Integrated Analysis of Transcriptomics and Proteomics Provides Insights into the Accumulation Mechanism of Ascorbic Acid in Tratt.

Tratt (RRT) is widely cultivated in Guizhou Province, China. In recent years, RRT has emerged as one of the most promising new fruit crops in China, primarily because of its remarkably high levels of ascorbic acid (AsA). In this research, we assessed the AsA levels in RRT across various growth phases.

Leguminous proteins as beneficial baking emulsifiers: A comparative study with traditional sucrose ester.

In recent years, pursuing healthier and more sustainable food ingredients has increased interest in plant-based alternatives to traditional synthetic emulsifiers. In this study, the properties of five legume proteins: soybean protein isolate (SPI), pea protein isolate (PPI), black bean protein isolate (BBPI), white Canavalia protein isolate (WCAI), and white kidney bean protein isolate (WKBPI) were compared with that of the conventional emulsifier sucrose ester (SE), and add them as emulsifiers to the cake making process. The centrifugal instability index of SPI stabilized emulsion (0.

Discovery of viruses and bacteria associated with swine respiratory disease on farms at a nationwide scale in China using metatranscriptomic and metagenomic sequencing.

Respiratory disease (RD) is a worldwide leading threat to the pig industry, but there is still limited understanding of the pathogens associated with swine RD. In this study, we conducted a nationwide genomic surveillance on identifying viruses, bacteria, and antimicrobial resistance genes (ARGs) from the lungs of pigs with RD in China. By performing metatranscriptomic sequencing combined with metagenomic sequencing, we identified 21 viral species belonging to 12 viral families.

Roles of gut microbiome-associated metabolites in pulmonary fibrosis by integrated analysis.

Lung diseases often coincide with imbalances in gut microbiota, but the role of gut microbiota in pulmonary fibrosis (PF) remains unclear. This study investigates the impact of gut microbiota and their metabolites on PF. Serum and lung tissues of normal, bleomycin (BLM)- and silica-induced mice showed significant differences in gut microbiota.

Mathematical Expression and Prediction of VOCs Adsorption Capacity and Isotherm.

Adsorption capacity prediction, which needs to be based on the precise structure-capacity relationship, is important for better adsorbent design. However, the precise adsorption contribution coefficients of pores of different sizes for volatile organic compound (VOC) adsorption remain unclear. Herein, a control variable method is employed as a generative model to realize the numerization of the precise structure-capacity relationship.

Ring-Enhancement on CEUS: Is it Useful in the Differential Diagnosis of Solid Thyroid Nodules?

To investigate the efficiency of contrast-enhanced ultrasound (CEUS) features, particularly ring-enhancement patterns, in the differential diagnosis of thyroid nodules. 302 nodules with CEUS ring-enhancement were retrospectively enrolled, including 135 benign and 167 malignant ones. The ring-enhancement patterns were classified into regular and irregular hyper- or hypo-ring enhancement.

Metarhizium spp. encode an ochratoxin cluster and a high efficiency ochratoxin-degrading amidohydrolase revealed by genomic analysis.

Introduction: Ochratoxins (OTs) are worldwide regulated mycotoxins contaminating a variety of food-environment and agro-environment. Several Aspergillus and Pencillium species synthesize OTs from a six-gene biosynthetic gene cluster (BGC) to produce the highly toxic final product OTA. Although many studies on OTA-degrading enzymes were performed, high efficiency enzymes with strong stability are extremely needed, and the OTA degrading mechanism is poorly understood.

What Chinese Women Seek in Mental Health Apps: Insights from Analyzing User Posts during the COVID-19 Pandemic.

Gender disparity poses a prominent obstacle to achieving effective mental health outcomes in digital healthcare. Despite women being more inclined to use mental health apps and seeking designs tailored to their specific needs, there is limited research on the factors influencing female users' engagement with these apps. The COVID-19 pandemic has further exacerbated its disproportionate impact on women's mental health.

Needle-scalpel therapy inhibits the apoptosis of nucleus pulposus cells via the SDF-1/CXCR4 axis in a rat degenerative cervical intervertebral disc model.

As a common disease, cervical spondylosis (CS) results from the degeneration of the cervical intervertebral disc. However, there are still no effective clinical strategies for the treatment of this disease. Needle-scalpel (Ns), a therapy guided by traditional Chinese medicine theory, alleviates intervertebral disc degradation and is widely used in the clinic to treat CS.

Establishment and application of a quadruplex real-time RT-qPCR assay for differentiation of TGEV, PEDV, PDCoV, and PoRVA.

Porcine viral diarrhea is a common ailment in clinical settings, causing significant economic losses to the swine industry. Notable culprits behind porcine viral diarrhea encompass transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), and porcine rotavirus-A (PoRVA). Co-infections involving the viruses are a common occurrence in clinical settings, thereby amplifying the complexities associated with differential diagnosis.

Fecal PCR survey and genome analysis of in China.

Proliferative enteropathy caused by is an important economic associated disease to pig industry, but the knowledge about the prevalence of in pig farms in China is limited. In addition, there is no complete genome sequence available for isolates from China. In this study, we developed a TaqMan qPCR for the screening of by targeting the bacterial 16S rDNA gene.

Treatment response assessment to chemotherapy with bevacizumab for colorectal liver metastasis by contrast-enhanced ultrasound.

Background: Though contrast-enhanced ultrasound (CEUS) perfusion parameters have been approved to be potential indicators for response to chemotherapy in solid tumors, their ability in assessment of colorectal liver metastasis (CRLM) to chemotherapy with bevacizumab (Bev) has rarely been investigated.

Methods: From March 2021 to May 2022, 115 consecutive CRLM patients with CEUS pre- and post-2 months' chemotherapy with Bev were prospectively enrolled. One target lesion per patient underwent CEUS quantitative analysis with SonoLiver software.

A Metamodel-Based Multi-Scale Reliability Analysis of FRP Truss Structures under Hybrid Uncertainties.

This study introduces a Radial Basis Function-Genetic Algorithm-Back Propagation-Importance Sampling (RBF-GA-BP-IS) algorithm for the multi-scale reliability analysis of Fiber-Reinforced Polymer (FRP) composite structures. The proposed method integrates the computationally powerful RBF neural network with GA, BP neural network and IS to efficiently calculate inner and outer optimization problems for reliability analysis with hybrid random and interval uncertainties. The investigation profoundly delves into incorporating both random and interval parameters in the reliability appraisal of FRP constructs, ensuring fluctuating parameters within designated boundaries are meticulously accounted for, thus augmenting analytic exactness.

Population ageing and sustainability of healthcare financing in China.

Background: In China, the healthcare financing structure involves multiple parties, including the government, society and individuals. Medicare Fund is an important way for the Government and society to reduce the burden of individual medical costs. However, with the aging of the population, the demand of Medicare Fund is increasing.

Gli1 marks a sentinel muscle stem cell population for muscle regeneration.

Adult skeletal muscle regeneration is mainly driven by muscle stem cells (MuSCs), which are highly heterogeneous. Although recent studies have started to characterize the heterogeneity of MuSCs, whether a subset of cells with distinct exists within MuSCs remains unanswered. Here, we find that a population of MuSCs, marked by Gli1 expression, is required for muscle regeneration.

The application and progress of tissue engineering and biomaterial scaffolds for total auricular reconstruction in microtia.

Microtia is a congenital deformity of the ear with an incidence of about 0.8-4.2 per 10,000 births.

Assessment of different factors on the influence of glass wool concentration for detection of main swine viruses in water samples.

Viruses existed in wastewaters might pose a biosecurity risk to human and animal health. However, it is generally difficult to detect viruses in wastewater directly as they usually occur in low numbers in water. Therefore, processing large volumes of water to concentrate viruses in a much smaller final volume for detection is necessary.

ALDOB plays a tumor-suppressive role by inhibiting AKT activation in gastric cancer.

Enhanced aerobic glycolysis has been one of the cancer hallmarks. Cancerous cells develop certain alterations during glucose metabolism for supporting their infinite growth requirement and metastasis. Therefore, targeting metabolism, for instance, crucial glycolytic enzymes, will provide a novel therapeutic strategy to treat cancer.

A highly accurate method for forecasting the compressor geometric variable system based on the data-driven method.

To make the puzzle of aero-engines complete, understanding the law of the compressor geometric variable system is a vital part. Modeling all aspects of aero-engines quickly has been a continuous area of research since the advent of artificial intelligence (AI). However, diagnosing or predicting faults is an ancient adage, and it is vital to explore key system forecast research, particularly since traditional forecasting techniques do not account for future information of non-target parameters.

Assessing artificial intelligence enabled liquid-based cytology for triaging HPV-positive women: a population-based cross-sectional study.

Introduction: Cytology-based triaging is commonly used to manage the care of women with positive human papillomavirus (HPV) results, but it suffers from subjectivity and a lack of sensitivity and reproducibility. The diagnostic performance of an artificial intelligence-enabled liquid-based cytology (AI-LBC) triage approach remains unclear. Here, we compared the clinical performance of AI-LBC, human cytologists and HPV16/18 genotyping at triaging HPV-positive women.

A novel fractional discrete grey model with variable weight buffer operator and its applications in renewable energy prediction.

With the continuous depletion of global fossil energy, optimizing the energy structure has become the focus of attention of all countries. With the support of policy and finance, renewable energy occupies an important position in the energy structure of the USA. Being able to predict the trend of renewable energy consumption in advance plays a vital role in economic development and policymaking.

Isolation and identification of ligninolytic bacterium () from buffalo () rumen and its effects on the fermentation quality, nutrient composition, and bacterial community of rape silage.

This study aimed to isolate and identify a ligninolytic bacterium from the rumen of buffalo () and investigate its effects as a silage additive for whole-plant rape. Three lignin-degradation strains were isolated from the buffalo rumen, with AH7-7 being chosen for further experiments. Strain AH7-7, with acid tolerance and a 51.

SakA Regulates Morphological Development, Ochratoxin A Biosynthesis and Pathogenicity of and the Response to Different Environmental Stresses.

Ochratoxin A (OTA), as a common mycotoxin, has seriously harmful effects on agricultural products, livestock and humans. There are reports on the regulation of SakA in the MAPK pathway, which regulates the production of mycotoxins. However, the role of SakA in the regulation of and OTA production is not clear.