Integrating multi-task and cost-sensitive learning for predicting mortality risk of chronic diseases in the elderly using real-world data.

Background And Objective: Real-world data encompass population diversity, enabling insights into chronic disease mortality risk among the elderly. Deep learning excels on large datasets, offering promise for real-world data. However, current models focus on single diseases, neglecting comorbidities prevalent in patients.

Community screening for dementia among older adults in China: a machine learning-based strategy.

Background: Dementia is a leading cause of disability in people older than 65 years worldwide. However, diagnosing dementia in its earliest symptomatic stages remains challenging. This study combined specific questions from the AD8 scale with comprehensive health-related characteristics, and used machine learning (ML) to construct diagnostic models of cognitive impairment (CI).

Associations of Low-density Lipoprotein Cholesterol With All-cause and Cause-specific Mortality in Older Adults in China.

Context: Limited information was available on detailed associations of low-density lipoprotein cholesterol (LDL-C) with all-cause and cause-specific mortality in older adults.

Methods: This prospective cohort study included a representative sample of 211 290 adults aged 65 or older who participated in Shenzhen Healthy Aging Research 2018-2019. The vital status of the participants by December 31, 2021, was determined.

Sociodemographic and lifestyle determinants of multimorbidity among community-dwelling older adults: findings from 346,760 SHARE participants.

Background: This study aimed to investigate the prevalence of multimorbidity and its associated factors among the older population in China to propose policy recommendations for the management of chronic diseases in older adults.

Methods: This study was conducted based on the 2021 Shenzhen Healthy Ageing Research (SHARE), and involved analysis of 346,760 participants aged 65 or older. Multimorbidity is defined as the presence of two or more clinically diagnosed or non self-reported chronic diseases among the eight chronic diseases surveyed in an individual.

Concordance of Non-Alcoholic Fatty Liver Disease and Associated Factors among Older Married Couples in China.

Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases which affects mainly middle-aged and older adults, resulting in a considerable disease burden. Evidence of concordance on NAFLD and lifestyle factors within older married couples in China is limited. This study aimed to evaluate spousal concordance regarding lifestyle factors and NAFLD among older Chinese couples.

Protocol for Shenzhen Ageing Cohort Study (SZ-ageing): a prospective observational cohort study of elderly disability and cognitive impairment.

Introduction: The incidence and prevalence of disability and cognitive impairment, which are age-related, increase as China has become an ageing society. This study aims to establish the Shenzhen Ageing Cohort Study (SZ-ageing) to explore the epidemiological situation, risk factors and biomarkers of disability and cognitive impairment among Chinese elderly individuals.

Methods: About 3000 participants aged 65 years and older are to be recruited from communities in Shenzhen by using a multistage sampling method.

[Prevalence and factors of nonalcoholic fatty liver disease among elderly in Shenzhen City in 2018].

Objective: To analyze the prevalence and influence factors of nonalcoholic fatty liver disease(NAFLD) among elderly in Shenzhen City.

Methods: From January to December in 2018, a convenient sampling method was used to select 121 042 survey subjects from Shenzhen community residents aged 65 years and above through questionnaire survey, physical examination, laboratory biochemical examination and b-ultrasound examination, demographic information, lifestyle, height, weight, waist circumference, blood pressure, fasting blood glucose, blood lipids, past history and liver B ultrasound result were collected. A total of 121 042 of the subjects were selected for the study with complete information.

Long-term exposure to ambient air pollution and serum liver enzymes in older adults: A population-based longitudinal study.

Purpose: To investigate the association of long-term exposure to ambient air pollution with serum liver enzymes in older adults.

Methods: In this longitudinal study, we investigated 318,911 adults aged 65 years or older and assessed their long-term residential exposure to particulate matter with an aerodynamic diameter ≤2.5 µm (PM), particulate matter with an aerodynamic diameter ≤10 µm (PM), sulfur dioxide (SO), nitrogen dioxide (NO), carbon monoxide (CO), and ozone (O).

Anaemia and associated factors among older adults in an urban district in China: a large-scale cross-sectional study.

Objective: Anaemia leads to poor health outcomes in older adults; however, most current research in China has focused on younger adults. This study aimed to investigate the prevalence of anaemia and its associated factors in older adults in an urban district in China.

Design: A cross-sectional study.

Cross-sectional and longitudinal associations of apolipoprotein A1 and B with glycosylated hemoglobin in Chinese adults.

Apolipoproteins exert a key role on glucose metabolism; however, scarce data have examined the relationship between apolipoproteins and glycated haemoglobin (HbA1c) in Chinese adults. This study determined the cross-sectional and longitudinal associations of serum Apolipoprotein A1 (ApoA1), Apolipoprotein B (ApoB) and the ApoB/A1 ratio with HbA1c in Chinese adults. A total of 1448 subjects (584 men and 864 women) aged 54.

Factors associated with treatment and control of hypertension among elderly adults in Shenzhen, China: a large-scale cross-sectional study.

Objective: Hypertension has become the leading cause of death worldwide. Data on hypertension management among Shenzhen elderly are sparse. Our study aims to investigate treated and controlled hypertension in Shenzhen elderly, and identify relevant predictors.

Sarcopenia in heart failure: a systematic review and meta-analysis.

Aims: Sarcopenia has been found to be frequently associated with co-morbidity among patients with heart failure (HF). However, there remain insufficient data to accurately estimate the global prevalence of sarcopenia in HF. Therefore, the purpose of this research was to conduct a systematic review and meta-analysis to estimate the current overall prevalence of sarcopenia in patients with HF.

Prevalence, treatment, control of type 2 diabetes and the risk factors among elderly people in Shenzhen: results from the urban Chinese population.

Background: Type 2 diabetes is regarded as one of the major public health problems worldwide. We aim to investigate the prevalence, treatment, and control rate in the Chinese urban population aged 65 years or older and also identified associated risk factors.

Methods: One hundred twenty-four thousand seven participants aged 65 years old and older were recruited from January 2018 through December 2018 at local community health service centers in Shenzhen.

Association of Serum Uric Acid with Metabolic Syndrome and Its Components: A Cross-Sectional Study in Chinese Coastal Population.

Few studies reported the association between serum uric acid and the prevalence of metabolic syndrome in China's coastal residents. We aimed to examine the association between serum uric acid and the prevalence of metabolic syndrome as well as its components in adults and elderly from Shenzhen (a China's coastal city). We conducted a survey in a community-based household population in Shenzhen, collecting data about 4049 participants aged 20-69 years.

6-Year trends in lipids among adults in Shenzhen, China.

Background: There may be a beneficial effect on lipid levels in Shenzhen in recent years. In this study, we aimed to examine trends in serum lipids in population in Shenzhen between 2009 and 2015.

Methods: We enrolled 2210 adults aged 18-70 years from two independent cross-sectional studies conducted in 2009 and 2015.

[Effect of lifestyle intervention among pre-hypertensive population in Futian District of Shenzhen City from 2013 to 2015].

Objective: To evaluate the effect of lifestyle intervention program among pre-hypertensive adults in Futian District, Shenzhen City.

Methods: A total of 12 communities were selected randomly from Futian District, Shenzhen City between October and November of 2013. A total of 1183 pre-hypertension population was screened and divided into intervention group(834) and control group(349) according to community sources.

Clustering of cardiovascular disease biological risk factors among older adults in Shenzhen City, China: a cross-sectional study.

Objectives: Few studies reported the clustering of cardiovascular disease (CVD) biological risk factors among older adults. The objective of this study was to characterise the clustering of CVD biological risk factors among adults aged 65 or older in Shenzhen city, China.

Design: Cross-sectional study.

Serum lipids and associated factors of dyslipidemia in the adult population in Shenzhen.

Background: Dyslipidemia is one of the most important independent modifiable risk factors for cardiovascular diseases. The objective of this study was to determine the prevalence and risk factors for dyslipidemia in Shenzhen, a special economic zone and large metropolitan area neighboring Hong Kong.

Methods: A cross-sectional survey of 1,995 adults with a mean age of 46.

Levels and risk factors of antimony contamination in human hair from an electronic waste recycling area, Guiyu, China.

The primitive electronic waste (e-waste) recycling has brought a series of environmental pollutants in Guiyu, China. Antimony is one of the important metal contaminants and has aroused the global concerns recently. We aimed to investigate concentrations of antimony in human hair from Guiyu and compared them with those from a control area where no e-waste recycling exists, and assessed the potential risk factors.

Effect of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) on sexual behaviors and reproductive function in male zebrafish (Danio rerio).

Background: Polybrominated diphenyl ethers (PBDEs) are ubiquitous in various environmental matrices and organisms and pose a threat to reproductive systems of organisms. However, few studies have explored the effects of PBDEs on sexual and reproductive behaviors in animals. Here we evaluated the effect of BDE-47 exposure on sexual and reproductive behaviors in zebrafish (Danio rerio).

Associations of neonatal lead, cadmium, chromium and nickel co-exposure with DNA oxidative damage in an electronic waste recycling town.

Objective: This study aimed to evaluate the effects of toxic heavy metal co-exposure on DNA oxidative damage in neonates from a primitive e-waste recycling region, Guiyu town, China.

Methods: Our participants included 201 pregnant women: 126 from Guiyu town and 75 from Jinping district of Shantou city, where no e-waste recycling and dismantling activities existed. Structured interview questionnaires were administered to the pregnant women and umbilical cord blood (UCB) samples were collected after delivery.

Hair mercury concentrations and associated factors in an electronic waste recycling area, Guiyu, China.

Objective: Toxic heavy metals are released to the environment constantly from unregulated electronic waste (e-waste) recycling in Guiyu, China, and thus may contribute to the elevation of mercury (Hg) and other heavy metals levels in human hair. We aimed to investigate concentrations of mercury in hair from Guiyu and potential risk factors and compared them with those from a control area where no e-waste processing occurs.

Methods: A total of 285 human hair samples were collected from three villages (including Beilin, Xianma, and Huamei) of Guiyu (n=205) and the control area, Jinping district of Shantou city (n=80).