Publications by authors named "Wenlong Li"

An abundant amount of colon cancers is diagnosed every year, accounting for 9% of malignant tumors. Even with the progress of relevant research, the 5-year survival rate for colon cancer is still less than 60%, indicating that improving the prognosis of colon cancer is still a challenge that needs to be overcome. This study employed the algorithm "scissor" to integrate the single-cell sequencing data and bulk transcriptome data with prognosis information to predict prognosis-associated cells (PAC).

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Here, we show that vitamin E succinate (VES) acts as a degrader for the mA RNA demethylase fat mass and obesity-associated protein (FTO), thus suppressing tumor growth and resistance to immunotherapy. FTO is ubiquitinated by its E3 ligase DTX2, followed by UFD1 recruitment and subsequent degradation in the proteasome. VES binds to FTO and DTX2, leading to enhanced FTO-DTX2 interaction, FTO ubiquitination, and degradation in FTO-dependent tumor cells.

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Ultrasound (US) based radiomics is susceptible to variations in scanners, sonographers. To retrospectively investigate the feasibility of an adapted cycle generative adversarial networks (CycleGAN) in the style transfer to improve US based radiomics in the prediction of lymph node metastasis (LNM) with images from multiple scanners for patients with early cervical cancer (ECC). The CycleGAN was firstly trained to transfer paired US phantom images from one US device to another one; the model was then further trained and tested with clinical US images of ECC by transferring images from four US devices to one specific device; finally, the adapted model was tested with its effects on the radiomics feature harmonization and accuracy of LNM prediction in US based radiomics for ECC patients.

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Article Synopsis
  • - The review evaluates how network analysis methods apply to traditional Chinese medicine (TCM), including its medicinal substances, compatibility theories, and syndromes.
  • - Researchers collected literature from various databases and categorized studies based on their research methods, focusing on constructing biological networks and analyzing their characteristics.
  • - The findings suggest that network analysis techniques can significantly enhance understanding of TCM's complex systems, facilitating its modernization and internationalization while supporting personalized treatment and scientific research.
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Quality detection is critical in the development of prepared dishes, with distributional uniformity playing a significant role. This study used hyperspectral imaging (HSI) and Moran's I to quantify distributional uniformity, employing pizza as case. Pizza ingredients' spectra were collected, pre-processed with Detrended Fluctuation Analysis (DFA), Savitzky-Golay (SG) and Standard Normal Variate (SNV), and down-scaled with Principal Component Analysis (PCA).

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Difference frequency generation (DFG) based tunable single-frequency mid-infrared (MIR) light sources are desirable for high-resolution spectroscopy, sensing, and imaging. In this work, we demonstrate a continuous-wave (CW) single-frequency DFG in a ZnGeP (ZGP) crystal driven by all-fiber near-infrared (NIR) fiber lasers, for the first time to our knowledge. The all-fiber NIR laser sources consist of a 1.

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Andrographolide (AG) is a diterpene lactone with significant anti-inflammatory and antitumor activities. However, the poor water solubility limits its clinical application. An andrographolide-salicylic acid (AG-SLA) nano-cocrystal delivery system was rapidly developed using hummer acoustic resonance (HAR) technology in this research.

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The objective of this paper is to rapidly and accurately quantify the content of the dominant crystal form of Sinomenine hydrochloride (SH) and to evaluate the respective characteristics of Raman spectroscopy and Fourier transform near infrared spectroscopy techniques for rapid quantification of crystalline substances. In this study, we performed an adulterated gradient quantification based on two new crystalline forms of SH prepared in the laboratory in combination with commercially available products. And established 86 samples containing 66 batches of ternary and 20 batches of binary mixtures.

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Complex tidal processes and suspended particulate matter (SPM) behavior influence the land-sea transport of terrestrial contaminants in estuaries. Contaminants are generally trapped within the estuarine maximum turbidity zone (MTZ), where SPM concentrations peak, misleading flux estimation. Here, we conducted high-resolution continuous sampling over two tidal cycles within the MTZ of a semidiurnal estuary.

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Introduction: Hypericum perforatum L. (HPL) is extensively researched domestically and internationally as a medicinal plant. However, no reports of studies related to the anticoagulant activity of HPL have been retrieved.

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Background: Automatic primary gross tumor volume (GTVp) segmentation for nasopharyngeal carcinoma (NPC) is a quite challenging task because of the existence of similar visual characteristics between tumors and their surroundings, especially on computed tomography (CT) images with severe low contrast resolution. Therefore, most recently proposed methods based on radiomics or deep learning (DL) is difficult to achieve good results on CT datasets.

Purpose: A peritumoral radiomics-guided generative adversarial network (PRG-GAN) was proposed to address this challenge.

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Volatile organic compounds (VOCs) are major chemical pollutants in indoor air. Indoor fabrics, such as curtains, carpets, sofas, and clothes, strongly adsorb VOCs due to their high loading rates and large specific surface areas. The desorption of VOCs from these fabrics can act as a secondary source, worsening indoor air pollution and prolonging its effects.

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Introduction: The inherent complexity of traditional Chinese medicine (TCM) poses significant challenges in directly correlating quality evaluation with clinical efficacy. Banxia-Houpo Decoction (BHD), a classical TCM formula, has demonstrated efficacy in treating globus hystericus. However, the intricate composition of BHD, which contains both volatile and non-volatile active components, complicates efforts to ensure its consistent quality and clinical effectiveness.

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Article Synopsis
  • - Carboxylesterase 2 (CES2) is primarily found in the liver and intestine, playing a significant role in metabolizing various compounds, influencing drug effectiveness, and affecting lipid and glucose metabolism.
  • - The study involved creating knockout mice lacking CES2 genes and transgenic mice with human CES2 to assess the effects of CES2 on drug metabolism and metabolic health.
  • - Findings revealed that while the absence of CES2 led to fatty liver and metabolic issues, introducing human CES2, especially in the intestine, improved these conditions and could potentially address metabolic syndrome challenges.
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The hazards of polycyclic aromatic hydrocarbons (PAHs) on occupationally exposed population have been widely acknowledged. However, the occupational exposure risks associated their derivatives, methylated PAHs, remain poorly understood. This study conducted a screen of 126 PAHs and 6 oxidative stress biomarkers (OSBs) in paired serum-urine samples from 110 petrochemical workers to assess the risk associated with different PAHs exposure.

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Silicon carbide (SiC) is renowned for its exceptional hardness, thermal conductivity, chemical stability, and wear resistance. However, the existing process is difficult to meet the high standards of uniform corrosion in its polishing process and surface roughness and flatness after polishing, new polishing fluids and technique optimization are crucial for development. The study optimized and validated the composition of the polishing fluid used in ultrasonic-assisted chemical-mechanical polishing (UACMP).

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With the rapid development of nuclear energy, the contamination of environmental water systems by uranium has become a significant threat to human health. To efficiently remove uranium from these systems, three types of silica-based polyamine resins-SiPMA-DETA (SiPMA: silica/poly methyl acrylate; DETA: diethylenetriamine), SiPMA-TETA (TETA: triethylenetetramine), and SiPMA-TEPA (TEPA: tetraethylenepentamine)-were successfully prepared, characterized, and evaluated in batch experiments. Characterization results showed that the silica-based polyamine resins were successfully prepared, and they exhibited a uniform shape and high specific surface area.

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This study uses a simple solvent casting technique to offer an innovative, cost-effective synthesis of a cellulose-lactone hybrid material for Rhodamine 6G dye adsorption. The modified cellulose revealed superior adsorption competencies, triumphing a maximum dye removal efficiency of 97.8 % under neutral pH.

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  • There is an urgent need for effective treatments for liver fibrosis, which require targeted delivery of antifibrotic drugs to activated hepatic stellate cells (aHSCs) due to challenges posed by collagen buildup.
  • The study created nanoparticle formulations (SF-siHSP47@VFPL NPs) that co-deliver the antifibrotic drug sorafenib and siRNA, leveraging vitamin A to enhance delivery efficiency to aHSCs by targeting their receptors.
  • In mouse models, these nanoparticles not only reduced liver fibrosis markers and promoted healing but also demonstrated strong antifibrotic effects by inducing cell death mechanisms, showcasing their potential for innovative treatment strategies in liver fibrosis.
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  • The study focused on creating a robust delivery system for tetrandrine (Tet) using acoustic resonance (AR) and freeze-drying technology to enhance its solubility and stability.
  • Researchers screened 54 stabilizers and utilized statistical designs (Plackett-Burman and Box-Behnken) to identify and optimize key factors affecting the quality of the nanosuspension (Tet-NS).
  • The resulting Tet-NS showed significantly improved solubility compared to pure Tet, maintained stability during storage, and has potential applications for other poorly water-soluble drugs.
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This study aimed to investigate the dynamic changes in the physicochemical properties of polysaccharides from nine common Polygonatum spp. during in vitro simulated saliva-gastrointestinal digestion, in vitro fermentation, and their subsequent effects on human gut microbiota. Results revealed that the total sugar contents of Polygonatum spp.

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  • Sinomenine hydrochloride (SH) has limited use in treating rheumatoid arthritis due to gastrointestinal side effects, particularly in the elderly who experience varying gastric emptying times.* -
  • To improve drug efficacy and minimize side effects, new sustained-release pellets were developed, combining regular and enteric-coated formulations optimized through careful design.* -
  • The study achieved high efficiency in drug encapsulation and stable release profiles, showing potential for better SH formulations and providing valuable insights for future research.*
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Background: Research underscores the significant influence of histone lactylation pathways in the progression of Alzheimer's disease (AD), though the molecular mechanisms associated with histone lactylation-related genes (HLRGs) in AD are still insufficiently investigated.

Methods: This study employed datasets GSE85426 and GSE97760 to identify candidate genes by intersecting weighted gene co-expression network analysis (WGCNA) module genes with AD-control differentially expressed genes (DEGs). Subsequently, machine learning refined key genes, validated by receiver operating characteristic (ROC) curve performance.

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Our knowledge of the origins, heterogeneity, and functions of cancer-associated fibroblasts (CAF) in pancreatic ductal adenocarcinoma (PDAC) has exponentially increased over the last two decades. This has been facilitated by the implementation of new models and single-cell technologies. However, a few key studies preceded the current exciting times in CAF research and were fundamental in initiating the investigation of CAFs and of their roles in PDAC.

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