framework for exploring tungsten catalysis in organic synthesis and offer an efficient and convenient tactic for the selective oxidation of anilines.
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