6-Indolo-[2,3-]-quinoxaline derivatives as promising bifunctional SHP1 inhibitors.

Dysfunction in the SHP1 enzyme can cause cancers and many diseases, so it is of great significance to develop novel small molecule SHP1 inhibitors. Through continuous monitoring of metabolic and targeted processes of SHP1 inhibitors in real-time, we can evaluate the effectiveness and toxicity of the inhibitors, further optimize drug design, and explore SHP1 biology. Indoloquinoxaline is an important class of N-containing heterocycle, which has been studied and applied in the pharmacological field and in optoelectronic materials.

Unveiling drastic influence of cross-interactions in hydrothermal carbonization of spirulina with cellulose, lignin or poplar on nature of hydrochar and activated carbon.

Spirulina platensis contains abundant nitrogen-containing organics, which might react with derivatives of cellulose/lignin during hydrothermal carbonization (HTC), probably affecting yield, property of hydrochar, and pore development in activation of hydrochar. This was investigated herein by conducting co-HTC of spirulina platensis with cellulose, lignin, and sawdust at 260 °C and subsequent activation of the resulting hydrochars with KCO at 800 °C. The results showed that cross-condensation of spirulina platensis-derived proteins with cellulose/lignin-derived ketones and phenolics did take place in the co-HTC, forming more π-conjugated heavier organics, retaining more nitrogen species in hydrochar, reducing yields of hydrochar, making the hydrochar more aromatic and increasing the thermal stability and resistivity towards activation.

Impact of iron-modified biochars on soil nitrous oxide emissions: Variations with iron salts and soil fertility.

Nitrous oxide (NO) emissions from soils are a significant environmental concern due to their contribution to greenhouse gas emissions. Biochar has been considered as a promising soil amendment for its potential to influence soil processes. Iron modification of biochar has been extensively discussed for its ability to enhance adsorption of pollutants, yet its impact on mitigating soil NO emissions remains poorly understood.

Carbon-based single-atom catalysts in advanced oxidation reactions for water remediation: From materials to reaction pathways.

Single-atom catalysts (SACs) have been widely recognized as state-of-the-art catalysts in environment remediation because of their exceptional performance, 100% metal atomic utilization, almost no secondary pollution, and robust structures. Most recently, the activation of persulfate with carbon-based SACs in advanced oxidation processes (AOPs) raises tremendous interest in the degradation of emerging contaminants in wastewater, owning to its efficient and versatile reactive oxidant species (ROS) generation. However, the comprehensive and critical review unraveling the underlying relationship between structures of carbon-based SACs and the corresponding generated ROS is still rare.

A Review on N-Doped Biochar for Oxidative Degradation of Organic Contaminants in Wastewater by Persulfate Activation.

The Persulfate-based advanced oxidation process is the most efficient and commonly used technology to remove organic contaminants in wastewater. Due to the large surface area, unique electronic properties, abundant N functional groups, cost-effectiveness, and environmental friendliness, N-doped biochars (NBCs) are widely used as catalysts for persulfate activation. This review focuses on the NBC for oxidative degradation of organics-contaminated wastewater.

Catalytic hydrogenolysis of lignin to phenolic monomers over Ru supported N,S-co-doped biochar: The importance of doping atmosphere.

Doping of heteroatoms into carbon materials is a popular method to modify their physicochemical structures and has been widely used in the fields of energy conversion and storage. This study aims to investigate the effect of doping atmosphere on the catalytic performance of nitrogen and sulfur co-doped biochar supported Ru in the production of phenolic monomers from lignin hydrogenolysis. The results showed that the catalyst prepared under CO atmosphere (Ru@CNS-CO) was able to produce phenolic monomers from corncob lignin with a yield up to 36.

Production of methyl levulinate from cellulose over cobalt disulfide: The importance of the crystal facet (111).

The conversion of cellulose to platform chemicals has attracted much attention because of its renewability. This work proposed an earth-abundant cobalt disulfide as a heterogeneous catalyst for methyl levulinate production from cellulose. The highest yield of methyl levulinate reached 61 mol% under the tested conditions of 200 °C, 2 MPa initial pressure, 0.

Application of Biochar Derived From Pyrolysis of Waste Fiberboard on Tetracycline Adsorption in Aqueous Solution.

In this study, biochars derived from waste fiberboard biomass were applied in tetracycline (TC) removal in aqueous solution. Biochar samples were prepared by slow pyrolysis at 300, 500, and 800°C, and were characterized by ultimate analysis, Fourier transform infrared (FTIR), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), Brunauer-Emmett-Teller (BET), etc. The effects of ionic strength (0-1.

Luminescent composite polymer fibers: in situ synthesis of silver nanoclusters in electrospun polymer fibers and application.

The purpose of this study is to prepare multifunctional polymer fibers. We report a simple and controllable method for in situ synthesis of Ag nanoclusters (NCs) in electrospun polymer fibers via a photochemical reaction. The prepared composite polymer fibers emit pink luminescence and the luminescence property can be optimized by pH and Ag(I) precursor concentration.

Fluorescent Ag nanoclusters templated by carboxymethyl-β-cyclodextrin (CM-β-CD) and their in vitro antimicrobial activity.

A green and environment-friendly method for synthesis of water-soluble and fluorescent Ag nanoclusters was developed using carboxymethyl-β-cyclodextrin (CM-β-CD) as both reducing and stabilizing reagent. The optical properties of Ag nanoclusters were characterized using the photoluminescence, ultraviolet-visible absorption, and laser desorption time of flight mass spectroscopies. The role of carboxylic groups was discussed in the photoactivated synthesis of Ag nanoclusters.