Preparation of a novel 3D printed grinding wheel with linear cooling channels and study on the grinding performance.

In this study, a novel type of diamond grinding wheel with linear cooling channels (GWLCC) is proposed, and an innovative manufacturing process is employed to develop this new grinding wheel. Grinding experiments conducted on four types of hard and brittle materials demonstrate that the grinding performance of GWLCC is better than that of conventional dense grinding wheels. Furthermore, the grinding performance of GWLCC was further investigated by comparing the abrasive ratio and working current under various grinding process parameters.

Targeting PHB2-mediated mitophagy alleviates nonesterified fatty acid-induced mitochondrial dysfunction in bovine mammary epithelial cells.

Mitochondrial dysfunction has been reported to occur in the mammary gland of dairy cows suffering from ketosis. Prohibitin 2 (PHB2) plays a crucial role in regulating mitophagy, which clears impaired mitochondria to maintain normal mitochondrial function. Therefore, the current study aimed to investigate how PHB2 mediates mitophagy, thereby influencing mitochondrial function in the immortalized bovine mammary epithelial cell line (MAC-T cells).

Inositol-requiring enzyme 1α and c-Jun N-terminal kinase axis activation contributes to intracellular lipid accumulation in calf hepatocytes.

During the perinatal period, dairy cows undergo negative energy balance, resulting in elevated circulating levels of nonesterified fatty acids (NEFA). Although increased blood NEFA concentrations are a physiological adaptation of early lactation, excessive NEFA in dairy cows is a major cause of fatty liver. Aberrant lipid metabolism leads to hepatic lipid accumulation and subsequently the development of fatty liver.

Composite control of anti-drone platform for stable tracking under disturbance.

First, focused on the complex problem that a U-shaped tracking frame is unreachable to obtain the pointing angles of an unmanned aerial vehicle target, a novel coordinate transformation method is proposed in this paper. The fixed transformation relationship between the intermediate links is deduced by establishing a unified coordinate system, simplifying the algorithm conversion process, and saving computing resources and time. Furthermore, the accuracy of the proposed method has been verified in both aspects of theory and experiment.

OX40L-Armed Oncolytic Virus Boosts T-cell Response and Remodels Tumor Microenvironment for Pancreatic Cancer Treatment.

The resistance of pancreatic ductal adenocarcinoma (PDAC) to immunotherapies is caused by the immunosuppressive tumor microenvironment (TME) and dense extracellular matrix. Currently, the efficacy of an isolated strategy targeting stromal desmoplasia or immune cells has been met with limited success in the treatment of pancreatic cancer. Oncolytic virus (OV) therapy can remodel the TME and damage tumor cells either by directly killing them or by enhancing the anti-tumor immune response, which holds promise for the treatment of PDAC.

Effect of Controlling Light on Cashmere Growth and Harmful Gas Parameters in Shanbei White Cashmere Goats.

The quality and yield of cashmere closely affect the economic benefits of cashmere goat farming. Studies have shown that controlling light can have an important impact on cashmere but can also affect the concentration of harmful gases. In order to explore the impact of a short photoperiod on the growth of cashmere and harmful gases in goat houses, 130 female (non-pregnant) Shanbei white cashmere goats, aged 4-5 years with similar body weights, were randomly divided into a control group and a treatment group, with 65 goats in each group.

Transcriptome Analysis Reveals the Genes Related to Water-Melon Fruit Expansion under Low-Light Stress.

Watermelon is one of people's favorite fruits globally. Fruit size is one of the important characteristics of fruit quality. Low light can seriously affect fruit development, but there have been no reports concerning molecular mechanism analysis in watermelons involved in fruit expansion under low-light stress.

Dietary Nutritional Level Affects Intestinal Microbiota and Health of Goats.

The intestine is a complex micro-ecosystem, and its stability determines the health of animals. Different dietary nutritional levels affect the intestinal microbiota and health. In this study, the nutritional levels of energy and protein in the diet of goats were changed, and the body weight was measured every 15 days.

[Distribution characteristics of 46 elements in drinking water in Ankang area in 2020].

Objective: To understand the distribution characteristics of 46 elements in drinking water in Ankang area of Shanxi Province.

Methods: A total of 46 elements in drinking water samples collected in Ankang area during dry and wet seasons in 2020 were determined by inductively coupled plasma mass spectrometry(ICP-MS). According to the "drinking water hygiene standards"(GB 5749-2022) and "food safety national standards".

A study on the cyclist head kinematic responses in electric-bicycle-to-car accidents using decision-tree model.

Due to the high frequent traffic accidents involving electric bicycles (E-bike), it urgently needs improved protection of cyclists, especially their heads. In this study, by adjusting the initial impact velocities of E-bike and car, initial impact angle between E-bike and car, initial E-bike impact location, and body size of cyclist, 1512 different accident conditions were constructed and simulated using a verified E-bike-to-car impact multi-body model. The cyclist's head kinematic responses including the head relative impact velocity, WAD (Wrap around distance) of head impact location and HIC (15 ms Head Injury Criterion) were collected from simulation results to make up a dataset for data mining.

[Chronic sleep deprivation exacerbates cognitive and pathological impairments in APP/PS1/tau triple transgenic Alzheimer's disease model mice].

Sleep exerts important functions in the regulation of cognition and emotion. Recent studies have found that sleep disorder is one of the important risk factors for Alzheimer's disease (AD), but the effects of chronic sleep deprivation on the cognitive functions of AD model mice and its possible mechanism are still unclear. In the present study, 8-month-old male APP/PS1/tau triple transgenic AD model (3xTg-AD) mice and wild type (WT) mice (n = 8 for each group) were subjected to chronic sleep deprivation by using the modified multiple platform method, with 20 h of sleep deprivation each day for 21 days.

MES7 Modulates Seed Germination via Regulating Salicylic Acid Content in Arabidopsis.

Seed germination is an important phase transitional period of angiosperm plants during which seeds are highly sensitive to different environmental conditions. Although seed germination is under the regulation of salicylic acid (SA) and other hormones, the molecular mechanism underlying these regulations remains mysterious. In this study, we determined the expression of SA methyl esterase () family genes during seed germination.

DEAD-box helicases modulate dicing body formation in .

Eukaryotic cells contain numerous membraneless organelles that are made from liquid droplets of proteins and nucleic acids and that provide spatiotemporal control of various cellular processes. However, the molecular mechanisms underlying the formation and rapid stress-induced alterations of these organelles are relatively uncharacterized. Here, we investigated the roles of DEAD-box helicases in the formation and alteration of membraneless nuclear dicing bodies (D-bodies) in We uncovered that RNA helicase 6 (RH6), RH8, and RH12 are previously unidentified D-body components.

A study on cyclist head injuries based on an electric-bicycle to car accident reconstruction.

Objective: In China, the electric-bicycle (E-bike) has become one of the most common modes of travel. However, the safety of E-bike has not received sufficient attentions, especially in the area of protection of the cyclists' head.

Methods: In this study, an E-bike-to-car accident was reconstructed using MADYMO and LS-DYNA software and head injuries of the cyclist were analyzed.

Genome-wide identification, characterization, and expression analysis of the expansin gene family in watermelon ().

Expansins are plant cell-wall loosening proteins involved in cell enlargement, adaptive responses to environmental stimuli, and various developmental processes. Although expansins have been characterized in many plant species, little is reported on this family in watermelon. In this study, 30 expansin genes in the watermelon genome (ClEXPs) were identified.

AtXRN4 Affects the Turnover of Chosen miRNA*s in .

Small RNA (sRNA) turnover is a key but poorly understood mechanism that determines the homeostasis of sRNAs. Animal XRN genes contribute the degradation of sRNAs, AtXRN2 and AtXRN3 also contribute the pri-miRNA processing and miRNA loop degradation in plants. However, the possible functions of the plant XRN genes in sRNA degradation are far from known.

Robust Radiation Sources Localization Based on the Peak Suppressed Particle Filter for Mixed Multi-Modal Environments.

This paper addresses a detection problem where sparse measurements are utilized to estimate the source parameters in a mixed multi-modal radiation field. As the limitation of dimensional scalability and the unimodal characteristic, most existing algorithms fail to detect the multi-point sources gathered in narrow regions, especially with no prior knowledge about intensity and source number. The proposed Peak Suppressed Particle Filter (PSPF) method utilizes a hybrid scheme of multi-layer particle filter, mean-shift clustering technique and peak suppression correction to solve the major challenges faced by current existing algorithms.

[Evaluation for heavy metal pollution of soil and herb from main producing area of Phellodendron amurense in China].

In order to evaluate the heavy metal potential pollution of soil and medicinal materials in main producing area of Phellodendron amurense, we collected 32 soil samples and 32 herb samples from northeast and north of China covering four provinces. In this study, the detection of heavy metal contents was conducted by ICP emission spectroscopy and atomic fluorescence spectrometry. The results showed that the soil from all areas of Ph amurense generally reached the national standard.

A NAC transcription factor gene of Chickpea (Cicer arietinum), CarNAC3, is involved in drought stress response and various developmental processes.

NAC transcription factors have been found to play important roles in plant development and responses to environmental stresses. Based on two cDNA libraries constructed from the PEG-treated and -nontreated seedling leaves of chickpea, a NAC gene, CarNAC3, was isolated and characterized. The results indicated that CarNAC3 contained 285 amino acids and had a conserved NAC domain.

Comparative analysis of ESTs in response to drought stress in chickpea (C. arietinum L.).

Chickpea (Cicer arietinum L.) is an important pulse crop grown mainly in the arid and semi-arid regions. To identify the water-stress-induced genes, two non-normalized cDNA libraries were constructed from the seedling leaves of a drought-tolerant chickpea cultivar under PEG-treated and -nontreated conditions.