Publications by authors named "Wenruo Yao"
Article Synopsis
- IL-17C plays a significant role in neutrophilic asthma, showing increased levels in both asthmatic patients and OVA/CFA-induced asthma models.
- Experiments using both Il-17c-deficient mice and those treated with IL-17C revealed that IL-17C exacerbates inflammation by promoting M1 macrophage differentiation while inhibiting M2 macrophages.
- Targeting the IL-17C/IL-17RE signaling pathway may provide new therapeutic opportunities for treating neutrophilic asthma.
Introduction: Opportunistic pathogen infection is one of the important inducements for asthma exacerbation. Pseudomonas aeruginosa (PA) is a kind of dominant pathogenic bacteria in the respiratory tract that is associated with severe asthma, but the underlying mechanisms still remains unclear.
Objectives: To examine the role of PA infection in the bias of the inflammatory endotype in asthma and its effect on the sensitivity to steroid therapy.