Comprehensive analysis of the clinical and biological significances for chemokine CXCL3 in cholangiocarcinoma.

Cholangiocarcinoma (CHOL) is a race malignant cancer arising from bile duct epithelial cells in clinical practice. C-X-C motif chemokine ligand 3 (CXCL3) is a member of chemokines family, which participates in the pathogenesis of various tumors. However, the association between CXCL3 and CHOL is unclear.

Product Control and Insight into Conversion of C6 Aldose Toward C2, C4 and C6 Alditols in One-Pot Retro-Aldol Condensation and Hydrogenation Processes.

Alcohols have a wide range of applicability, and their functions vary with the carbon numbers. C6 and C4 alditols are alternative of sweetener, as well as significant pharmaceutical and chemical intermediates, which are mainly obtained through the fermentation of microorganism currently. Similarly, as a bulk chemical, C2 alditol plays a decisive role in chemical synthesis.

Direct conversion of C6 sugars to methyl glycerate and glycolate in methanol.

The present work deals with the one-pot conversion of C6 sugars to methyl glycerate and glycolate a cascade of retro-aldol condensation and oxidation processes catalyzed by using MoO as the Lewis acid catalyst and Au/TiO as the oxidation catalyst in methanol. Methyl glycerate (MGLY) is the product of C6 ketose (fructose), while methyl glycolate (MG) is produced from C6 aldose (mannose, glucose). It is found that a good one-pot match between two reactive processes is the key to the production of MGLY and MG with high yield (27.