Publications by authors named "Wenlu Shan"
Article Synopsis
- Recent research has shifted focus to the roles of cyclin-dependent kinases 7 and 9 (CDK7 and CDK9) beyond the cell cycle, highlighting their involvement in cell stress response, metabolism of harmful substances, and maintaining internal stability.
- Under stress conditions, the expression of AccCDK7 and AccCDK9 is significantly increased, which is vital for bees’ survival during high temperature challenges.
- Silencing these kinases affects antioxidant gene expression and enzyme activity, while overexpressing them in yeast enhances stress resistance, suggesting a critical role for AccCDK7 and AccCDK9 in honeybee oxidative stress responses.
4-Hydroxyphenylpyruvate dioxygenase (HPPD), a nonheme oxygenase, catalyzes the second step of the tyrosine catabolic pathway, which is shared by almost all aerobic life forms. This demonstrates its importance in aerobic biology. We isolated an HPPD homolog from Apis cerana cerana and named it AccHPPD.
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- The study focuses on the cyclin-dependent kinase (CDK) protein family, specifically the cloning and functional analysis of AccCDK1 from the honey bee species A. cerana cerana, highlighting its role in cell cycle regulation and metabolism.
- Researchers discovered that AccCDK1 is distributed in a tissue-specific manner and its expression is influenced by various stress factors like chemical exposure and extreme temperatures, indicating its potential role in enhancing honey bee resistance to stress.
- The silencing of AccCDK1 led to decreased antioxidant gene expression and reduced activity of key antioxidant enzymes, suggesting that AccCDK1 is crucial for oxidative stress resistance and normal cellular functions in honey bees.
Article Synopsis
- The GhMKK6-GhMPK4 MAPK signaling pathway is crucial for cotton's immunity against stresses, particularly wilt.
- Silencing the GhMPK4 gene leads to reduced resistance to wilt and lowers expression of key resistance-related genes.
- The study identified GhAP2C1 as a negative regulator in this pathway, showing that modifying its expression affects cotton's wilt resistance, clarifying the MAPK cascade's regulatory mechanisms against pathogens.
Article Synopsis
- Glutathione S-transferases (GSTs) are key enzymes that help protect cells from oxidative stress and aid in detoxification.
- In this study, a GST-like gene (AccGSTL) was isolated from the honeybee species Apis cerana cerana and was shown to respond to oxidative stress by altering its mRNA and protein levels.
- When overexpressed in E. coli, AccGSTL increased resistance to oxidative stress, while silencing it reduced the expression of antioxidant genes and decreased key enzyme activities, indicating its role in defense against stress.