Integrated photonics has emerged as a pivotal technology in the advancement of next-generation computing and communication devices. Thermal optical phase shifters (OPSs) have been widely used to realize a tunable Mach-Zehnder interferometer (MZI) and a micro-ring resonator (MRR), which are the building bricks for the LSI/VLSI photonic integrated circuits. Due to the thermal crosstalk and the low modulation efficiency, thermal OPSs have large-scale size and high power consumption.
View Article and Find Full Text PDFBackground: Phenols have been demonstrated to enhance protein gelation but their stability is often compromised in heat-induced gels. This has prompted the development of cold-induced gels. The objective of this study was to enhance the gel properties of hazelnut isolate protein (HPI) through the incorporation of transglutaminase (TGase), glucono-δ-lactone (GDL), and chlorogenic acid (CA).
View Article and Find Full Text PDFUlcerative colitis (UC) is a long-term inflammatory bowel disease characterized by intense inflammation of the colorectal mucosa. Overproduction of reactive oxygen species exacerbates the progression of UC, which is linked to mitochondrial impairment and dysbiosis of the intestinal microbiota. CaGA nanozymes have demonstrated efficacy in the treatment of UC.
View Article and Find Full Text PDFAs one of the most common inflammatory bowel diseases (IBDs), ulcerative colitis (UC) has become a rising global health issue that affects people's quality of life. Conventional therapeutic drugs have low bioavailability and may cause serious side effects due to their lack of acidic resistance and lesion-targeting capabilities. The development of novel nanomedicines to overcome these problems is urgently needed.
View Article and Find Full Text PDFACS Appl Mater Interfaces
March 2025
With the advent of droplet-based triboelectric nanogenerators (D-TENGs), methods for converting raindrop kinetic energy to electrical energy have developed rapidly. However, current D-TENG designs suffer from slow solid-liquid interface separation speeds and susceptibility to liquid residues. These issues compromise the output performance of D-TENGs and limit their applications in high-power electrical appliances.
View Article and Find Full Text PDFBackground: Spinal cord injury (SCI) poses a substantial challenge in contemporary medicine, significantly impacting patients and society. Emerging research highlights a strong association between SCI and chronic pain, yet the molecular mechanisms remain poorly understood. To address this, we conducted bioinformatics and systems biology analyses to identify molecular biomarkers and pathways that link SCI to chronic pain.
View Article and Find Full Text PDFAiming at the problem that asphalt pavement materials in plateau areas are vulnerable to freeze-thaw damage, research was carried out on asphalt pavements of representative road sections, and the temperature within the pavement structure was monitored using buried sensors. Based on this, an indoor test method for high-frequency freeze-thaw was established, and UV, thermo-oxygen-aging and high-frequency freeze-thaw tests were combined. The effects of aging and maximum aggregate particle size on the resistance of asphalt mixtures to high-frequency freeze-thaw were investigated using the splitting strength ratio, mass-loss rate and void-ratio changes by employing the newly made RS-type modified asphalt in the laboratory.
View Article and Find Full Text PDFThe platinum-based compounds are widely used in treating various types of cancer through their heavy metal component platinum. However, the development of chemoresistance often limits their clinical effectiveness. In this study, we report the roles of heavy metal response and its associated Hippo pathway in regulating platinum-based chemotherapy.
View Article and Find Full Text PDFHolographic displays have the potential to reconstruct natural light field information, making them highly promising for applications in augmented reality (AR), head-up displays (HUD), and new types of transparent three-dimensional (3D) displays. However, current spatial light modulators (SLMs) are constrained by pixel size and resolution, limiting display size. Additionally, existing holographic displays have narrow viewing angles due to device diffraction limits, algorithms, and optical configurations.
View Article and Find Full Text PDFNanozymes with specific catalytic activity inhibit inflammation and promote wound healing efficiently and safely. In this work, multifunctional manganese-based nanozymes (MnGA) with antioxidant properties were successfully constructed via a simple coordination reaction in which manganese chloride was used as the manganese source and gallic acid (GA) was used as the ligand solution. MnGA possesses both catalase-like (CAT-like) and superoxide dismutase-like (SOD-like) activities and a reactive nitrogen species (RNS) scavenging capacity, which enables it to efficiently inhibit the inflammatory response.
View Article and Find Full Text PDFDysregulated expression of microtubule-associated protein tau (MAPT) has been reported in a variety of human cancers. However, whether and how Tau influences hepatocellular carcinogenesis remains elusive. This study was aimed to investigate the role and the underlying mechanism of Tau in the proliferation, invasion, migration and sorafenib sensitivity of hepatocellular carcinoma (HCC) cells.
View Article and Find Full Text PDFClostridium perfringens (C. perfringens) type C exhibits strong pathogenicity, often leading to swine dysentery, severely affecting the economic efficiency of the pig farming industry. Bacteriophages as bacterial viruses have many natural advantages and are potent candidates for controlling bacterial infections.
View Article and Find Full Text PDFThe Hippo pathway is commonly altered in cancer initiation and progression; however, exactly how this pathway becomes dysregulated to promote human cancer development remains unclear. Here we analyze the Hippo somatic mutations in the human cancer genome and functionally annotate their roles in targeting the Hippo pathway. We identify a total of 85 loss-of-function (LOF) missense mutations for Hippo pathway genes and elucidate their underlying mechanisms.
View Article and Find Full Text PDFDeveloping porous materials with ultrahigh surface areas for gas storage (for example, methane) is attractive but challenging. Here, we report two isostructural three-dimensional covalent organic frameworks (COFs) with a rare self-catenated -3,6-2 topology and a pore size of 1.1 nanometer.
View Article and Find Full Text PDFEnriched environment (EE), characterized by multi-sensory stimulation, represents a non-invasive alternative for alleviating epileptic seizures. However, the mechanism by which EE exerts its therapeutic impact remains incompletely understood. Here, it is elucidated that EE mitigates seizure susceptibility through the augmentation of adult neurogenesis within the entorhinal cortex (EC) circuit.
View Article and Find Full Text PDFWith the prevalence of sequentially-emerged sublineages including BA.1, BA.2 and BA.
View Article and Find Full Text PDFTransl Vis Sci Technol
October 2024
Skin is the largest organ in the human body, and it is also the most important natural barrier. However, some accidents can cause skin damage. Bacterial infections and inflammatory reactions can hinder wound healing.
View Article and Find Full Text PDFBackground: Morphological parameters of the lumbar spine are valuable in assessing lumbar spine diseases. However, manual measurement of lumbar morphological parameters is time-consuming. Deep learning has automatic quantitative and qualitative analysis capabilities.
View Article and Find Full Text PDFBackground: Lumbar spine disorders are one of the common causes of low back pain (LBP). Objective and reliable measurement of anatomical parameters of the lumbar spine is essential in the clinical diagnosis and evaluation of lumbar disorders. However, manual measurements are time-consuming and laborious, with poor consistency and repeatability.
View Article and Find Full Text PDFNanomaterials (Basel)
July 2024
Mechanoluminescent (ML) materials can exhibit visible-to-near-infrared mechanoluminescence when responding to the fracture or deformation of a solid under mechanical stimulation. Transforming mechanical energy into light demonstrates promising applications in terms of visual mechanical sensing. In this work, we synthesized the phosphor CaZnOS:Tb, Sm, which exhibited intense and tunable multicolor mechanoluminescence without pre-irradiation.
View Article and Find Full Text PDFBackground: Spinal tuberculosis (STB) is a local manifestation of systemic infection caused by Mycobacterium tuberculosis, accounting for a significant proportion of joint tuberculosis cases. This study aimed to explore the diagnostic value of MRI combined with mannose-binding lectin (MBL) for STB.
Methods: 124 patients suspected of having STB were collected and divided into STB and non-STB groups according to their pathological diagnosis.