Publications by authors named "Wenpan Fang"
Occupational and environmental Sb exposure has been associated with increased risk of respiratory diseases and lung cancer, but the toxicities and molecular mechanisms of Sb have been less investigated. In the present study, we first analyzed the Sb toxicity profile of lung adenocarcinoma A549 cells, and found that Sb dose-dependently decreased the cell viability and arrested cell cycle at G2/M but did not induce apoptosis. We next investigated the role of reactive oxygen species (ROS) involved in Sb-induced cytotoxicity.
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- - Previous research has linked the genetic variant pre-miR-27a rs895819 to cancer risk, but results vary across different types of cancer, prompting this updated meta-analysis involving 34 studies with over 15,000 cases.
- - The analysis found that the rs895819 variant is associated with a slight increase in overall cancer risk (OR = 1.15) and particularly higher risk for colorectal cancer and lung cancer, especially among Asian populations, but not in Caucasians.
- - Interestingly, the [G] allele of rs895819 appears to lower the risk of breast cancer, while no significant association was observed with gastric or esophageal cancers, indicating varying effects of this genetic variant across different cancer types.
Silica nanoparticles (SiO2 NPs) cause oxidative stress in respiratory system. Meanwhile, human cells launch adaptive responses to overcome SiO2 NP toxicity. However, besides a few examples, the regulation of SiO2 NP-responsive proteins and their functions in SiO2 NP response remain largely unknown.
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