Design, synthesis, antifungal, and antibacterial evaluation of ferulic acid derivatives bearing amide moiety.

Natural compounds' derivatives as lead structures could effectively solve plant disease problems. In this article, amide compounds and amide ester compounds were synthetized through ferulic acid as the parent nucleus structure, and their biological activities in vitro and in vivo were evaluated. Compound 1q was screened out as the one with the best activity performance toward Xanthomonas axonopodis pv.

Design, synthesis, molecular docking and antimicrobial evaluation of benzoylurea derivatives containing difluoromethyl (trifluoromethyl) pyrimidine.

Background: The reduction in agricultural product quality and yield caused by fungal and bacterial plant diseases has led to considerable economic losses in global crop production and poses a threat to human health. The primary method of control remains the use of chemical agents. In an effort to develop novel and highly effective antimicrobial agents, a series of benzoylurea derivatives incorporating a difluoromethyl (trifluoromethyl) pyrimidine structure were designed and synthesized.

Synthesis, biological evaluation, and molecular docking of novel ferulic acid derivatives containing a 1,3,4-oxadiazole thioether and trifluoromethyl pyrimidine skeleton.

In this study, 24 novel ferulic acid derivatives containing 1,3,4-oxadiazole thioether and trifluoromethyl pyrimidine were designed and synthesized. Bioactivity assay showed that some of the target compounds exhibited moderate to good antifungal activity against BD), sp. (PS), (BC), spp.

Rational design, synthesis, and antimicrobial evaluation of novel 1,2,4-trizaole-substituted 1,3,4-oxadiazole derivatives with a dual thioether moiety.

In this paper, a series of novel 1,2,4-trizaole-substituted 1,3,4-oxadiazole derivatives with a dual thioether moiety were constructed. The synthetic compounds were characterized by H NMR, C NMR, HRMS, and single crystal diffraction. The antimicrobial activities of title compounds against fungi (Pyricutaria oryzae Cav.

A flexible modulated pesticide release platform through poly(urethane-urea) microcapsules: effect of different crosslinkers compositions.

Background: Polymeric microcapsules (MCs) have become an important issue and have attracted increasing attention because of their tunable physical and chemical properties. Diverse shell structures can confer multiple properties on MCs.

Results: Different polyols (1,4-butanediol and glycerin) and polyamines (triethylenetetramine and isophorondiamine) were selected as crosslinkers to obtain emamectin benzoate (EB)-loaded poly(urethane-urea) MCs (PU-MCs) by interfacial polymerization.

Discovery of Novel Compounds for Combating Rising Severity of Plant Diseases Caused by Fungi and Viruses.

In recent years, the severity of plant diseases caused by plant pathogenic fungi and viruses has been on the rise. However, there is a limited availability of pesticide chemicals in the market for effectively controlling both fungal and viral infections. To solve this problem, a series of novel pyrimidine derivatives containing a 1,3,4-oxadiazole thioether fragment were synthesized.

MOF-based stimuli-responsive controlled release nanopesticide: mini review.

By releasing an adequate amount of active ingredients when triggered by environmental and biological factors, the nanopesticides that respond to stimuli can enhance the efficacy of pesticides and contribute to the betterment of both the environment and food safety. The versatile nature and highly porous structure of metal-organic frameworks (MOFs) have recently garnered significant interest as drug carriers for various applications. In recent years, there has been significant progress in the development of metal-organic frameworks as nanocarriers for pesticide applications.

Synthesis, Antifungal, and Antibacterial Activities of Novel Benzoylurea Derivatives Containing a Pyrimidine Moiety.

To explore more efficient and less toxic antibacterial and antifungal pesticides, we utilized 2,6-difluorobenzamide as a starting material and ultimately synthesized 23 novel benzoylurea derivatives containing a pyrimidine moiety. Their structures were characterized and confirmed by H NMR, C NMR, F NMR, and HRMS. The bioassay results demonstrated that some of the title compounds exhibited moderate to good in vitro antifungal activities against in cucumber, in tobacco, in blueberry, sp.

Melatonin Enhances the Postharvest Disease Resistance of Blueberries Fruit by Modulating the Jasmonic Acid Signaling Pathway and Phenylpropanoid Metabolites.

In this study, to investigate the physiological and molecular mechanisms of melatonin inhibiting the postharvest rot of blueberry fruits, blueberry fruits were dipped in 0.3 mmol L melatonin solution for 3 min and stored at 0°C for 80 days. The results indicated that melatonin did not significantly ( > 0.

Design, Synthesis, and Antifungal Activity of Novel 1,2,4-Triazolo[4,3-]trifluoromethylpyrimidine Derivatives Bearing the Thioether Moiety.

Crop disease caused by fungi seriously affected food security and economic development. Inspired by the utilization of fungicide containing 1,2,4-triazole and trifluoromethylpyrimidine, a novel series of 1,2,4-triazolo[4,3-]trifluoromethylpyrimidine derivatives bearing the thioether moiety were synthesized. Meanwhile, the antifungal activities of the title compounds were evaluated and most compounds exhibited obvious antifungal activities against cucumber , strawberry , tobacco , blueberry , , and Cav.

Design, Synthesis, and Bioactivities of Novel Trifluoromethyl Pyrimidine Derivatives Bearing an Amide Moiety.

Twenty-three novel trifluoromethyl pyrimidine derivatives containing an amide moiety were designed and synthesized through four-step reactions and evaluated for their antifungal, insecticidal, and anticancer properties. Bioassay results indicated that some of the title compounds exhibited good antifungal activities against (), sp., (), (), (), and () at 50 μg/ml.

Metal-Organic Framework (UiO-66)-Based Temperature-Responsive Pesticide Delivery System for Controlled Release and Enhanced Insecticidal Performance against .

is a global pest that brings about great disasters to crops. Conventional pesticide formulations often suffer from poor water solubility, low stability, burst release, weak leaf adhesion, and low efficiency. To improve the insecticidal activity of pesticides, a stimuli-responsive controlled release pesticide delivery system (PDS) has attracted extensive attention in recent years.

Laboratory Screening of Control Agents Against Isolated Fungal Pathogens Causing Postharvest Diseases of Pitaya in Guizhou, China.

Pitaya, or dragon fruit, is a typical tropical fruit with an appealing taste and diverse health benefits to humans. The plantation of pitaya in Guizhou province in China has greatly boosted the income of local farmers and alleviated poverty. However, the frequent occurrence of postharvest diseases has brought large economic loss.

Novel Pyrimidine Derivatives Bearing a 1,3,4-Thiadiazole Skeleton: Design, Synthesis, and Antifungal Activity.

In this study, twenty novel pyrimidine derivatives bearing a 1,3,4-thiadiazole skeleton were designed and synthesized. Then their antifungal activity against (), (), and sp. were determined using the poison plate technique.

Effects of Ozone Fumigation on the Main Postharvest Pathogenic Fungi sp. and the Storage Quality of Blueberry in Majiang County, China.

In this study, the fungus sp. was isolated from rotting postharvest blueberry fruits at different storage stages and identified into genera. Inoculation of this strain on the surface of fresh fruits was able to cause rotting.

Vulgarisin-type diterpenoids from self-heal () and their neuroprotective effects against ischemia/reperfusion (I/R) a mitochondria-related pathway.

Self-heal ( L.) is a perennial edible plant that is widely distributed across the world and is traditionally consumed as a food additive in soft drink beverages. In this study, to explore the functional components of , an investigation of its ethanol extracts has been conducted by our group.

Synthesis of novel antibacterial and antifungal quinoxaline derivatives.

A series of quinoxaline derivatives were designed, synthesized and evaluated as antimicrobial agents against plant pathogenic bacteria and fungi. Some of these compounds exhibited significant antibacterial and antifungal activities . Compound 5k displayed good antibacterial activity against ().

MXene (TiC) Based Pesticide Delivery System for Sustained Release and Enhanced Pest Control.

A multifunctional nanomaterials based pesticide delivery system provides a powerful strategy for the efficient utilization of pesticides. We present here the application of a 2D MXene (TiC) nanomaterial for pesticide delivery and plant protection. Avermectin (AV), a hydrophobic and unstable insecticide, was chosen as the model pesticide.

Verification of Acetylation of Trichodermol to Trichodermin in the Plant Endophyte .

Trichodermin, a trichothecene first isolated in species, is a sesquiterpenoid antibiotic that exhibits significant inhibitory activity to the growth of many pathogenic fungi such as , , and by inhibiting the peptidyl transferase involved in eukaryotic protein synthesis. Trichodermin has also been shown to selectively induce cell apoptosis in several cancer cell lines and thus can act as a potential lead compound for developing anticancer therapeutics. The biosynthetic pathway of trichodermin in has been identified, and most of the involved genes have been functionally characterized.

Synthesis and Antifungal Activity of Pyrimidine Derivatives Containing an Amide Moiety.

In this study, 17 novel pyrimidine derivatives containing an amide moiety were synthesized. Then their antifungal activities against (), sp., and () were determined.

PDA@Ti C T as a novel carrier for pesticide delivery and its application in plant protection: NIR-responsive controlled release and sustained antipest activity.

Background: Stimuli-responsive pesticide controlled release system provides a new strategy for the development of high-efficiency pesticides formulation.

Results: In this article, we report a novel polydopamine surface modified MXene-Ti C T nanocarrier for pesticide delivery and plant protection. Polydopamine modified Ti C T (PDA@Ti C T ) nanocarrier was prepared by biomimetic self-polymerization of dopamine on the surface of Ti C T .

Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of Glucosides.

A series of novel 1,3,4-thiadiazole derivatives of glucosides were synthesized by the starting materials -glucose and 5-amino-1,3,4-thiadiazole-2-thiol in good yields with employing a convergent synthetic route. The results of bioactivities showed that some of the target compounds exhibited good antifungal activities. Especially, compounds showed higher bioactivities against (), with the EC values of 3.

Synthesis and Bioactivities Study of Novel Pyridylpyrazol Amide Derivatives Containing Pyrimidine Motifs.

In this study, thirteen new pyridylpyrazolamide derivatives containing pyrimidine motifs were synthesized via six-step reactions. Bioassay results showed that some of the synthesized compounds revealed good antifungal properties against , and sp. at 50 μg/mL, which were similar to those of Kresoxim-methyl or Pyrimethanil.

Influences of different drying methods on the structural characteristics and prebiotic activity of polysaccharides from bamboo shoot (Chimonobambusa quadrangularis) residues.

In the present study, in order to assess the influences of drying methods on the chemical structures, in vitro digestibility and prebiotic potential of polysaccharides extracted from Chimonobambusa quadrangularis shoot (CPSs), four drying methods, including hot air-, vacuum-, freeze-, and spray-drying, were utilized to dry CPSs. Results revealed that the physicochemical characteristics and prebiotic activity of CPSs varied by different drying methods. In comparison with the other drying methods, freeze-dried CPSs had higher uronic acid content (9.

Synthesis and antiviral activity of 2-substituted methylthio-5-(4-amino-2-methylpyrimidin-5-yl)-1,3,4-oxadiazole derivatives.

A series of novel 2-substituted methylthio-5-(4-amino-2-methylpyrimidin-5-yl-)-1,3,4-oxadiazole derivatives were synthesized and evaluated for antiviral activities against tobacco mosaic virus (TMV) via half-leaf method. The preliminary biological results showed that these compounds exhibited good antiviral activity against TMV in vivo. Among these compounds, compounds 8f, 8h, 8k, 8n, 8q and 8w exhibited the similar curative effect against TMV (EC50=290.