A Reaction-Based ESIPT Fluorescent Probe for the Detection of Hg with Large Stokes Shift.

A novel reaction-based fluorescent probe 1 for Hg was designed and synthesized. 1 was almost nonfluoresent due to inhibition of the ESIPT process between hydroxy group and imid carbonyl oxygen by diphenylphosphinothioate group. After reacting with Hg, the fluorescence intensity of 1 exhibited significant enhancement owing to recovery of the ESIPT process via Hg-promoted desulfurization-hydrolysis of the diphenylphosphinothioate moiety and cleavage of the P-O bond.

A mitochondrion-targeted fluorescent probe based on ESIPT phthalimide for the detection of Hg with large Stokes shift.

A novel mitochondrion-targeted Hg-specific fluorescent probe 1 based on ESIPT phthalimide was designed and synthesized for the first time. Owing to the blockage of the ESIPT process between the hydroxy group and the carbonyl oxygen of the imide by the diphenylphosphinothioate group, 1 was almost nonfluorescent. After reacting with Hg, 1 exhibited a dramatic fluorescence enhancement due to the recovery of the ESIPT process through Hg-induced desulfurization-hydrolysis of the diphenylphosphinothioate moiety and the cleavage of the P-O bond.

Identification of key DNA methylation changes on fasting plasma glucose: a genome-wide DNA methylation analysis in Chinese monozygotic twins.

Background: Elevated fasting plasma glucose (FPG) levels can increase morbidity and mortality even when it is below the diagnostic threshold of type 2 diabetes mellitus (T2DM). We conducted a genome-wide DNA methylation analysis to detect DNA methylation (DNAm) variants potentially related to FPG in Chinese monozygotic twins.

Methods: Genome-wide DNA methylation profiling in whole blood of twins was performed using Reduced Representation Bisulfite Sequencing (RRBS), yielding 551,447 raw CpGs.

Exploring the bidirectional associations between handgrip strength and depression in middle and older Americans.

Objective: Current evidence on the relationship between decreased handgrip strength and depression risk is controversial, and there is limited study focus on the potential bidirectional associations between them. We aim to explore their bidirectional relationships.

Methods: This study used panel data from the Health and Retirement Study involving 17,713 aging Americans (≥50 years old) who participated in at least 2 waves.

Insomnia symptoms are associated with an increased risk of type 2 diabetes mellitus among adults aged 50 and older.

Purpose: To evaluate the association of the different degrees of insomnia symptoms with subsequent incidence of type 2 diabetes mellitus (T2DM).

Methods: The data were extracted from Health and Retirement Study 2006-2014 waves. The association of insomnia symptoms with T2DM incidence was evaluated by the competing risk model with cumulative incidence function (death was considered a competing event) and Cox proportional hazard model with the Kaplan-Meier method.

The use of oral contraceptive is inversely associated with the risk of type 2 diabetes mellitus among middle-aged women.

Objective: To assess the cross-sectional association between oral contraceptive (OC) use and type 2 diabetes mellitus (T2DM) risk among US women.

Methods: The data was obtained from the National Health and Nutrition Examination Survey (NHANES 2007-2018). OC use was assessed by questionnaires and the diagnosis of T2DM was confirmed by the glycosylated hemoglobin, fasting blood glucose, and self-report.

Associations of Dietary ω-3, ω-6 Fatty Acids Consumption with Sleep Disorders and Sleep Duration among Adults.

The relationship between ω-3 and ω-6 fatty acids consumption and sleep disorders or duration are controversial. Therefore, we used the data of the National Health and Nutrition Examination Survey 2007-2016 in this cross-sectional study to explore their relationships. ω-3 and ω-6 fatty acids consumption was assessed using two 24 h dietary recall interviews.

An Eu(III)-functionalized Sr-based metal-organic framework for fluorometric determination of Cr(III) and Cr(VI) ions.

An Eu(III)-functionalized strontium-organic framework (Eu@Sr-MOF) was synthesized by encapsulating Eu ions into the pores of Sr-MOF via postsynthetic modification (PSM) and fully characterized by XRD, SEM, EDS, FTIR, and TGA. The luminescent properties of Eu@Sr-MOF were measured and investigated in detail, which demonstrated that Eu@Sr-MOF not only possessed excellent water and chemical stabilities in a wide pH range (5-10) but also displayed red luminescence with excitation/emission maxima at 332/617 nm. The Eu@Sr-MOF can be considered as a highly selective and sensitive recyclable luminescence probe for sensing Cr(III) and Cr(VI) based on strong luminescence quenching effects; it can be recycled at least five times.

Ultrastable Triazine-Based Covalent Organic Framework with an Interlayer Hydrogen Bonding for Supercapacitor Applications.

Covalent organic frameworks (COFs) with redox-active units are a class of ideal materials for electrochemical-energy-storage devices. A novel two-dimensional (2D) PDC-MA-COF with redox-active triazine units was prepared via aldehyde-amine condensation reaction by using 1,4-piperazinedicarboxaldehyde (PDC) and melamine (MA) as structural units, which possessed high specific surface area ( = 748.2 m g), narrow pore width (1.

Pharmacologic Effect of Miao Medicine Maxim. on Collagen-Induced Arthritis in Rats.

Objectives: To study the pharmacologic effect and mechanism of action of Miao medicine Maxim. (ISM) in treating rheumatoid arthritis.

Methods: Sixty rats were randomly divided to six groups: normal control (normal), collagen-induced arthritis (CIA) model (model), CIA + tripterygium glycosides (TG), CIA + ISM high dose oral (ISM-H), CIA + ISM low-dose oral (ISM-L), and CIA + ISM topical application (ISM-T).