Publications by authors named "Wenshu Chen"

Article Synopsis
  • Limited research has been done on how copper (Cu) interacts with pH levels and affects gene expression and metabolite profiles in plant roots.
  • In an experiment, seedlings were exposed to either toxic (300 μM) or control (0.5 μM) copper chloride at different pH levels (3.0 and 4.8) for 17 weeks, revealing that a higher pH reduced Cu's toxic effects on metabolites in roots.
  • The study found that increased pH helped roots manage Cu levels better, reduced oxidative stress, and mitigated damage and growth impairment caused by Cu, while also showing differences and similarities in gene and metabolite responses between roots and leaves.
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  • The study investigates how plant hormones and energy-rich compounds help Citrus sinensis leaves cope with aluminum toxicity at different pH levels, revealing more adaptive responses at pH 4.0 compared to pH 3.0.
  • At pH 4.0, a greater number of hormones and compounds were found to be responsive to aluminum toxicity, indicating that a higher pH enhances the plant's ability to manage Al stress.
  • The improved resilience includes enhanced leaf growth, better detoxification of aluminum and reactive oxygen species, and maintenance of energy compound levels, highlighting the critical role of hormones and metabolites in plant health during aluminum stress.
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  • Citrus orchards in China face nitrogen deficiency, impacting hormone levels in sweet orange plants, specifically in leaves and roots.
  • Targeted metabolomics revealed that N deficiency leads to decreased levels of gibberellins and IAA, while increasing OPDA, ethylene, and salicylic acid, which may cause reduced growth and quicker leaf aging.
  • Adjustments in hormones due to N deficiency also affected the root/shoot dry weight ratio and root system architecture, ultimately improving the plant's nitrogen use efficiency and tolerance to low nitrogen conditions.
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Rechargeable aqueous zinc batteries are promising in next-generation sustainable energy storage. However, the low zinc (Zn) metal anode reversibility and utilization in aqueous electrolytes due to Zn corrosion and poor Zn deposition kinetics significantly hinder the development of Zn-ion batteries. Here, a dual salt/dual solvent electrolyte composed of Zn(BF)/Zn(Ac) in water/TEGDME (tetraethylene glycol dimethyl ether) solvents to achieve reversible Zn anode at an ultrahigh depth of discharge (DOD) is developed.

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Introduction: Atrial fibrillation (AF) is a common arrhythmia, with radiofrequency catheter ablation (RFCA) being first-line therapy. However, the high rate of post-ablation recurrence necessitates the identification of predictors for recurrence risk. Left atrial low-voltage areas (LA-LVASs), reflecting atrial fibrosis, have been confirmed to be related to recurrence of AF.

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Circadian homeostasis in mammals is a key intrinsic mechanism for responding to the external environment. However, the interplay between circadian rhythms and the tumor microenvironment (TME) and its influence on metastasis are still unclear. Here, in patients with colorectal cancer (CRC), disturbances of circadian rhythm and the accumulation of monocytes and granulocytes were closely related to metastasis.

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To investigate the molecular mechanism of the defense response of "Cabernet Sauvignon" grapes to feeding by , high-throughput sequencing technology was used to analyze the transcriptome of grape leaves under three different treatments: feeding by , puncture injury, and an untreated control. The research findings indicated that the differentially expressed genes were primarily enriched in three aspects: cellular composition, molecular function, and biological process. These genes were found to be involved in 42 metabolic pathways, particularly in plant hormone signaling metabolism, plant-pathogen interaction, MAPK signaling pathway, and other metabolic pathways associated with plant-induced insect resistance.

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Background: The effect of two lung ventilation (TLV) with carbon dioxide artificial pneumothorax on cerebral desaturation and postoperative neurocognitive changes in elderly patients undergoing elective minimally invasive esophagectomy (MIE) is unclear.

Objectives: The first aim of this study was to compare the effect of TLV and one lung ventilation (OLV) on cerebral desaturation. The second aim was to assess changes in early postoperative cognitive outcomes of two ventilation methods.

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Nanoconfinement of cations in layered oxide cathode is an important approach to realize advanced zinc ion storage performance. However, thus far, the conventional hydrothermal/solvothermal route for this nanoconfinement has been restricted to its uncontrollable phase structure and the difficulty on the multiple cation co-confinement simultaneously. Herein, this work reports a general, supramolecular self-assembly of ultrathin VO nanosheets using various unitary cations including Na, K, Mg, Ca, Zn, Al, NH , and multiple cations (NH + Na, NH + Na + Ca, NH + Na + Ca +Mg).

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The roles of platelets/megakaryocytes (MKs), the key components in the blood system, in the tumor microenvironment and antitumor immunity are unclear. In patients with colorectal cancer, the number of platelets was significantly increased in patients with metastasis, and Erbin expression was highly expressed in platelets from patients with metastases. Moreover, Erbin knockout in platelets/MKs suppressed lung metastasis in mice and promoted aggregations of platelets.

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Anaplastic lymphoma kinase tyrosine kinase inhibitors (ALK-TKIs) have demonstrated substantial effectiveness in individuals with advanced ALK-positive non-small cell lung cancer (NSCLC). However, the controversy over using ALK-TKIs for neoadjuvant therapy in ALK-positive NSCLC has not been fully explored. This case study describes the clinical progression of a patient initially diagnosed with unresectable stage III (cT1bN2M0) lung adenocarcinoma, who was later discovered to harbor an ALK mutation through next-generation sequencing.

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Convolutional Neural Networks (CNNs) have achieved remarkable progress in arbitrary artistic style transfer. However, the model size of existing state-of-the-art (SOTA) style transfer algorithms is immense, leading to enormous computational costs and memory demand. It makes real-time and high resolution hard for GPUs with limited memory and limits the application on mobile devices.

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Background: Benign anastomotic strictures (BAS) significantly impact patients' quality of life and long-term prognosis. However, the current clinical practice lacks accurate tools for predicting BAS. This study aimed to develop a machine-learning model to predict BAS in patients with rectal cancer who have undergone anterior resection.

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Background: Non-small cell lung cancer (NSCLC) with mutations has a worse prognosis. It was generally more resistant to chemotherapy and radiation. Our aim was to investigate the correlation between the co-mutated gene and clinical features, and prognostic value in patients with NSCLC.

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Background: Esophageal carcinoma accompanied by a right aortic arch (RAA) is very rare. When combined with Kommerell diverticulum (KD), a right aortic arch forms a vascular ring encircling both the esophagus and trachea. Due to abnormal anatomy of the upper mediastinum, it is very difficult to dissociate the esophagus and its surrounding tissues, especially the left recurrent laryngeal nerve.

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Article Synopsis
  • Boron (B) helps citrus plants deal with toxic levels of copper (Cu), but the exact mechanism is not well understood.
  • In a study with 'Xuegan' citrus seedlings, researchers explored how B affected the secretion of low molecular weight compounds (LMWCs) from roots and their concentrations in roots and leaves while exposing them to control (0.5 µM) and high (350 µM) Cu levels.
  • The results showed that while Cu-stress increased the release of certain LMWCs, B didn't enhance this release and even reduced malate secretion; however, B increased the concentrations of some LMWCs in Cu-stressed roots, indicating an internal detoxification process for mitigating Cu-toxicity
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Article Synopsis
  • Seedlings were grown with either 15 mM (control) or 0 mM nitrogen for 10 weeks, leading to significant changes in root metabolism and gene expression in nitrogen-deficient plants.
  • The nitrogen-deficient roots enhanced phosphate homeostasis, improved nitrogen balance by modifying compound ratios, and promoted energy production while reducing energy consumption for growth.
  • Additionally, these roots exhibited better detoxification of harmful substances, which helped protect them from oxidative damage and delayed aging.
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Background: With the increasing availability of chest computed tomography (CT), the detection of small pulmonary nodules has become more common, facilitating the development of lung segmental resection. However, anatomical variations of the bronchi are common, particularly in the right upper lobe of the lung.

Case Presentation: We report a case of thoracoscopic resection of the posterior segment of the right upper lobe of the lung.

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Denoising is one of the most significant procedures in the image processing pipeline. Nowadays, deep-learning-based algorithms have achieved superior denoising quality than traditional algorithms. However, the noise becomes severe in the dark environment, where even the SOTA algorithms fail to achieve satisfactory performance.

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Although deep learning-based (DL-based) image processing algorithms have achieved superior performance, they are still difficult to apply on mobile devices (e.g., smartphones and cameras) due to the following reasons: 1) the high memory demand and 2) large model size.

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Introduction: The impact of rib invasion on the non-small cell lung cancer (NSCLC) T classifications remains unclear. Our study aims to verify the impact of rib invasion on survival in patients with NSCLC through multicenter data from the Surveillance, Epidemiology, and End Results (SEER) database, and proposed a more appropriate pT for the forthcoming 9 tumor-node-metastasis (TNM) classifications.

Method: The SEER database was used to collect TNM NSCLC cases from the period of 2010-2015 according to the 7 TNM classification system.

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Background: Ubiquitination is an important regulator in physiological and pathological conditions. Ubiquitin-specific protease 2 (USP2), as a member of the USP family, exhibits oncogenic effects in multiple malignancies. However, the exact role of USP2 has not been well clarified in lung cancer pathogenesis and progression.

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Ag nanoparticle was found to significantly enhance the photocatalytic activity of self-organized TiO nanotube structures. Herein, novel Ag/TiO tube-in-tube fibers have been prepared by a facile electrospinning technology and calcination process. Employed as the photocatalyst, the composite could efficiently catalyze the photodegradation of the model organic pollutant, rhodamine B under visible light irradiation, exhibiting a superior photocatalytic activity than the undoped TiO tube-in-tube fibers.

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Among metals used for CO electroreduction in water, Cu appears to be unique in its ability to produce C2+ products like ethylene. Bimetallic combinations of Cu with other metals have been investigated with the goal of steering selectivity creating a tandem pathway through the CO intermediate or by changing the surface electronic structure. Here, we demonstrate a facile cation exchange method to synthesize Ag/Cu electrocatalysts for CO reduction using Cu sulfides as a growth template.

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