Anti-Osteoporotic Effect of AR281 in an Ovariectomized Mouse Model Mediated by Inhibition of Osteoclast Differentiation.

Osteoporosis is a global disease characterized by weakened bone microarchitecture, leading to osteoporotic fractures. Estrogen replacement therapy is the traditional treatment for osteoporosis but carries with it an increased risk of cardiac events. In search of a safe and effective treatment, we used AR281, which has anti-inflammatory properties, to conduct a 7-week experiment, investigating its inhibitory effects on osteoporosis in an ovariectomized (ovx) mouse model.

Halovibrio salipaludis sp. nov., Isolated from Saline-Alkaline Soil.

A Gram-staining-negative, halophilic, aerobic, oval-shaped or vibrio-shaped, motile by a polar flagellum strain, designated YL5-2, was isolated from natural saline-alkaline wetland soil of Binhai new district, Tianjin, China. Strain YL5-2 grew optimally at 35 °C, pH 7.5-8.