Tumor-associated macrophages (TAMs) are a critical component of the immunosuppressive tumor microenvironment, comprising monocyte-derived macrophages (MDM-TAMs) and tissue-resident macrophages (TRM-TAMs). Here, we discovered that TRM-TAMs mediate the pro-tumor effects of interleukin (IL)-17A and that IL-17A-driven tumor progression requires tumor cell production of osteopontin (OPN). Mechanistically, we identified CEBPβ as a transcription factor downstream of IL-17A in tumor cells and LYVE-1 as an OPN receptor on TRM-TAMs.
View Article and Find Full Text PDFBackground: Neuropathic pain (NPP) is a multifaceted pain syndrome that occurs as a consequence of physical injury or underlying diseases, with an incidence rate of 7%-10%, NPP poses a significant clinical challenge as current treatment options are ineffective. The accumulation of apoptotic cells and neuroinflammation play crucial roles in the pathological mechanisms of NPP. Here, we aim to investigate strategies for effectively clearing apoptotic cells and provide therapeutic interventions for NPP.
View Article and Find Full Text PDFNeutrophil extracellular traps (NETs) have been shown to exhibit chemotactic effects on circulating tumor cells at metastatic sites, promoting the progression of colorectal cancer liver metastasis (CRLM). However, the origin and factors contributing to the formation of NETs (NETosis) in the pre-metastatic niche (PMN) of target organs remain unclear. In this study, we investigated the relationship between phosphatase of regenerating liver-3 (PRL-3), myeloid-derived suppressor cells (MDSCs), neutrophils, and NETs through a retrospective clinical cohort study and a mouse model of CRLM.
View Article and Find Full Text PDFIntegrating abundant dual sites of hydrazine oxidation reaction (HzOR) and hydrogen evolution reaction (HER) into one catalyst is extremely urgent toward energy-saving H production. Herein, CoSe-NiSe heterostructure coupling with TiCT MXene (CoSe-NiSe/MXene) is fabricated on nickel foam (NF) to enhance the catalytic performance. The heterogeneous CoSe-NiSe and MXene coupling effect can change the coordination of Ni and Co, resulting in adjusted interfacial electronic field and enhanced electron transfer from NiSe to CoSe especially near MXene surface.
View Article and Find Full Text PDFClear cell renal cell carcinoma (ccRCC), the most common subtype of renal cell carcinoma, often exhibits resistance to tyrosine kinase inhibitors (TKIs) when used as monotherapy. However, the integration of PD-1 blockade with TKIs has significantly improved patient survival, making it a leading therapeutic strategy for ccRCC. Despite these advancements, the efficacy of this combined therapy remains suboptimal, necessitating a deeper understanding of the underlying regulatory mechanisms.
View Article and Find Full Text PDFBiochim Biophys Acta Mol Basis Dis
January 2025
Mitochondrial dynamics plays a crucial role in the occurrence and development of non-alcoholic fatty liver diseases (NAFLD). SENP1, a SUMO-specific protease, catalyzes protein de-SUMOylation and involves in various physiological and pathological processes. However, the exact role of SENP1 in NAFLD remains unclear.
View Article and Find Full Text PDFMastitis is an important factor affecting the health of cows that leads to elevated somatic cell counts in milk, which can seriously affect milk quality and result in huge economic losses for the livestock industry. Therefore, the aim of this trial was to investigate the effect of melatonin on performance and mastitis in dairy cows. Forty-eight Holstein cows with a similar body weight (470 ± 10 kg), parity (2.
View Article and Find Full Text PDFTwo-dimensional conductive MOF thin films have attracted attention due to their rich pore structure and unique electrical properties, and their applications in many fields, including batteries, sensing, supercapacitors, electrocatalysis, etc. This paper discusses several preparation methods for 2D conductive MOF thin films. And the applications of 2D conductive MOF thin films are summarized.
View Article and Find Full Text PDFPrenyltransferases play a pivotal role in the isoprenoid biosynthesis and transfer in insects. In the current study, two classes of prenyltransferases (MhieFPPS1 and MhieFPPS2, MhiePFT-β and MhiePF/GGT-α) were identified in the leaf beetle, Monolepta hieroglyphica. Phylogenetic analysis revealed that MhieFPPS1, MhieFPPS2, MhiePFT-β and MhiePF/GGT-α were clustered in one clade with homologous in insects.
View Article and Find Full Text PDFSensors (Basel)
September 2024
Photo-transduction of solid-state optoelectronics occurs in semiconductors or their interfaces. Considering the confined active area and interfacial capacitance of solid-state materials, solid-state optoelectronics faces inherent limitations in photo-transduction, especially for bionic vision, and the performance is lower than that of living systems. For example, a photoreceptor generates pA-level photocurrent when absorbing a single photon.
View Article and Find Full Text PDFColloids Surf B Biointerfaces
January 2025
Bone defect has always been a difficult problem in clinical work. According to the current research results, tissue engineered scaffolds with a single function, structure, and composition are not sufficient to repair complex bone defects. In this work, a three-dimensional (3D) chitosan degradable composite scaffold loaded with zinc oxide (ZnO) was constructed, and the effect of ZnO content on scaffold performance and osteogenesis was explored.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2024
Guided bone regeneration (GBR) technology has been demonstrated to be an effective method for reconstructing bone defects. A membrane is used to cover the bone defect to stop soft tissue from growing into it. The biosurface design of the barrier membrane is key to the technology.
View Article and Find Full Text PDFThis paper aims to study the maglev force and vibration attenuation characteristics of quasi-zero stiffness cruciform maglev isolators (CMIs). The maglev force and stiffness of CMIs were analytically computed based on equivalent charge theory, and the transfer function of the system was conducted. The effects of magnet geometry parameters and air gap on the maglev force, stiffness, and vibration transmission characteristics of the CMI system were revealed through parametric analyses.
View Article and Find Full Text PDFThe Nb-16Si-24Ti-2Al-2Cr alloy was prepared by plasma rotating electrode process (PREP) technology and the hot-pressing (HP) method, and the effects of sintering temperature on the microstructure, mechanical properties and fracture behavior were investigated. The HP alloys sintered at temperatures below 1400 °C are composed of Nbss (Nb solid solution), NbSi and NbSi phases. When the sintering temperature reaches 1450 °C, the NbSi phase is completely decomposed into Nbss and NbSi phases.
View Article and Find Full Text PDFInt J Biol Macromol
November 2024
With the development in the field of biomaterials, research on alternative biocompatible materials has been initiated, and alginate in polysaccharides has become one of the research hotspots due to its advantages of biocompatibility, biodegradability and low cost. In recent years, with the further understanding of microscopic molecular structure and properties of alginate, various physicochemical methods of cross-linking strategies, as well as organic and inorganic materials, have led to the development of different properties of alginate hydrogels for greatly expanded applications. In view of the potential application prospects of alginate-based hydrogels, this paper reviews the properties and preparation of alginate-based hydrogels and their major achievements in delivery carrier, dressings, tissue engineering and other applications are also summarized.
View Article and Find Full Text PDFSupercapacitors (SCs) are widely recognized as competitive power sources for energy storage. The hierarchical structure of nickel vanadium sulfide nanoparticles encapsulated on graphene nanosheets (NVS/G) was fabricated using a cost-effective and scalable solvothermal process. The reaction contents of the composites were explored and optimized.
View Article and Find Full Text PDFPrior research highlights the critical role of AI in enhancing second language (L2) learning. However, the factors that practically affect L2 learners to engage with AI resources are still underexplored. Given the widespread availability of digital devices among college students, they are particularly poised to benefit from AI-assisted L2 learning.
View Article and Find Full Text PDF