A mitochondrion-targeted poly(N-isopropylacrylamide-coacrylic acid) nanohydrogel with a fluorescent bioprobe for ferrous ion imaging in vitro and in vivo.

An imbalance in iron homeostasis contributes to mitochondrial dysfunction, which is closely linked to the pathogenesis of various diseases. Herein, we developed a nanosensor for detecting mitochondrial ferrous ions in vitro and in vivo. A poly(N-isopropylacrylamine)-coacrylic acid nanohydrogel was synthesized, and ferrous ions were detected using the fluorescent probe FeRhonox-1 embedded within it.

CGRP promotes osteogenic differentiation by regulating macrophage M2 polarization through HDAC6/AKAP12 signaling pathway.

To determine the mechanism of Calcitonin gene-related peptide (CGRP) in bone healing. Alkaline phosphatase (ALP) activity and inflammatory-factor levels were detected using ELISA. Osteogenic differentiation was assessed using Alizarin red staining technique.

Effects of Cr Addition on the Microstructure and Mechanical Properties of an Al-Si-Cu-Mg Alloy.

The effects of chromium (Cr) addition ranging 0.1-0.3 wt.

Gallium-Containing Materials and Their Potential within New-Generation Titanium Alloys for Biomedical Applications.

With the rising demand for implantable orthopaedic medical devices and the dominance of device-associated infections, extensive research into the development of novel materials has been prompted. Among these, new-generation titanium alloys with biocompatible elements and improved stiffness levels have received much attention. Furthermore, the development of titanium-based materials that can impart antibacterial function has demonstrated promising results, where gallium has exhibited superior antimicrobial action.

Puerarin facilitates osteogenesis in steroid-induced necrosis of rabbit femoral head and osteogenesis of steroid-induced osteocytes via miR-34a upregulation.

The present study investigated the effect of puerarin on promoting the osteogenesis in steroid-induced necrosis of the femoral head (SONFH). New Zealand rabbits were administrated with horse serum and methylprednisolone (MPS) for establishing SONFH in vivo model, which was then treated with puerarin treatment. Histo-morphological changes in the femoral head were examined by hematoxylin-eosin staining.

Acute and 30-day oral toxicity studies of a novel coccidiostat - ethanamizuril.

Ethanamizuril is a novel triazine compound that exhibits remarkable anticoccidial activity. Owing to its pharmacological properties, this study was conducted to evaluate the acute and 30-day oral toxicity of ethanamizuril. In the acute study, ethanamizuril was administered once by oral gavage to mice and rats.

Effect of niobium content on the microstructure and Young's modulus of Ti-xNb-7Zr alloys for medical implants.

New generation titanium alloys with low elastic moduli are promising materials for medical implants, particularly load-bearing orthopaedic implants. In this paper, the effect of niobium content on the microstructure and mechanical properties of new Ti alloys including Ti-23Nb-7Zr, Ti-28Nb-7Zr and Ti-33Nb-7Zr (wt%) is studied. Ti-23Nb-7Zr was found to mainly form α΄ and α″- phases, while both the Ti-28Nb-7Zr and Ti-33Nb-7Zr consisted of α″ and β-phases with an increased amount of β-phase in the alloy with 33 wt% of Nb.

Pinoresinol promotes MC3T3‑E1 cell proliferation and differentiation via the cyclic AMP/protein kinase A signaling pathway.

Estradiol (E2) is a first‑line drug for osteoporosis (OP) treatment via promotion of osteoblastic proliferation and differentiation. However, a long‑term use of E2 would produce side effects thus, it is imperative to discover safer and more effective drugs. Pinoresinol (PINO) has a similar chemical structure to E2.

The Dependence of Isothermal ω Precipitation on the Quenching Rate in a Metastable β-Ti Alloy.

The precipitation behavior of the α strengthening phase in metastable β-Ti alloys is highly dependent on heat treatment parameters such as quenching rate, heating rate and ageing temperature. In this paper we have investigated the influence of quenching rate on the formation of isothermal ω precipitates that have been regarded as potent nucleant sites for α precipitation. The results show that the β-solutionized alloy contains a β matrix with a layer structured morphology.

Acute and subchronic toxicity of arprinocid in Sprague-Dawley rats.

We subjected Sprague-Dawley rats to an acute and 13-week subchronic oral toxicity of arprinocid, a nucleoside analogue used as a coccidiostat, according to toxicological guidelines as part of its safety assessment. In the acute study, arprinocid was administered once by oral gavage to rats at doses ranging from 292.4 to 506.

Preparation, mechanical and degradation properties of Mg-Y-based microwire.

Mg-Y-based microwire which offers high strength in combination of low degradation rate has been prepared for the first time by a modified melt extraction technique. A circular Mg-Y-based microwire is achieved with an extraction rate of 40m/s, which is composed of Mg matrix and an amorphous phase, and exhibits higher basal texture than that of as-cast sample. The outstanding tensile strength accompanying with an acceptable elongation is obtained with an extraction rate of 40m/s.