FNDC4 alleviates cardiac ischemia/reperfusion injury through facilitating HIF1α-dependent cardiomyocyte survival and angiogenesis in male mice.

Fibronectin type III domain-containing (FNDC) proteins play critical roles in cellular homeostasis and cardiac injury, and our recent findings define FNDC5 as a promising cardioprotectant against doxorubicin- and aging-related cardiac injury. FNDC4 displays a high homology with FNDC5; however, its role and mechanism in cardiac ischemia/reperfusion (I/R) injury remain elusive. Here, we show that cardiac and plasma FNDC4 levels are elevated during I/R injury in a hypoxia-inducible factor 1α (HIF1α)-dependent manner.

Metrnl: a promising biomarker and therapeutic target for cardiovascular and metabolic diseases.

Modern human society is burdened with the pandemic of cardiovascular and metabolic diseases. Metrnl is a widely distributed secreted protein in the body, involved in regulating glucose and lipid metabolism and maintaining cardiovascular system homeostasis. In this review, we present the predictive and therapeutic roles of Metrnl in various cardiovascular and metabolic diseases, including atherosclerosis, ischemic heart disease, cardiac remodeling, heart failure, hypertension, chemotherapy-induced myocardial injury, diabetes mellitus, and obesity.

Significance of serum sestrin2 as a biomarker of severity and functional outcome in acute intracerebral hemorrhage: a prospective observational longitudinal study.

Background: Sestrin2 is a highly conserved stress-inducible protein with neuroprotective properties. Herein, we investigated the prognostic significance of serum sestrin2 in human intracerebral hemorrhage (ICH).

Methods: In this prospective observational longitudinal study, we enrolled 126 patients with supratentorial ICH as cases together with 126 healthy individuals as controls.

A nitrogen-doped carbon nanotube confined CuCo nanoalloy catalyzing one-pot conversion of levulinic acid to 1,4-pentanediol.

Nitrogen-doped carbon nanotube confined CuCo nanoalloy catalysts are fabricated by using ZIF-67 as a sacrificial template for the one-pot selective hydrogenation of levulinic acid (LA) to 1,4-pentanediol (1,4-PDO). The optimal catalyst achieves a high 1,4-PDO yield of 87.8% at full LA conversion.

The Value of CD64 in the Early Diagnosis for Intracranial Infection After Craniocerebral Surgery.

Purpose: To investigate the value of CD64 in the early diagnosis of intracranial infection after craniocerebral surgery.

Methods: A total of 93 patients who met the inclusion and exclusion criteria after neurosurgery in Lianyungang First People's Hospital and Lianyungang Second People's Hospital were admitted and divided into experimental group with intracranial infection (n = 32) and uninfected control group (n = 61) according to the results of cerebrospinal fluid culture. We performed relevant statistical analysis, drew the receiver operating characteristic curve and calculated area under the curve (AUC).

Conversion of cellulose into levulinic acid under the catalysis of Brønsted acidic ionic liquid and erbium chloride in water.

We propose a new approach for the synergistically catalytic conversion of cellulose to levulinic acid (LA) in water by SOH-functionalized ionic liquid (SFIL) and lanthanide chloride (LnCl). Compared with using 1-methyl-3-(3-sulfopropyl)imidazolium chloride ([MIMPS]Cl) only, the LA yield using [MIMPS]Cl and ErCl increased by 14.4% and 13.

Etiology Analysis and Diagnosis and Treatment Strategy of Traumatic Brain Injury Complicated With Hyponatremia.

Objective: To explore the etiology and diagnosis and treatment strategy of traumatic brain injury complicated with hyponatremia.

Methods: 90 patients with traumatic brain injury admitted to our hospital from December 2019 to December 2020 were retrospectively analyzed and divided into hyponatremic group (50 patients) and non-hyponatremic group (40 patients) according to the patients' concomitant hyponatremia, and the clinical data of the two groups were collected and compared. In addition, patients in the hyponatremia group were divided into a control group and an experimental group of 25 patients each according to their order of admission, with the control group receiving conventional treatment and the experimental group using continuous renal replacement therapy (CRRT).

CO-Releasing Materials: An Emphasis on Therapeutic Implications, as Release and Subsequent Cytotoxicity Are the Part of Therapy.

The CO-releasing materials (CORMats) are used as substances for producing CO molecules for therapeutic purposes. Carbon monoxide (CO) imparts toxic effects to biological organisms at higher concentration. If this characteristic is utilized in a controlled manner, it can act as a cell-signaling agent for important pathological and pharmacokinetic functions; hence offering many new applications and treatments.

Catalytic dehydration of fructose to 5-hydroxymethylfurfural over Nb2O5 catalyst in organic solvent.

The catalytic dehydration of fructose to 5-hydroxymethylfurfural (HMF) in DMSO was performed over Nb2O5 derived from calcination of niobic acid at various temperatures (300-700 °C). The catalysts were characterized by powder X-ray diffraction, N2 physical adsorption, temperature-programed desorption of NH3, n-butylamine titration using Hammett indicators, infrared spectroscopy of adsorbed pyridine, and X-ray photoelectron spectroscopy. It was found that both catalytic activity and surface acid sites decrease with increasing calcination temperatures.

Dehydration of fructose to 5-hydroxymethylfurfural by rare earth metal trifluoromethanesulfonates in organic solvents.

The catalytic dehydration of fructose to 5-hydroxymethylfurfural (HMF) was investigated by using various rare earth metal trifluoromethanesulfonates, that is, Yb(OTf)(3), Sc(OTf)(3), Ho(OTf)(3), Sm(OTf)(3), Nd(OTf)(3) as catalysts in DMSO. It is found that the catalytic activity increases with decreasing ionic radius of rare earth metal cations. Among the examined catalysts, Sc(OTf)(3) exhibits the highest catalytic activity.

Synthesis of ZrO2 nanowires by ionic-liquid route.

Zirconia precursor nanowires were synthesized via the solvothermal reaction of zirconium tetra-n-propoxide Zr(OPr(n))(4) with ethylene glycol and 1-butyl-3-methyl imidazolium tetrafluoroborate ionic liquid at 160 degrees C. The as-synthesized nanowires were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), powder X-ray diffraction (XRD), thermogravimetric and differential scanning calorimetric (TG-DSC) analysis, and infrared spectroscopy (IR), etc. The length of the as-synthesized nanowires reaches approximately 20 mum, and the width approximately 50 nm, giving an aspect ratio of a few hundreds.

In situ source-template-interface reaction route to hollow ZrO(2) microspheres with mesoporous shells.

Hollow ZrO(2) microspheres with mesoporous shells have been synthesized by a novel hydrothermal reaction of zirconium oxychloride in the presence of urea, hydrochloric acid, and ethanol. The morphology and shell thickness of the hollow microspheres can be controlled by varying synthesis conditions. After calcination at high temperature, the morphologies of the hollow microspheres are essentially preserved.

Novel ionic liquid assisted synthesis of SnO2 microspheres.

Tin oxide (SnO2) microspheres with an average 2.5 microm in diameters have been successfully synthesized through a rapid hydrothermal process heating by microwave in the presence of an ionic liquid 1-butyl-3-methyl imidazolium tetrafluoroborate. X-ray diffraction, scanning electron microscopy and transmission electron microscopy are used to characterize the morphology and crystalline structure of the microspheres.