-Palmitoylethanolamide Exerts Antidepressant-Like Effects in Rats: Involvement of PPAR Pathway in the Hippocampus.

-Palmitoylethanolamide (PEA), an endocannabinoid-like molecule, participates in controlling behaviors associated with mental disorders as an endogenous neuroprotective factor. On the basis of accumulating evidence and our previous data, we tested the hypothesis that the antidepressant-like effects of PEA observed during chronic unpredictable mild stress (CUMS) are mediated by possible targets in the peroxisome proliferator-activated receptor alpha (PPAR) pathway. In this study, rats were subjected to 35 days of CUMS and treated with drugs such as PEA (2.