LaF@SiO yolk-shell heterostructure nanofiber-modified separator enhances the long-cycling performance of lithium-sulfur batteries.

High-energy-density lithium-sulfur (Li-S) cells are identified as one of the most prospective next-generation energy storage appliances owing to their numerous advantages. Nonetheless, their widespread applications are restricted by the unwanted shuttling effect and tardy conversion reaction kinetics of lithium polysulfides (LiPSs). To address these puzzles, we present an innovative strategy for the one-pot synthesis of LaF@SiO yolk-shell heterostructure nanofibers (YSHNFs) through a straightforward uniaxial electrospinning process coupled with fluorination, avoiding the complexities of traditional methods.

Rapid Affinity and Microsomal Stability Ranking of Crude Mixture Libraries of Histone Deacetylase Inhibitors.

The science of drug discovery involves multiparameter optimization of molecular structures through iterative design-make-test cycles. For medicinal chemistry library synthesis, traditional workflows involve the isolation of each individual compound, gravimetric quantitation, and preparation of a standard concentration solution for biological assays. In this work, we explore ways to expedite this process by testing unpurified library mixtures using a combination of mass spectrometry-based assays for affinity selection and microsomal metabolic stability.

Complete genome sequence of Kushneria phosphatilytica YCWA18 reveals the P-solubilizing activity of the genus Kushneria.

Kushneria phosphatilytica YCWA18 (= CGMCC 1.9149 = NCCB 100306) was isolated from sediment collected in a saltern on the eastern coast of Yellow Sea in China. The genome was sequenced and comprised of one circular chromosome with the size of 3,624,619 bp and DNA G + C content of 59.

CeO/Co heterostructure encapsulated in hollow necklace-like carbon fiber as an advanced host material for high-performance lithium-sulfur batteries.

The shuttle effect of lithium polysulfides (LiPSs) and the sluggish reaction kinetics of LiPSs conversion pose serious challenges to the commercial feasibility of lithium-sulfur (Li-S) batteries. To address these obstacles, herein, we construct CeO/Co heterostructures in hollow necklace-like carbon fibers (CeO/Co-CNFs) as the cathode host material for Li-S batteries. The specific surface area of fibers is significantly enhanced by using a template, thereby promoting the utilization efficiency of sulfur.

CsPbBr perovskite quantum dots-based Janus membrane with multifunction of luminescence, magnetism and aeolotropic electroconductivity.

Lead halide perovskite quantum dots (QDs) are promising semiconductors for next-generation photoelectric devices. However, the development of perovskite QDs-based multifunctional materials still needs to be addressed in order to further advance the application of perovskite QDs. Herein, a successful synthesis of Janus microfibers array Janus membrane (JMAJM) with up-down structure and multifunction of luminescence, magnetism and electroconductivity is firstly achieved based on CsPbBr QDs through a parallel electrospinning.

Novel green/red oxyfluoride phosphors with excellent optical properties for near-UV excited white light emitting diode.

Novel eye-sensitive BaNbOF(HO):Tb green and BaNbOF(HO):Mn red oxyfluoride phosphors with extremely strong absorption in the UV region were designed and synthesized by simple co-precipitation strategy. Particularly, Tb ions were doped in this matrix for the first time, which greatly improves their absorption efficiency in the near ultraviolet region (367 nm) and emits sharp green light (544 nm). In addition, the BaNbOF(HO):Mn red phosphors have strong zero phonon line (ZPL) emission at 625 nm, which is conducive to improving the sensitivity of human eye and color purity.

Dual-Confinement Effect of Nanocages@Nanotubes Suppresses Polysulfide Shuttle Effect for High-Performance Lithium-Sulfur Batteries.

The shuttle effect of lithium polysulfides (LiPSs) severely hinders the development and commercialization of lithium-sulfur batteries, and the design of high-conductive carbon fiber-host material has become a key solution to suppress the shuttle effect. In this work, a unique Co/CoN-carbon nanocages@TiO-carbon nanotubes structure (NC@TiO-CNTs) is constructed using an electrospinning and nitriding process. Lithium-sulfur batteries using NC@TiO-CNTs as cathode host materials exhibit high sulfur utilization (1527 mAh g at 0.

Facilely Direct Construction, White-Light Emission, and Color-Adjustable Luminescence of LaF :Pr @SiO Yolk-Shell Nanospheres with Moisture Resistance.

Poor water stability and single luminous color are the major drawbacks of the most phosphors reported. Therefore, it is important to realize multicolor luminescence in a phosphor with single host and single activator as well as moisture resistance. LaF :Pr @SiO yolk-shell nanospheres are facilely obtained by a designing new technology of a simple and cost-effective electrospray ionization combined with a dicrucible fluorating technique without using protective gas.

Government crisis communication innovation and its psychological intervention coupling: Based on an analysis of China's provincial COVID-19 outbreak updates.

Outbreak updates are an integral part of crisis communication during epidemics. Regarding the COVID-19 crisis communication, localities in China present different strategies for managing outbreak updates, which largely determine the effect of crisis communication and the evolution of social psychology. Depending on the analysis of the update texts from 31 provincial (autonomous regions and municipalities directly under the central government) health committees in China, the study found the differences among the provincial outbreak updates and summarizes 12 innovative crisis communication ways.

The piRNA pathway is required for nucleopolyhedrovirus replication in Lepidoptera.

The Piwi-interacting RNA (piRNA) pathway has been shown to be involved in the antiviral defense against RNA viruses, especially in mosquitoes, but its universality has been questioned. Here, we used the Bombyx mori nucleopolyhedrovirus (BmNPV) -infected silkworm as a model to explore the effects of the key factors of piRNA pathway, BmAgo3 and Siwi, on replication of a large DNA virus (belonging to the family of Baculoviridae). We demonstrated that BmAgo3 and Siwi could promote the replication of BmNPV through both overexpression and knockdown experiments in BmN cell lines and silkworm larvae.

Pseudo-tricolor typed nanobelts and arrays simultaneously endowed with conductive anisotropy, magnetism and white fluorescence.

A novel [uniaxial needle]//[coaxial needle]//[uniaxial needle] parallel spinneret is first innovatively designed and manufactured by inserting a coaxial needle into the middle of a bi-axial parallel needle, and the corresponding spinning device is established. With the aid of the distinctive-structured spinneret and the spinning device, a novel and brand-new flexible one-dimensional nanobelt//coaxial nanobelt//nanobelt tri-strand parallel nanobelt, very much like a tricolor flag and named a pseudo-tricolor typed nanobelt, is successfully prepared by electrospinning technology for the first time. Microscopically, partition of four independent domains in the pseudo-tricolor typed nanobelt is realized, and such a partitioned structure can assemble various functions and helps reduce detrimental interactions among various functions to acquire excellent poly-functions of multifunctional nanomaterials.

Tri-functional aerogel photocatalyst with an S-scheme heterojunction for the efficient removal of dyes and antibiotic and hydrogen generation.

A novel three-dimensional (3D) S-scheme S-gCN/TiO/SiO/PAN aerogel heterojunction photocatalyst (denoted as S-gTAHP) is rationally devised and manufactured by combining electrospinning, calcination, hydrothermal and freeze-drying techniques. The synthesized S-gCN molecule is different from traditional g-CN, which has a small molecular structure similar to melamine. S-gCN is embedded in the interwoven network structure of TiO/PAN short fibers, and the catalytic system of the S-scheme heterojunction is formed with SiO as a crosslinking agent.

Distinctive Sandwich-Type Composite Film and Deuterogenic Three-Dimensional Triwall Tubes Affording Concurrent Aeolotropic Conduction, Magnetism, and Up-/Down-Conversion Luminescence.

Compared to single functional materials, multifunctional materials with electrical conduction, magnetism, and luminescence are more attractive and promising, so it has become an important subject. A distinctive sandwich-type composite film (STCF) with dual-color up- and down-conversion luminescence, magnetism, and aeolotropic conduction is prepared by layer-by-layer electrospinning technology. Macroscopically, STCF is assembled by three tightly bonded layers, including a [polypyrrole (PPy)/poly(methyl methacrylate) (PMMA)]//[NaYF:Yb, Er/PMMA] Janus nanobelt array layer as the first layer, a CoFeO/polyacrylonitrile (PAN) nanofiber nonarray layer as the second layer, and a NaGeF:Mn/polyvinylpyrrolidone (PVP) nanofiber nonarray layer as the third layer.

"Off-On" typed upconversion fluorescence resonance energy transfer probe for the determination of Cu in tap water.

Detection of copper plays a prominent role in the environmental protection and human health. Herein, we firstly design and construct an "off-on" upconversion fluorescence resonance energy transfer (UFRET) probe with low toxicity for the Cu determination by using NaYF: Yb, Er upconversion nanoparticles (UCNPs) and Au NPs. UCNPs with positive charge and Au NPs with negative charge are respectively employed as the donor and acceptor, and bound together to form UFRET probe.

Two steps synthesis of plum-shaped C@Ni/MnO nanofiber heterostructures for trapping and catalyzing polysulfides in lithium-sulfur batteries.

Both spherical MnO as adsorbent and Ni nanoparticles as catalyzer, with highly exposed contact surface area in the carbon nanofibers, are successfully synthesized via electrospinning technology combined with carbothermal reduction. Compared with typical electrospun carbon nanofiber composites, the as-prepared C@Ni/MnO composite fibers as interlayer enable MnO and Ni to contact fully with polysulfides rather than provide local contact surface. With the sulfur loading of 1.

A fluorescent triboelectric nanogenerator manufactured with a flexible janus nanobelt array concurrently acting as a charge-generating layer and charge-trapping layer.

Triboelectric nanogenerators (TENGs) have opened a new direction in the field of flexible devices. Here, a fluorescent TENG-JNA constructed with a flexible Janus nanobelt array (JNA) and PVDF/PVP nanofibers membrane by electro-spinning is reported for the first time. The building unit of JNA is the [PANI/CNTs/PMMA]//[Tb(BA)phen/PMMA] Janus nanobelts, which demonstrate green fluorescence and electrical conduction bi-function, where two independent partitions are microscopically realized in the Janus nanobelts.

Simultaneous Visual Detection and Removal of Cu with Electrospun Self-Supporting Flexible Amidated Polyacrylonitrile/Branched Polyethyleneimine Nanofiber Membranes.

Sensitive detection and effective removal of copper ions (Cu) from water are still arduous tasks required to protect public health and environmental safety because of the serious impacts of Cu on humans and other organisms. Herein, we report the design and fabrication of self-supporting flexible amidated polyacrylonitrile/branched polyethyleneimine nanofiber membranes (abbreviated as aPAN/BPEI NMs) facile electrospinning and a subsequent hydrothermal method, which are used not only as strips for the visual detection of Cu but also as effective adsorbents for the removal of Cu from water. Because aPAN/BPEI NMs are self-supporting, they can be easily removed from the solution to reduce secondary pollution to the environment.

Discovery of IDO1 inhibitors containing a decahydroquinoline, decahydro-1,6-naphthyridine, or octahydro-1H-pyrrolo[3,2-c]pyridine scaffold.

A series of IDO1 inhibitors containing a decahydroquinoline, decahydro-1,6-naphthyridine, or octahydro-1H-pyrrolo[3,2-c]pyridine scaffold were identified with good cellular and human whole blood activity against IDO1. These inhibitors contain multiple chiral centers and all diastereomers were separated. The absolute stereochemistry of each isomers were not determined.

SAR towards indoline and 3-azaindoline classes of IDO1 inhibitors.

A novel series of IDO1 inhibitors have been identified with good IDO1 Hela cell and human whole blood activity. These inhibitors contain an indoline or a 3-azaindoline scaffold. Their structure-activity-relationship studies have been explored.

Novel photosensitive dual-anisotropic conductive Janus film endued with magnetic-luminescent properties and derivative 3D structures.

A new photosensitive dual-anisotropic conductive Janus film (PDCJF) is proposed for the first time. It is rationally designed and manufactured by facile electrospinning. PDCJF is firstly constructed using 2,7-dibromo-9-fluorenone (DBF) with photoconductive and luminescent properties.

Discovery of macrocyclic HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.

A series of unique macrocyclic HDACs 1, 2, and 3 selective inhibitors were identified with good enzymatic activity and high selectivity over HDACs 6 and 8. These macrocyclic HDAC inhibitors used an ethyl ketone as the zinc-binding group. Compounds 25 and 26 stood out as leads due to their low double-digit nM ECs in the 2C4 cell-based HIV latency reactivation assay.

Discovery of Ethyl Ketone-Based Highly Selective HDACs 1, 2, 3 Inhibitors for HIV Latency Reactivation with Minimum Cellular Potency Serum Shift and Reduced hERG Activity.

We describe the discovery of histone deacetylase (HDACs) 1, 2, and 3 inhibitors with ethyl ketone as the zinc-binding group. These HDACs 1, 2, and 3 inhibitors have good enzymatic and cellular activity. Their serum shift in cellular potency has been minimized, and selectivity against hERG has been improved.

Mild Condition for the Deoxygenation of α-Heteroaryl-Substituted Methanol Derivatives.

A mild condition via PPh/I/imidazole for the deoxygenation of substituted methanol derivatives has been identified. This metal-free process was found to proceed well on secondary or tertiary alcohols substituted with one or two heteroaryl groups, and it tolerates acid-sensitive heterocycles. This condition works for methanol derivatives substituted with 2-pyridyl, 4-pyridyl, or other heterocyclic groups, allowing the negative charge formed during the reaction to resonate to a nitrogen atom.