Cbl-b inhibition improves manufacturing efficiency and antitumoral efficacy of anti-CD19 CAR-T cells.

Chimeric antigen receptor T (CAR-T) cells represent a promising approach for cancer immunotherapy, yet their efficacy is hindered by immunosuppressive signals in the tumor microenvironment. Casitas B-cell lymphoma protein b (Cbl-b) is a key negative regulator of T cell function. This study investigated whether inhibiting Cbl-b enhances the antitumor activity of human CAR-T cells.

Sulfate Oxyanion Steered d-Orbital Electronic State of Nickel-Iron Nanoalloy for Boosting Electrocatalytic Performance.

Oxyanion groups recently offer an innovative avenue for improving the sluggish kinetics of electrochemical reactions benefitting from their particular polyanion configurations and large electronegativity. Nevertheless, the exact structure design and deep regulating mechanism of oxyanion species remain poorly understood. Herein, a fresh architecture of the sulfate oxyanion coordinated nickel-iron nanoalloy on nitrogen and sulfur co-doped carbon nanotube (SO -NiFe/NSCT) is newly proposed to study the activity increment effect and mechanism.

A De Novo Auto-Activated Solar-Driven Biohybrid System for Hydrogen Production in Methanotrophic Cells.

Climate change driving by greenhouse gas emissions from petroleum-based energy has garnered significant attention. Renewable energy production via a sustainable system that integrates the cell factory and visible-light-driven photocatalysts offers a novel approach for upcycling methane and addressing global energy challenges. Here, an auto-activated biohybrid system driven by solar energy is developed for converting methane into hydrogen fuel, which incorporated thienoviologen (S-MV) and genetically engineered methanotrophic bacteria.

A novel ZnO-TiO-BiWO/Carboxymethyl chitosan composite with high antimicrobial activity and visible-light catalytic degradation of ethylene towards banana preservation in hot and humid environments.

In order to solve the problem of significantly shortened storage time of bananas in hot and humid environment (e.g., 30 °C and 90 % relative humidity), this paper reports the preparation of ZnO-TiO-BiWO (ZTB) ternary heterojunction antimicrobial photocatalysts composite carboxymethyl chitosan film (ZTB/CMCS).

Photocatalytic Hydrosilylation over Pt@UiO-66-NH: Enhanced Activity and Polymerization Kinetics.

Metal-organic frameworks (MOFs) have shown great research and application value in various types of hydrosilylation reactions. However, studies on photocatalysis-induced hydrosilylation using MOFs are extremely rare. Metal nanoparticles (MNPs)@MOFs are extensively studied for their excellent structural tunability and photocatalytic activity, but there are few reports on their application in photocatalytic hydrosilylation.

Effects of Curcumin on the Egg Quality and Hepatic Lipid Metabolism of Laying Hens.

Curcumin, the major active compound of turmeric, has shown potential benefits for poultry health and production in various studies. However, its specific role in enhancing the egg quality and liver health of laying hens, as well as its underlying mechanisms, have yet to be determined. Here, a total of 600 Su Qin No.

Understanding the selection of catalytic pathway on graphene-supported nitrogen coordinated Ru-atom by ab initio molecular dynamics simulation.

Context: In the paper, the ORR/OER on graphene-supported nitrogen coordinated Ru-atom (Ru-N-C) is simulated. We discuss nitrogen coordination influences electronic properties, adsorption energies, and catalytic activity in a single-atom Ru active site. The over potentials on Ru-N-C are 1.

ATP2B3 Inhibition Alleviates Erastin-Induced Ferroptosis in HT-22 Cells through the P62-KEAP1-NRF2-HO-1 Pathway.

Ferroptosis participates in the occurrence and development of neurological disorders. Modulating ferroptosis may have therapeutic potential in nervous system diseases. Therefore, TMTbased proteomic analysis in HT-22 cells was performed to identify erastin-induced differentially expressed proteins.

Chronic Corticosterone Exposure Suppresses Copper Transport through GR-Mediated Intestinal CTR1 Pathway in Mice.

Numerous studies have discovered that chronic stress induces metabolic disorders by affecting iron and zinc metabolism, but the relationship between chronic stress and copper metabolism remains unclear. Here, we explore the influence of chronic corticosterone (CORT) exposure on copper metabolism and its regulatory mechanism in mice. Mice were treated with 100 μg/mL CORT in drinking water for a 4-week trial.

One-step spray coating strategy toward a highly uniform large-area CsPbBr@PMMA composite film for backlit display.

The large-scale and continuous production of CsPbBr@PMMA composite film is realized by the in-situ ultrasonic spray coating method at room temperature. Through embedding CsPbBr nanocrystals into the hydrophobic polymer framework, the as-fabricated films (20 cm × 20 cm) exhibit uniform green emissions with a relatively high PLQYs of 76%, and could maintain 80% PL intensity after 3 months storage under ambient conditions. Assembling the green-emissive CsPbBr@PMMA film and the red-emissive KSF@PMMA film with blue LED chip, a high-performance LCD is obtained, reaching a higher saturation with 126% and 94% color gamut of NTSC and Rec.

Role and mechanism of miR-335-5p in the pathogenesis and treatment of polycystic ovary syndrome.

Polycystic ovary syndrome (PCOS) is a common endocrine disorder of unknown etiology that occurs in women of reproductive age. Despite being considered to affect up to one-fifth of women in this cohort, the condition lacks generally accepted diagnostic biomarkers and options for targeted therapy. Hereby, we analyzed the diagnostic, therapeutic, and functional potential of a recently discovered miR-335-5p that was observed to be reduced in the follicular fluid (FF) of PCOS patients as compared with healthy women.

Selenoviologen-Appendant Metallacycles with Highly Stable Radical Cations and Long-Lived Charge Separation States for Electrochromism and Photocatalysis.

Two coordinated metallacycles (rhomboid for M1, hexagonal for M2) with selenoviologens (SeV ) pendants were synthesized via coordination-driven hierarchical self-assembly. M1/M2 with rigid and discrete metallacyclic cores showed tunable optoelectronic properties due to strong π-π stacking and push-pull electron structures. Femtosecond transient absorption (fs-TA) revealed that the formation of macrocyclic structure can not only enhance the stability of radical cation, but also improve the efficiency of intramolecular charge transfer and produce a long-lived charge separation state.

Deletion of Letmd1 leads to the disruption of mitochondrial function in brown adipose tissue.

Human cervical cancer oncogene (HCCR-1), also named as LETMD1, is an LETM-domain containing outer mitochondrial membrane protein which plays an important role in carcinogenesis. The present study found that the loss of Letmd1 in mice led to severe abnormities, such as brown adipose tissue (BAT) whitening, impaired thermogenesis of both BAT and beige fat, cold intolerance, diet-induced obesity, glucose intolerance and insulin resistance. Mechanically, the deletion of Letmd1 in BAT caused decreased level of both mitochondrial and intracellular Ca.

Chronic Psychological Stress Disrupts Iron Metabolism and Enhances Hepatic Mitochondrial Function in Mice.

To explore the changes in iron metabolism and mitochondrial function exposed to chronic psychological stress, seventy-five male mice aged 5 ~ 6 weeks were randomly sorted into 2 groups: control group and chronic psychological stress group. Mice were conducted by communication box to induce psychological stress for 21 consecutive days. The results showed that chronic psychological stress led to a significant reduction in average daily gain (P < 0.

Accelerated discovery of thermostable high-energy materials with intramolecular donor-acceptor building blocks.

A domain-related data search promoted triazolotriazine-fused energetic scaffold filtration with combinatorial design to alleviate the lack of thermostable high-energy materials; 16 candidates were discovered that may show promising energy and safety performance, as well as excellent thermal stability. Novel fused triazolo-1,2,4-triazine energetic material 7-nitro-3-(1-tetrazol-5-yl)-[1,2,4]triazolo[5,1-][1,2,4]triazin-4-amine-2-oxide (Candidate No. 4) with excellent thermal stability, high energy performance and low sensitivity was developed successfully by using a facile N-oxide synthetic method.

-Terphenylene Viologens with Through-Space Conjugation for Enhanced Photocatalytic Oxidative Coupling and Hydrogen Evolution.

A series of novel terphenylene viologen derivatives (TPV) with through-space conjugation (TSC) via the combination of terphenylene skeletons with viologen structure is reported. Their optoelectronic properties can be adjusted by -arylation or -alkylation reactions. Compared with other viologen derivatives, TPV not only exhibits strong photoluminescence but also retards the charge recombination process and stabilizes the diradical state without forming a quinoid structure due to the special TSC effect.

Preparation of Butadiene-Bridged Polymethylsiloxane/Ethylcellulose/1-Carboxymethyl-3-methylimidazolium Chloride Ternary Composite Membranes for Gas Separation.

Excessive CO emissions have resulted in global warming and are a serious threat to the life of people, various strategies have been implemented to cut carbon emissions, and one of them is the use of a gas separation membrane to capture CO effectively. In this experiment, the butadiene-bridged polymethylsiloxane (BBPMS)/ethyl cellulose (EC)/ionic liquid (IL) ternary composite membranes were prepared by EC as a substrate, BBPMS, and IL as additives in tetrahydrofuran under high-speed stirring and coated on the membrane. The membrane structure was characterized by a Fourier transform infrared spectrometer and scanning electron microscope, and the membrane properties were tested by a membrane tensile strength tester, thermal weight loss analyzer, and gas permeability meter.

Optimization of a MOF Blended with Modified Polyimide Membrane for High-Performance Gas Separation.

The preparation, characterization and gas separation properties of mixed matrix membranes (MMMs) were obtained from polyimide capped with ionic liquid and blended with metal-organic frameworks (MOFs). The synthesized MOF was amine functionalized to produce UiO-66-NH, and its amino group has a higher affinity for CO. Mixed matrix membranes exhibited good membrane forming ability, heat resistance and mechanical properties.

Bacteria-Triggered Solar Hydrogen Production via Platinum(II)-Tethered Chalcogenoviologens.

Multifunctional solar energy conversion offers a feasible strategy to solve energy, environmental and water crises. Herein, a series of platinum(II)-tethered chalcogenoviologens (PtL -EV , E=S, Se, Te) is reported, which integrate the functions of photosensitizer, electron mediator and catalyst. PtL -EV (particularly for PtL -SeV )-based one-component solar H production could be triggered not only by EDTA, but also by facultative anaerobic and aerobic bacteria relying on a simplified mechanism, along with efficient antibacterial activities.

Macrophage deletion of Noc4l triggers endosomal TLR4/TRIF signal and leads to insulin resistance.

In obesity, macrophages drive a low-grade systemic inflammation (LSI) and insulin resistance (IR). The ribosome biosynthesis protein NOC4 (NOC4) mediates 40 S ribosomal subunits synthesis in yeast. Hereby, we reported an unexpected location and function of NOC4L, which was preferentially expressed in human and mouse macrophages.

α-Lipoic Acid Alleviates Hepatic Lipid Deposition by Inhibiting FASN Expression via miR-3548 in Rats.

Excessive liver lipid deposition is a vital risk factor for the development of many diseases. Here, we fed Sprague-Dawley rats with a control or α-lipoic acid-supplemented diet (0.2%) for 5 weeks to elucidate the effects of α-lipoic acid on preventive ability, hepatic lipid metabolism-related gene expression, and the involved regulatory mechanisms.

A Novel Imide-Bridged Polysiloxane Membrane Was Prepared via One-Pot Hydrosilylation Reaction for O/N Separation.

The synthesis of poly(methyhydrosiloxane) (PMHS) and ,'-bis(3-allyl)pyromellitic diimide was optimized for O/N separation. The membrane exhibits excellent mechanical and thermal properties and shows an O/N selectivity of up to 4.44 with an O permeability of 31.

Chronic Variable Stress Induces Hepatic Fe(II) Deposition by Up-Regulating ZIP14 Expression via miR-181 Family Pathway in Rats.

It is well-known that hepatic iron dysregulation, which is harmful to health, can be caused by stress. The aim of the study was to evaluate chronic variable stress (CVS) on liver damage, hepatic ferrous iron deposition and its molecular regulatory mechanism in rats. Sprague Dawley rats at seven weeks of age were randomly divided into two groups: a control group (Con) and a CVS group.

Preparation and High Performance of Cellulose Acetate Films by Grafting with Imidazole Ionic Liquid.

Cellulose acetate (CA) grafted with imidazole ionic liquids (CA-ILs) was synthesized by reacting CA with imidazole ionic liquids ([HOCMmim]Cl, [HOCEtmim]Cl, and [HOCMmim]Br) by using tetrahydrofuran (THF) as the solvent and pyridine as the catalyst. The CA and CA-IL films were fabricated by using the casting solution method. The CA-IL films exhibited good film forming ability and mechanical properties.