Publications by authors named "Wenpu Ren"

Article Synopsis
  • * The researchers used a T2DM mouse model and found that Sal improved heart function and reduced inflammation, as well as the structural and electrical changes in the heart caused by diabetes, over a period of four weeks.
  • * Sal's protective effects were linked to the suppression of a specific signaling pathway (mTOR-STAT3-MCP-1) that is involved in inflammation, and it showed potential as a new treatment
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Atrial fibrillation (AF) is the most prevalent sustained tachyarrhythmia in patients with cardiovascular diseases. Recently, it has been discovered that oxidative stress is an important contributor to AF. Therefore, antioxidant therapies for AF have great potential for clinical applications.

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Article Synopsis
  • FNDC5 is identified as a potential anti-arrhythmic protein, whose role and mechanism in diabetes-related atrial fibrillation (AF) are explored in this study.
  • Significant reductions in FNDC5 levels were observed in both diabetic mice and atrial samples from AF patients, leading to adverse atrial remodeling and increased AF susceptibility.
  • FNDC5 overexpression showed protective effects by enhancing antioxidant capacity, improving mitochondrial function, and reducing inflammation via NLRP3 activation and AMPK signaling, suggesting new therapeutic targets for managing diabetes-associated AF.
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