Publications by authors named "Wenqiu Xu"
Article Synopsis
- - Preeclampsia (PE) is a serious pregnancy complication characterized by high blood pressure and protein in urine after 20 weeks of gestation, and the study aimed to validate the use of maternal plasma cell-free DNA (cfDNA) profiles alongside clinical risk factors to predict early and late-onset PE.
- - The research involved analyzing NIPT data from 2,727 pregnant women in China, categorizing samples into 143 early-onset, 580 late-onset PE cases, and 2,004 healthy controls to identify predictive markers using statistical methods and machine learning.
- - The findings revealed that distinct patterns in cfDNA coverages, along with maternal health information, could effectively predict the risk of PE
Noninvasive preeclampsia prediction using plasma cell-free RNA signatures.
Am J Obstet Gynecol
November 2023
Background: Preeclampsia, especially preterm preeclampsia and early-onset preeclampsia, is a life-threating pregnancy disorder, and the heterogeneity and complexity of preeclampsia make it difficult to predict risk and to develop treatments. Plasma cell-free RNA carries unique information from human tissue and may be useful for noninvasive monitoring of maternal, placental, and fetal dynamics during pregnancy.
Objective: This study aimed to investigate various RNA biotypes associated with preeclampsia in plasma and to develop classifiers to predict preterm preeclampsia and early-onset preeclampsia before diagnosis.