Publications by authors named "Wenli X Tao"
Effects of mu opioid receptor antagonism on cognition in obese binge-eating individuals.
Psychopharmacology (Berl)
December 2012
Rationale: Translational research implicates the mu opioid neurochemical system in hedonic processing, but its role in dissociable high-level cognitive functions is not well understood. Binge-eating represents a useful model of 'behavioural addiction' for exploring this issue.
Objective: The aim of this study was to objectively assess the cognitive effects of a mu opioid receptor antagonist in obese individuals with binge-eating symptoms.
Article Synopsis
- * Administering clinically relevant doses (2, 5, and 10 mg) for 10 days showed that the drug was well tolerated with no significant health risks, and it did not noticeably alter vital signs or blood tests.
- * While GSK1521498 demonstrated some cognitive and pain tolerance effects—especially at higher doses—results were positive overall, suggesting it has a good safety profile and supports further clinical testing.
Endogenous opioids and µ-opioid receptors have been linked to hedonic and rewarding aspects of palatable food intake. The authors examined the safety, pharmacokinetic, and pharmacodynamic profile of GSK1521498, a µ-opioid receptor inverse agonist that is being investigated primarily for the treatment of overeating behavior in obesity. In healthy participants, GSK1521498 oral solution and capsule formulations were well tolerated up to a dose of 100 mg.
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