Publications by authors named "Wenny Astuti Achwan"
Aim: To identify the prevalence of pre-S2 start codon mutations and to assess their association with liver disease progression.
Methods: The mutations were identified by direct sequencing from 73 asymptomatic carriers, 66 chronic hepatitis (CH), 66 liver cirrhosis (LC) and 63 hepatocellular carcinoma (HCC) patients. Statistical significances were determined using Fisher's exact test, χ² test, and t-test analyses whenever appropriate.
The molecular epidemiological study of hepatitis B virus (HBV) in Indonesia is still limited. This study was aimed to identify the prevalence of HBV pre-S deletion/insertion mutations, and to assess the association of pre-S deletion mutation with liver disease progression in Indonesia. Pre-S mutations were identified by direct sequencing.
View Article and Find Full Text PDFAim: To identify the prevalence of hepatitis B e antigen (HBeAg) and to assess the association of hepatitis B virus (HBV) core promoter mutations and viral load in Indonesian patients.
Methods: Sixty-four patients with chronic hepatitis, 65 with liver cirrhosis and 50 with hepatocellular carcinoma were included in this study. HBeAg and hepatitis B e antibody (HBeAb) tests were performed using enzyme-linked immunosorbent assay and the mutations were analyzed by sequencing.
Article Synopsis
- - The study focused on understanding the distribution of hepatitis B virus (HBV) subgenotypes and specific mutations in patients with liver diseases in Indonesia, including chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma.
- - Results indicated that HBV genotype B was the most common, found in about 75% of patients with all types of liver disease, while genotype C appeared in around 25%. Specific subgenotypes B3 and C1 were the most frequent among these.
- - The analysis revealed that certain mutations in the virus's basal core promoter (BCP) were significantly more prevalent in patients with liver cirrhosis and hepatocellular carcinoma compared to those with chronic hepatitis, suggesting these mutations
Background/aims: The epidemiology of hepatitis B, C,E viruses (HBV, HCV, HEV) and human immunodeficiency virus(HIV) has been obscure in Indonesia, particularly remote areas.
Methods: We undertook serological surveys for HBV/HCV/HEV/HIV infections in the general population of Tahuna, the capital city of Sangihe-Talaud Archipelago,outlier in the northeastern part of Indonesia.
Results: Of 581 sera collected in April 2005, 1.